Cis -acting regulation of splenic Art2 gene expression in inbred mouse strains

1999 ◽  
Vol 49 (7-8) ◽  
pp. 700-703 ◽  
Author(s):  
Deborah F. Sardinha ◽  
Thiruchandurai V. Rajan
Keyword(s):  
Gene Expression ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Cis Acting

The B4galnt2 Regulatory Polymorphism, Mvwf1, Causes Low VWF Levels and Segregates in Natural Mouse Populations

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 542-542
Author(s):  
Jill Johnsen ◽  
John Baines ◽  
Diethard Tautz ◽  
David Ginsburg
Keyword(s):  
Gene Expression ◽  
Central Region ◽  
Haplotype Block ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Regulatory Mutation ◽  
Wild Mice ◽  
Massif Central ◽  
Tissue Specific

Abstract We previously identified the cause of low levels of von Willebrand factor (VWF) in the RIIIS/J mouse strain to be a regulatory mutation, Mvwf1, in an N-acetylgalactosaminyltransferase, B4galnt2 (previously designated Galgt2). Mvwf1 causes a tissue-specific switch in B4galnt2 expression from intestinal epithelium to vascular endothelium, resulting in aberrant glycosylation of VWF and accelerated clearance from circulation. We have identified thirteen Mvwf1 inbred mouse strains that share this remarkable tissue-specific switch and a common 97kb haplotype block, including a 30kb region of 2–3% sequence divergence that flanks Exon 1. An RIIIS/J BAC transgene containing the entire Mvwf1 haplotype block and B4galnt2 gene confers vascular gene expression, while C57BL6/J BAC transgenes spanning the homologous region confer “wild-type” vessel(−), intestine(+) gene expression, indicating that one or more tissue-specific regulatory elements sufficient to recapitulate the Mvwf1 tissue-specific switch lie within the genomic region covered by these BACs. A wild-derived recombinant Mvwf1 allele containing the 3′ half of the Mvwf1 haplotype block confers the vessel(−), intestine(+) B4galnt2 expression pattern, placing the regulatory mutation(s) responsible for the Mvwf1 switch well upstream of the proximal promoter region. Sequence analysis of DNA from wild-caught individual mice confirmed the presence of a highly conserved wild mouse Mvwf1 founder allele that likely pre-dates the development of the inbred mouse strains. PCR of genomic DNA from wild caught mice representing M. m. musculus, M. m. domesticus, M. m. castaneus, M. m. molossinus, M. spretus, M. hortulanis, and M. macedonicus revealed that the Mvwf1 allele is common in wild M. m. domesticus populations in North America, Europe, and Africa, with an allele frequency as high as 60% in French mice. Population samples of M. m. domesticus from Cologne, Germany and the Massif Central region of France drastically differ in the frequency of this allele (0% vs. 60%). A significant reduction in microsatellite variability at B4galnt2 in the French population, as measured by the lnRH statistic, suggests a recent, local shift in the frequency of Mvwf1, likely due to a recent change in selective pressure. Analysis of independently trapped wild mice from the Massif Central region of France confirmed that Mvwf1 confers vascular endothelial B4galnt2 expression and causes significantly lower VWF levels (5.5+2.0 vs. 13.3+2.3, p<1x10−7) in this population. These data support a B4Galnt2 allele-specific survival advantage in wild mice, leading us to speculate that a similar survival advantage could account for the high prevalence of VWD in human populations.

scholarly journals Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains

2014 ◽  
Vol 193 (9) ◽  
pp. 4485-4496 ◽  
Author(s):  
Sara Mostafavi ◽  
Adriana Ortiz-Lopez ◽  
Molly A. Bogue ◽  
Kimie Hattori ◽  
Cristina Pop ◽  
...  
Keyword(s):  
Gene Expression ◽  
Genetic Control ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Control Of Gene Expression

scholarly journals Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes

BMC Genomics ◽  
2006 ◽  
Vol 7 (1) ◽  
Author(s):  
Michal Korostynski ◽  
Dorota Kaminska-Chowaniec ◽  
Marcin Piechota ◽  
Ryszard Przewlocki
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains

scholarly journals Differences in Mucosal Gene Expression in the Colon of Two Inbred Mouse Strains after Colonization with Commensal Gut Bacteria

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72317 ◽  
Author(s):  
Frances Brodziak ◽  
Caroline Meharg ◽  
Michael Blaut ◽  
Gunnar Loh
Keyword(s):  
Gene Expression ◽  
Inbred Mouse ◽  
Gut Bacteria ◽  
Mouse Strains ◽  
Inbred Mouse Strains

scholarly journals Differences in Caffeine 3-Demethylation Activity among Inbred Mouse Strains: A Comparison of Hepatic Cyp 1a2 Gene Expression between Two Inbred Strains

1997 ◽  
Vol 40 (2) ◽  
pp. 228-237
Author(s):  
William L. Casley ◽  
Allan Menzies ◽  
Michel Girard ◽  
Lyse Larocque ◽  
Nicole Mousseau ◽  
...  
Keyword(s):  
Gene Expression ◽  
Inbred Mouse ◽  
Inbred Strains ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Cyp 1A2 ◽  
Demethylation Activity

Ly49 Gene Expression in Different Inbred Mouse Strains

2000 ◽  
Vol 21 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Andrew P. Makrigiannis ◽  
Stephen K. Anderson
Keyword(s):  
Gene Expression ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains

scholarly journals Proinsulin I and II Gene Expression in Inbred Mouse Strains

1989 ◽  
Vol 3 (11) ◽  
pp. 1895-1902 ◽  
Author(s):  
Laszlo Koranyi ◽  
M. Alan Permutt ◽  
John M. Chirgwin ◽  
Stephen J. Giddings
Keyword(s):  
Gene Expression ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains
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