The Codon-Degeneracy Model of Molecular Evolution

2000 ◽  
Vol 50 (2) ◽  
pp. 131-140 ◽  
Author(s):  
David A. McClellan
Keyword(s):  
Molecular Evolution ◽  
Codon Degeneracy

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

Sign in / Sign up

Export Citation Format

Share Document