Morbidity of iliac crest donor site in cleft lip and palate infants

2000 ◽  
Vol 23 (7) ◽  
pp. 366-368 ◽  
Author(s):  
I. T. Jackson ◽  
J. Yousefi ◽  
R. Yavuzer ◽  
G. Yavuzer
Keyword(s):  
Cleft Lip ◽  
Iliac Crest ◽  
Cleft Lip And Palate ◽  
Donor Site

Iliac Crest Donor Site for Children With Cleft Lip and Palate Undergoing Alveolar Bone Grafting

2016 ◽  
Vol 27 (3) ◽  
pp. 598-601 ◽  
Author(s):  
Jonathan Wheeler ◽  
Megan Sanders ◽  
Stanley Loo ◽  
Zac Moaveni ◽  
Glenn Bartlett ◽  
...  
Keyword(s):  
Bone Grafting ◽  
Cleft Lip ◽  
Iliac Crest ◽  
Cleft Lip And Palate ◽  
Alveolar Bone ◽  
Donor Site ◽  
Alveolar Bone Grafting

Alveolar Bone Grafting: Donor Site Review of 100 Consecutive Cases in Cleft Lip and Palate

2017 ◽  
Vol 54 (2) ◽  
pp. 137-141 ◽  
Author(s):  
Kavit Amin ◽  
Wee Sim Khor ◽  
Anais Rosich-Medina ◽  
Victoria Beale
Keyword(s):  
Bone Grafting ◽  
Cleft Lip ◽  
Iliac Crest ◽  
Cleft Lip And Palate ◽  
Alveolar Bone ◽  
Donor Site ◽  
Oral Morphine ◽  
Unknown Origin ◽  
Pyrexia Of Unknown Origin ◽  
Alveolar Bone Grafting

Objective Review of patients who underwent secondary alveolar bone grafting for total inpatient stay, postoperative complications, and postoperative analgesic requirements. Design Retrospective analysis of medical records. Setting Tertiary care center as part of a regional cleft lip and palate network. Patients All patients who underwent secondary alveolar bone grafting from the iliac crest. Interventions Local anesthetic was infiltrated overlying the anterior iliac crest. An incision was made to conform to the future skin crease and avoid muscle dissection. The cartilaginous cap was incised and raised, and cancellous bone was then harvested. The cavity was packed with hemostatic cellulose and closed in layers. All patients received postoperative antibiotics. All patients were prescribed regular paracetamol (acetaminophen) and ibuprofen if there were no contraindications. Oral morphine was available when requested. Main Outcome Measures Length of stay, postoperative analgesic requirements, and postoperative donor site and oral complications. Results From 100 consecutive patients, 92 (92%) of the patients were discharged the day after surgery; one (1%) patient required four nights of monitoring for postoperative pyrexia of unknown origin. All patients received regular paracetamol, and the majority (86%) did not require oral morphine. Complications included seroma (4%), superficial donor site abscess (1%), postoperative pyrexia of unknown origin (2%), gingival bleeding (2%), and oral infection (2%). Conclusion The findings suggest that donor site pain may be well controlled with simple, regular analgesia. Children tolerated this procedure well and were safely discharged the day after surgery. Alveolar bone grafting from the iliac crest was found to have low complication rates.

Combined Surgical/Orthodontic Treatment and Autotransplantation of a Premolar in a Patient with Unilateral Cleft Lip and Palate

2004 ◽  
Vol 41 (4) ◽  
pp. 447-455 ◽  
Author(s):  
Stijn De Muynck ◽  
Anna Verdonck ◽  
Joseph Schoenaers ◽  
Carine Carels
Keyword(s):  
Orthodontic Treatment ◽  
Cleft Lip ◽  
Iliac Crest ◽  
Cleft Lip And Palate ◽  
Autologous Bone Graft ◽  
Alveolar Process ◽  
End Of Treatment ◽  
The Status ◽  
One Year ◽  
Lower Premolar

Objective The treatment of a patient with a complete unilateral left cleft lip and palate, agenesis of the left upper second premolar, and a severely malformed left upper lateral incisor is reported. Treatment included placement of an autologous bone graft from the left iliac crest into the alveolar cleft at 8 years of age and transplantation of a lower premolar into the reconstructed alveolar process at 10 years of age. During the succeeding orthodontic treatment, the dental arches were aligned and corrected toward a Class I molar occlusion. One year after the end of treatment, the status of the transplanted premolar was good.

Alveolar Bone Graft: Clinical Profile and Risk Factors for Complications in Oral Cleft Patients

2017 ◽  
Vol 54 (5) ◽  
pp. 530-534 ◽  
Author(s):  
Macedo Pessoa Erica Alexandra ◽  
Braune Andre ◽  
Ladeira Casado Priscila ◽  
Nivoloni Tannure Patricia
Keyword(s):  
Postoperative Complications ◽  
Bone Graft ◽  
Cleft Lip ◽  
Iliac Crest ◽  
Cleft Lip And Palate ◽  
Alveolar Bone ◽  
Maxillofacial Surgery ◽  
Clinical Aspects ◽  
Graft Material ◽  
Oral Cleft

