Detection of viable cortical neurons using benzodiazepine receptor imaging after reversible focal ischaemia in rats: comparison with regional cerebral blood flow

2000 ◽  
Vol 27 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Yoshiyuki Watanabe ◽  
Takayuki Nakano ◽  
Kenji Yutani ◽  
Hiroshi Nishimura ◽  
Hideo Kusuoka ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cortical Neurons ◽  
Regional Cerebral Blood Flow ◽  
Benzodiazepine Receptor ◽  
Receptor Imaging ◽  
Regional Cerebral Blood ◽  
Focal Ischaemia

Spontaneous waves of cerebral blood flow associated with a pattern of electrocortical activity

1994 ◽  
Vol 266 (1) ◽  
pp. R204-R214 ◽  
Author(s):  
E. V. Golanov ◽  
S. Yamamoto ◽  
D. J. Reis
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cortical Neurons ◽  
Regional Cerebral Blood Flow ◽  
High Amplitude ◽  
Regional Cerebral Blood ◽  
Doppler Flowmetry ◽  
Highly Correlated ◽  
Oxide Synthase ◽  
The Relationship

We examined the relationship between spontaneous changes in regional cerebral blood flow and electrocortical (ECoG) activity in spinalized rats anesthetized with 1.5% isoflurane. Regional cerebral blood flow, measured by laser-Doppler flowmetry, and ECoG activity were measured bilaterally in frontal and parietal cortex. Spontaneous cerebrovascular waves (SCWs) were seen in all (n = 80) rats and consisted of sawtoothed waves with an average amplitude of 20.1 +/- 0.78%, a duration of 11.7 +/- 0.6 s, and a frequency of 6.3 +/- 0.2 min-1. SCWs were always preceded by a high-amplitude burst of ECoG activity (averaging 752.0 +/- 41.8 microV at 5.6 +/- 0.2 Hz) and comparable to the well-recognized burst-suppression/barbiturate-spindle patterns of ECoG activity. The latency between bursts and SCWs averaged 1.71 +/- 0.05 s. The frequency of bursts and SCWs was highly correlated within and between cortical areas bilaterally (r > 0.9) and appeared synchronously across brain. Deepening anesthesia (to 1.75% isoflurane) reduced the frequency of bursts and SCWs by > 30% but not their correlation (r > 0.9) and minimally increased burst-SCW latency. SCWs differed from an uncommon sinusoidal oscillation regional cerebral blood flow triggered by changes in arterial pressure and independent of the ECoG. Bursts and SCWs were not affected by inhibition of nitric oxide synthase. The results indicate that a population of local cortical neurons, probably driven from subcortical pacemakers, when excited, elicits local cerebrovascular vasodilation.

Regional cerebral blood flow in schizophrenia while performing an attention task

2014 ◽  
Author(s):  
Scott Harcourt ◽  
Daniel G. Amen ◽  
Kristin C. Willeumier ◽  
Charles J. Golden
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Attention Task

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

133Xe-DSPECT: Normalwerte von zerebraler Ruhedurchblutung und Reservekapazität

1987 ◽  
Vol 26 (05) ◽  
pp. 192-197 ◽  
Author(s):  
T. Kreisig ◽  
P. Schmiedek ◽  
G. Leinsinger ◽  
K. Einhäupl ◽  
E. Moser
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebrovascular Disease ◽  
Correlation Coefficient ◽  
Regional Cerebral Blood Flow ◽  
Regression Line ◽  
Reserve Capacity ◽  
Regional Cerebral Blood ◽  
Quantitative Measurements ◽  
Before And After

Using the 133Xe-DSPECT technique, quantitative measurements of regional cerebral blood flow (rCBF) were performed before and after provocation with acetazolamide (Diamox) i. v. in 32 patients without evidence of brain disease (normals). In 6 cases, additional studies were carried out to establish the time of maximal rCBF increase which was found to be approximately 15 min p. i. 1 g of Diamox increases the rCBF from 58 ±8 at rest to 73±5 ml/100 g/min. A Diamox dose of 2 g (9 cases) causes no further rCBF increase. After plotting the rCBF before provocation (rCBFR) and the Diamox-induced rCBF increase (reserve capacity, Δ rCBF) the regression line was Δ rCBF = −0,6 x rCBFR +50 (correlation coefficient: r = −0,77). In normals with relatively low rCBF values at rest, Diamox increases the reserve capacity much more than in normals with high rCBF values before provocation. It can be expected that this concept of measuring rCBF at rest and the reserve capacity will increase the sensitivity of distinguishing patients with reversible cerebrovascular disease (even bilateral) from normals.

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