Calcium hydroxyapatite deposition disease in the hand and wrist: a report of six cases

1998 ◽  
Vol 21 (7) ◽  
pp. 366-369 ◽  
Author(s):  
S. Stahl ◽  
T. Kaufman ◽  
D. Schapira
Author(s):  
Josephina A. Vossen

Chapter 37 discusses calcific hydroxyapatite deposition disease (HADD). Hydroxyapatite (HA) crystal deposition disease is a systemic disease of unknown etiology that is caused by periarticular and/or intraarticular deposition of HA crystals. The shoulder is the most commonly involved joint with calcification in the supraspinatus tendon, but not all patients with HADD are symptomatic. Radiography is the main diagnostic tool for HADD, which may show calcifications of varying size and shape in the periarticular tendons, bursae, and joint capsule with joint destruction. Ultrasound can be useful in evaluation and image-guided treatment of calcific tendinitis.


2019 ◽  
Vol 120 ◽  
pp. 108653 ◽  
Author(s):  
Patcharee Hongsmatip ◽  
Karen Y. Cheng ◽  
Christopher Kim ◽  
David A. Lawrence ◽  
Robert Rivera ◽  
...  

2003 ◽  
Vol 5 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Eamonn S. Molloy ◽  
Geraldine M. McCarthy

2021 ◽  
pp. 030098582110206
Author(s):  
Kazuya Takehana ◽  
Anneke Moresco ◽  
James G. Johnson ◽  
Masaaki Kasahara ◽  
Norio Kasahara ◽  
...  

In a collection of 6 young binturongs ( Arctictis binturong), 3 presented with anorexia, lethargy, and footpad swelling diagnosed by surgical biopsy as calcinosis circumscripta. Despite supportive care over the next 4 years, affected binturongs had progressive weight loss, hyperphosphatemia, and hyperkalemia and developed large radiodense deposits in tissues adjacent to appendicular joints, thoracolumbar vertebrae, and the sternum. Two binturongs died and necropsies showed severe periarticular mineral deposition with fibrosis and granulomatous inflammation. Additionally, binturongs had mineralization of distal renal tubules, mineralization of the renal interstitium, and marked mineralization of the pulmonary interstitium and peribronchiolar smooth muscle. Foot biopsies from the surviving binturong were evaluated by spectroscopic microanalysis and were positive for hydroxyapatite, Ca10(PO4)6(OH)2. Periarticular and footpad mineralization in these binturongs is consistent with hydroxyapatite deposition disease, which is rarely described in humans and animals as a primary familial condition or a secondary condition often associated with renal injury.


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