Objective The aim of this study was to investigate clinical aspects and predisposing factors for alveolar bone graft complications in persons born with oral clefts. Design A total of 105 patients, aged 7 to 57 years old, who received alveolar bone graft at the Cranio-maxillofacial Surgery Center in the National Institute of Traumatology and Orthopedics (INTO), Rio de Janeiro (RJ) from 2009 to 2014 were selected. Data were collected concerning the type of oral cleft, family history of cleft, medical and dental exam, donor area, type of graft material, repaired surgical treatment done, and postoperative follow-up examinations. Results Postoperative complications developed in 31 patients (32.9%). The mean age at grafting was 16.79 years for the group without complications (n = 63) and 20.13 years for the group with postoperative complications (n = 31). There was a positive association between age and type of graft and cases with alveolar bone graft complications. Patients aged 12 years or more had a four times more chance of developing alveolar bone graft complications. Particulate bone graft from iliac crest demonstrated better results compared with block graft or mixed graft. Conclusion Patients with cleft lip and palate who were 12 years or older had a greater chance of developing complications after grafting the alveolar bone. Furthermore, particulate alveolar graft from iliac crest had significantly better outcomes.

Bilateral Superiorly Based Full-Thickness Nasolabial Island Flaps for Closure of Residual Anterior Palatal Fistulas in an Unoperated Elderly Patient

2003 ◽  
Vol 40 (1) ◽  
pp. 91-99 ◽  
Author(s):  
A.R. Erçöçen ◽  
S. Yilmaz ◽  
M. Saydam
Keyword(s):  
Elderly Patient ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Retrograde Flow ◽  
Full Thickness ◽  
Knowledge Based ◽  
Straight Line ◽  
Pharyngeal Flap

Objective Unoperated bilateral complete cleft lip and palate in an adult or elderly patient is seen rarely, and the existence of unoperated clefts is a result of unfavorable economic and social circumstances. We report an unoperated 65-year-old patient with bilateral complete cleft lip and palate and present our preference for the surgical management. Interventions Repair of the bilateral complete cleft lip and palate was successfully carried out using straight-line closure for the bilateral cleft lip and two-flap pushback palatoplasty with superiorly based lateral port control pharyngeal flap for the wide cleft palate at the first stage, and large residual anterior palatal fistulas were closed using bilateral superiorly based (retrograde flow) full-thickness nasolabial island flaps at the second stage. Conclusions To our knowledge based on a review of the literature, this is the first report of an elderly patient with bilateral complete cleft lip and palate and the first application of bilateral superiorly based (retrograde flow) full-thickness nasolabial island flaps for closure of large residual anterior palatal fistulas or alveolar clefts. The bilateral superiorly based (retrograde flow) full-thickness nasolabial island flap may be a good solution in large anterior palatal defects using unilaterally or bilaterally in a single stage with minimal donor site morbidity, in which there is not enough tissue for local repair or if previous attempts are unsuccessful.

scholarly journals A Synonymous Exonic Splice Silencer Variant in IRF6 as a Novel and Cryptic Cause of Non-Syndromic Cleft Lip and Palate

Genes ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 903
Author(s):  
Beau Sylvester ◽  
Frederick Brindopke ◽  
Akiko Suzuki ◽  
Melissa Giron ◽  
Allyn Auslander ◽  
...  
Keyword(s):  
Splice Site ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Donor Site ◽  
Regulatory Region ◽  
Ectopic Expression ◽  
Incomplete Penetrance ◽  
Exonic Splice Silencer ◽  
Exonic Splice ◽  
Synonymous Variant

Missense, nonsense, splice site and regulatory region variants in interferon regulatory factor 6 (IRF6) have been shown to contribute to both syndromic and non-syndromic forms of cleft lip and/or palate (CL/P). We report the diagnostic evaluation of a complex multigeneration family of Honduran ancestry with a pedigree structure consistent with autosomal-dominant inheritance with both incomplete penetrance and variable expressivity. The proband’s grandmother bore children with two partners and CL/P segregates on both sides of each lineage. Through whole-exome sequencing of five members of the family, we identified a single shared synonymous variant, located in the middle of exon 7 of IRF6 (p.Ser307Ser; g.209963979 G>A; c.921C>T). The variant was shown to segregate in the seven affected individuals and through three unaffected obligate carriers, spanning both sides of this pedigree. This variant is very rare, only being found in three (all of Latino ancestry) of 251,352 alleles in the gnomAD database. While the variant did not create a splice acceptor/donor site, in silico analysis predicted it to impact an exonic splice silencer element and the binding of major splice regulatory factors. In vitro splice assays supported this by revealing multiple abnormal splicing events, estimated to impact >60% of allelic transcripts. Sequencing of the alternate splice products demonstrated the unmasking of a cryptic splice site six nucleotides 5′ of the variant, as well as variable utilization of cryptic splice sites in intron 6. The ectopic expression of different splice regulatory proteins altered the proportion of abnormal splicing events seen in the splice assay, although the alteration was dependent on the splice factor. Importantly, each alternatively spliced mRNA is predicted to result in a frame shift and prematurely truncated IRF6 protein. This is the first study to identify a synonymous variant as a likely cause of NS-CL/P and highlights the care that should be taken by laboratories when considering and interpreting variants.

Sign in / Sign up

Export Citation Format

Share Document