Macrophage Secretory Function Is Enhanced by Low Doses of Tributyltin-Oxide (TBTO), But Not Tributyltin-Chloride (TBTCl)

1998 ◽  
Vol 34 (3) ◽  
pp. 223-228 ◽  
Author(s):  
D. H. Kergosien ◽  
C. D. Rice
Keyword(s):  
Low Doses ◽  
Secretory Function ◽  
Tributyltin Chloride

Oral (gavage), in utero and post-natal exposure of Sprague–Dawley rats to low doses of tributyltin chloride

2004 ◽  
Vol 42 (2) ◽  
pp. 221-235 ◽  
Author(s):  
H Tryphonas ◽  
G Cooke ◽  
D Caldwell ◽  
G Bondy ◽  
M Parenteau ◽  
...  
Keyword(s):  
In Utero ◽  
Low Doses ◽  
Sprague Dawley ◽  
Oral Gavage ◽  
Sprague Dawley Rats ◽  
Tributyltin Chloride

Effects of perinatal exposure to low doses of tributyltin chloride on pregnancy outcome and postnatal development in mouse offspring

2011 ◽  
Vol 27 (10) ◽  
pp. 605-612 ◽  
Author(s):  
Jiliang Si ◽  
Jie Li ◽  
Fengmei Zhang ◽  
Guozhen Li ◽  
Quanbin Xin ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Pregnancy Outcome ◽  
Perinatal Exposure ◽  
Low Doses ◽  
Tributyltin Chloride

Perinatal exposure to low doses of tributyltin chloride reduces sperm count and quality in mice

2013 ◽  
Vol 30 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Jiliang Si ◽  
Peng Li ◽  
Quanbing Xin ◽  
Xuewen Li ◽  
Lihong An ◽  
...  
Keyword(s):  
Sperm Count ◽  
Perinatal Exposure ◽  
Low Doses ◽  
Tributyltin Chloride

Perinatal exposure to low doses of tributyltin chloride advances puberty and affects patterns of estrous cyclicity in female mice

2012 ◽  
Vol 27 (11) ◽  
pp. 662-670 ◽  
Author(s):  
Jiliang Si ◽  
Xiaoying Han ◽  
Fengmei Zhang ◽  
Quanbin Xin ◽  
Lihong An ◽  
...  
Keyword(s):  
Perinatal Exposure ◽  
Low Doses ◽  
Female Mice ◽  
Tributyltin Chloride ◽  
Estrous Cyclicity

Peripubertal exposure to low doses of tributyltin chloride affects the homeostasis of serum T, E2, LH, and body weight of male mice

2011 ◽  
Vol 26 (3) ◽  
pp. 307-314 ◽  
Author(s):  
Jiliang Si ◽  
Xuesen Wu ◽  
Chengen Wan ◽  
Tao Zeng ◽  
Miao Zhang ◽  
...  
Keyword(s):  
Body Weight ◽  
Low Doses ◽  
Male Mice ◽  
Tributyltin Chloride

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

Control of Secretory Production in the Isopod Hepatopancreas

1972 ◽  
Vol 30 ◽  
pp. 166-167
Author(s):  
John W. Roberts ◽  
E. R. Witkus
Keyword(s):  
B Cells ◽  
Morphological Data ◽  
Secretory Product ◽  
Secretory Function ◽  
Secretory Material ◽  
Blind Ending ◽  
Secretory Production ◽  
Regenerative Cells ◽  
Immature Cells ◽  
And Storage

The isopod hepatopancreas, as exemplified by Oniscus ascellus. is comprised of four blind-ending diverticula. The regenerative cells at the tip of each diverticula differentiate into either club-shaped B-cells, which serve a secretory function, or into conoid S-cells, which serve in the absorption and storage of nutrients.The glandular B-cells begin producing secretory material with the development of rough endoplasmic reticulum during their process of maturation from the undifferentiated regenerative cells. Cytochemical and morphological data indicate that the hepatopancreas sequentially produces two types of secretory material within the large club-shaped cells. The production of the carbohydrate-like secretory product in immature cells seems to be phased out as the production of the osmiophilic secretion was phased in as the cell matured.

The Effect of Androgen Depletion and Replacement on the Epithelium of the Seminal Vesicle of the Aging Rat

1975 ◽  
Vol 33 ◽  
pp. 590-591
Author(s):  
Venita F. Allison
Keyword(s):  
Cell Proliferation ◽  
Seminal Vesicle ◽  
Male Rats ◽  
Target Cells ◽  
Cell Regeneration ◽  
Secretory Function ◽  
Electron Microscopic ◽  
Aging Rat ◽  
Microscopic Studies ◽  
Androgen Depletion

In 1930, Moore, Hughes and Gallager reported that after castration seminal vesicle epithelial cell atrophy occurred and that cell regeneration could be achieved with daily injections of testis extract. Electron microscopic studies have confirmed those observations and have shown that testosterone injections restore the epithelium of the seminal vesicle in adult castrated male rats. Studies concerned with the metabolism of androgens point out that dihydrotestosterone stimulates cell proliferation and that other metabolites of testosterone probably influence secretory function in certain target cells.Although the influence of androgens on adult seminal vesicle epithelial cytology is well documented, little is known of the effect of androgen depletion and replacement on those cells in aging animals. The present study is concerned with the effect of castration and testosterone injection on the epithelium of the seminal vesicle of aging rats.

Potentiation of bromotrichloromethane hepatotoxicity in male rats exposed to 10 ppm dietary chlordecone: Electron Microscopic and biochemical study

1990 ◽  
Vol 48 (3) ◽  
pp. 284-285
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale
Keyword(s):  
Free Radical ◽  
Biochemical Study ◽  
Prior Exposure ◽  
Male Rats ◽  
Cellular Injury ◽  
Low Doses ◽  
Mixed Function Oxidase ◽  
Electron Microscopic ◽  
Potent Inducer ◽  
Cellular Energy

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.

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