Radiolabelled somatostatin analogue treatment in gastroenteropancreatic neuroendocrine tumours: factors associated with response and suggestions for therapeutic sequence

2013 ◽  
Vol 40 (8) ◽  
pp. 1197-1205 ◽  
Author(s):  
Davide Campana ◽  
Gabriele Capurso ◽  
Stefano Partelli ◽  
Francesca Nori ◽  
Francesco Panzuto ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Somatostatin Analogue ◽  
Factors Associated ◽  
Therapeutic Sequence ◽  
Gastroenteropancreatic Neuroendocrine Tumours

scholarly journals Somatostatin analogues in acromegaly and gastroenteropancreatic neuroendocrine tumours: past, present and future

2016 ◽  
Vol 23 (12) ◽  
pp. R551-R566 ◽  
Author(s):  
Kjell Öberg ◽  
Steven W J Lamberts
Keyword(s):  
Medical Therapy ◽  
Neuroendocrine Tumours ◽  
Clinical Success ◽  
Serum Insulin ◽  
Therapeutic Option ◽  
Hormone Secretion ◽  
Somatostatin Analogues ◽  
Somatostatin Analogue ◽  
Prolonged Release ◽  
Gastroenteropancreatic Neuroendocrine Tumours

Acromegaly is a hormonal disorder that arises when the pituitary gland secretes excess growth hormone (GH), which in turn stimulates a concomitant increase in serum insulin-like growth factor 1 (IGF-1) levels. Gastroenteropancreatic neuroendocrine tumours (GEP-NET) constitute a heterogeneous group of tumours that can secrete serotonin and a variety of peptide hormones that may cause characteristic symptoms known as carcinoid syndrome or other symptoms and hormonal hypersecretion syndromes depending on the tumour’s site of origin. Current medical therapy for the treatment of acromegaly and GEP-NET involves the administration of somatostatin analogues that effectively suppress excess hormone secretion. After its discovery in 1979, octreotide became the first synthetic biologically stable somatostatin analogue with a short-acting formulation of octreotide introduced into clinical practice in the late 1980s. Lanreotide, another somatostatin analogue, became available in the mid-1990s initially as a prolonged-release formulation administered every 10 or 14 days. Long-acting release formulations of both octreotide (Sandostatin LAR and Novartis) and lanreotide (Somatuline Autogel, Ipsen), based on microparticle and nanoparticle drug-delivery technologies, respectively, were later developed, which allowed for once-monthly administration and improved convenience. First-generation somatostatin analogues remain one of the cornerstones of medical therapy in the management of pituitary and GEP-NET hormone hypersecretion, with octreotide having the longest established efficacy and safety profile of the somatostatin analogue class. More recently, pasireotide (Signifor), a next-generation multireceptor-targeted somatostatin analogue, has emerged as an alternative therapeutic option for the treatment of acromegaly. This review summarizes the development and clinical success of somatostatin analogues.

Accuracy of visual assessments of proliferation indices in gastroenteropancreatic neuroendocrine tumours

2013 ◽  
Vol 66 (8) ◽  
pp. 700-704 ◽  
Author(s):  
Helen T M Young ◽  
Norman J Carr ◽  
Bryan Green ◽  
Charles Tilley ◽  
Vidhi Bhargava ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Proliferation Indices ◽  
Gastroenteropancreatic Neuroendocrine Tumours ◽  
Visual Assessments

The prevalence and relevance of adrenal masses in patients with sporadic gastroenteropancreatic neuroendocrine tumours (GEP-NET)

2013 ◽  
Vol 78 (6) ◽  
pp. 950-956 ◽  
Author(s):  
George Kanakis ◽  
Kimberly Kamp ◽  
Konstantinos Tsiveriotis ◽  
Richard A. Feelders ◽  
Alexandra Zormpala ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Adrenal Masses ◽  
Gastroenteropancreatic Neuroendocrine Tumours
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