A genetically engineered strain of Saccharopolyspora erythraea that produces 6,12-dideoxyerythromycin A as the major fermentation product

1998 ◽  
Vol 49 (6) ◽  
pp. 725-731 ◽  
Author(s):  
D. Stassi ◽  
D. Post ◽  
M. Satter ◽  
M. Jackson ◽  
G. Maine
Keyword(s):  
Genetically Engineered ◽  
Saccharopolyspora Erythraea ◽  
Fermentation Product ◽  
Engineered Strain

A new β-class milbemycin derivative from a mutant of genetically engineered strain Streptomyces avermitilis AVE-H39

2021 ◽  
pp. 1-5
Author(s):  
Huan Qi ◽  
Cheng-Hong Zhang ◽  
Shao-Yong Zhang ◽  
Wen-Shuai Song ◽  
Wen-Sheng Xiang ◽  
...  
Keyword(s):  
Genetically Engineered ◽  
Streptomyces Avermitilis ◽  
Engineered Strain

Two new milbemycin derivatives from a genetically engineered strain Streptomyces bingchenggensis

2020 ◽  
pp. 1-6
Author(s):  
Jian-Song Li ◽  
Huan Qi ◽  
Shao-Yong Zhang ◽  
Wen-Sheng Xiang ◽  
Li-Qin Zhang ◽  
...  
Keyword(s):  
Genetically Engineered ◽  
Streptomyces Bingchenggensis ◽  
Engineered Strain

scholarly journals A Methodology to Empirically Assess National and Farm-Specific Damages from Contamination of Grain Supply by a Genetically Engineered Strain

2019 ◽  
Vol 51 (3) ◽  
pp. 495-510
Author(s):  
Oral Capps ◽  
Ronald A. Babula
Keyword(s):  
Genetically Engineered ◽  
Farm Level ◽  
Hard Wheat ◽  
Contamination Event ◽  
On Farm ◽  
The U.S ◽  
Engineered Strain ◽  
Wheat Price

AbstractOn May 29, 2013, the U.S. government announced that contamination of non–genetically engineered wheat supplies occurred. We provide a methodology to empirically assess the impacts of this contamination event on national prices and on farm-specific prices and receipts for spring red hard wheat. Results suggest that U.S. spring red hard wheat farmers in the aggregate had lost receipts ranging from $32.77 million to $131.06 million and incurred a drop of 3.83% in wheat price equivalent to $0.27 per bushel. At the farm level, ahypotheticalfarmer received $0.31 less per bushel culminating in $4,807 in lost receipts.

scholarly journals Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain.

1986 ◽  
Vol 29 (1) ◽  
pp. 13-19 ◽  
Author(s):  
S Omura ◽  
H Ikeda ◽  
F Malpartida ◽  
H M Kieser ◽  
D A Hopwood
Keyword(s):  
Genetically Engineered ◽  
Hybrid Antibiotics ◽  
Engineered Strain

scholarly journals Production enhancement of the glycopeptide antibiotic A40926 produced by an engineered N. gerenzanensis lcu1

2021 ◽  
Author(s):  
Bingyu Yan ◽  
Wen Gao ◽  
Li Tian ◽  
Shuai Wang ◽  
Huijun Dong
Keyword(s):  
Soybean Meal ◽  
Parent Strain ◽  
Medium Optimization ◽  
Genetically Engineered ◽  
Optimum Concentration ◽  
Inorganic Salts ◽  
Glycopeptide Antibiotic ◽  
Medium Components ◽  
Optimal Medium ◽  
Engineered Strain

Abstract Objective To enhance the production of A40926 by implementing a strategy of the combination of genetically engineered strain construction and medium optimization. Results The engineered strain of Nonomuraea gerenzanensis presented an increment of 30.6 percent in A40926 production compared with that of the parent strain. Subsequently, an assembling medium, which was defined as M9 medium and mainly comprised glucose, maltodextrin, soybean meal, peptone, L-valine, and other inorganic salts, was determined as the optimal medium among the tested nine media. The optimum concentration of medium components was glucose 10 g/l, maltodextrin 37.9 g/l, soybean meal 34.5 g/l, peptone 30.0 g/l, and L-valine 4.3 g/l, respectively. The optimized medium was verified experimentally, and A40926 yield increased significantly from 257 mg/l to 332 mg/l, as compared to the non-optimized medium. The strategy brought a significant increase of A40926 yield by 65.2 percent. Conclusions The engineered mutant with the genetic attributes of the co-expression of the dbv3 and dbv20 genes and the deletion of the dbv23 gene could obviously enhance the production of A40926. In addition, the optimization of medium was an effective and essential tool for the improvement of the secondary metabolites in Actinomyces.

Two new sixteen-membered macrolides from the genetically engineered strain Streptomyces avermitilis MHJ1011

2019 ◽  
Vol 34 (20) ◽  
pp. 2959-2963 ◽  
Author(s):  
Hui Zhang ◽  
You-Ling Feng ◽  
Shao-Yong Zhang ◽  
Jun Huang ◽  
Zheng-Lian Xue ◽  
...  
Keyword(s):  
Genetically Engineered ◽  
Streptomyces Avermitilis ◽  
Engineered Strain
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