Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter changes

1998 ◽  
Vol 40 (3) ◽  
pp. 131-137 ◽  
Author(s):  
H. Tohgi ◽  
H. Yonezawa ◽  
S. Takahashi ◽  
N. Sato ◽  
E. Kato ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Vascular Dementia ◽  
Senile Dementia ◽  
Oxygen Metabolism ◽  
White Matter Changes ◽  
Deep White Matter ◽  
Dementia Of Alzheimer’S Type

scholarly journals Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis

2020 ◽  
Vol 41 (1) ◽  
pp. 182-193 ◽  
Author(s):  
Kathryn L West ◽  
Dinesh K Sivakolundu ◽  
Mark D Zuppichini ◽  
Monroe P Turner ◽  
Jeffrey S Spence ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Motor Cortex ◽  
Healthy Volunteers ◽  
Primary Motor Cortex ◽  
Motor Impairment ◽  
Oxygen Metabolism ◽  
Button Press

The neural mechanisms underlying motor impairment in multiple sclerosis (MS) remain unknown. Motor cortex dysfunction is implicated in blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies, but the role of neural–vascular coupling underlying BOLD changes remains unknown. We sought to independently measure the physiologic factors (i.e., cerebral blood flow (ΔCBF), cerebral metabolic rate of oxygen (ΔCMRO2), and flow–metabolism coupling (ΔCBF/ΔCMRO2), utilizing dual-echo calibrated fMRI (cfMRI) during a bilateral finger-tapping task. We utilized cfMRI to measure physiologic responses in 17 healthy volunteers and 32 MS patients (MSP) with and without motor impairment during a thumb-button-press task in thumb-related (task-central) and surrounding primary motor cortex (task-surround) regions of interest (ROIs). We observed significant ΔCBF and ΔCMRO2 increases in all MSP compared to healthy volunteers in the task-central ROI and increased flow–metabolism coupling (ΔCBF/ΔCMRO2) in the MSP without motor impairment. In the task-surround ROI, we observed decreases in ΔCBF and ΔCMRO2 in MSP with motor impairment. Additionally, ΔCBF and ΔCMRO2 responses in the task-surround ROI were associated with motor function and white matter damage in MSP. These results suggest an important role for task-surround recruitment in the primary motor cortex to maintain motor dexterity and its dependence on intact white matter microstructure and neural–vascular coupling.

scholarly journals Cerebral blood flow and oxygen metabolism in patients with vascular dementia of the Binswanger type.

Stroke ◽  
1990 ◽  
Vol 21 (12) ◽  
pp. 1694-1699 ◽  
Author(s):  
H Yao ◽  
S Sadoshima ◽  
Y Kuwabara ◽  
Y Ichiya ◽  
M Fujishima
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Vascular Dementia ◽  
Oxygen Metabolism

scholarly journals Acupuncture improves white matter perfusion and white matter integrity in vascular dementia rats: an MRI-based imaging study

2020 ◽  
Author(s):  
Siming Ma ◽  
Lu Wang ◽  
Xin-Tong Su ◽  
Jin Huang ◽  
Lu-Lu Lin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
White Matter ◽  
Vascular Dementia ◽  
Acupuncture Treatment ◽  
Diffusion Tensor ◽  
White Matter Lesions ◽  
Microglia Activation ◽  
White Matter Integrity

Abstract Background: White matter lesions induced by chronic cerebral hypoperfusion (CCH) are common pathological changes, and are associated with cognitive impairment in vascular dementia (VaD). It has been reported that acupuncture can improve cognitive deficits of VaD rats through increasing cortical cerebral blood flow and attenuating neuroinflammation. However, the effects of acupuncture on white matter perfusion and white matter structural integrity have been not investigated. Methods: VaD was induced by bilateral common carotid arteries occlusion (BCCAO) in Wistar rats. Morris water maze (MWM) was used to evaluated the spatial learning and memory of rats. Arterial spin labeling imaging (ASL) and diffusion tensor imaging (DTI) were performed to measure the cerebral blood flow and white matter integrity in corpus callosum, external capsule, internal capsule, optic nerve and optic tract. Pathological staining was also applied to detect the myelin loss and neuroinflammation. Results: BCCAO rats with declined cerebral blood flow exhibited significant worse MWM performance, and altered DTI parameters including decreased fractional anisotropy, elevated radial diffusivity and axial diffusivity in white matter regions. After acupuncture treatment at GV20 and ST36, cognitive dysfunction, disruption of white matter perfusion and integrity were reversed. Pathological results supported that acupuncture could attenuate the loss of myelin sheath and microglia activation. Conclusions: Our findings suggest that acupuncture treatment protects cognitive impairment of BCCAO rats through increasing subcortical white matter perfusion and improving white matter lesions. Keywords: Acupuncture; ASL; DTI; cerebral blood flow; white matter; microglia activation

Pentobarbital changes compartmental contribution to cerebral blood flow

1982 ◽  
Vol 56 (4) ◽  
pp. 504-510 ◽  
Author(s):  
John P. Laurent ◽  
Pablo Lawner ◽  
Frederick A. Simeone ◽  
Eugene Fink
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Intracranial Pressure ◽  
Content Type ◽  
Deep White Matter ◽  
Percentage Contribution ◽  
Blood Flows ◽  
Xenon 133 ◽  
Fine Print

✓ Barbiturates were administered to normal dogs, establishing an isoelectric electrocorticogram. Cortical cerebral blood flows (CBF) and deeper CBF's were respectively measured by krypton-85 (85Kr) and xenon-133 (133Xe). Following barbiturate administration, the two methods of measuring CBF showed a poor coefficient of variation (r = 0.12, p < 0.05). The cortical flows decreased less than the fast compartment flows. A shifting of percentage contribution of flow to the slow compartment (60% increase, p < 0.001) was observed after barbiturate infusion. A selective shunting of blood flow to the slower areas may explain the lowering of intracranial pressure and protection of the deep white matter observed by many authors who use barbiturates in clinical and experimental situations.

Decline in Total Cerebral Blood Flow Is Linked with Increase in Periventricular but Not Deep White Matter Hyperintensities

Radiology ◽  
2007 ◽  
Vol 243 (1) ◽  
pp. 198-203 ◽  
Author(s):  
V. Hester ten Dam ◽  
Dominique M. J. van den Heuvel ◽  
Anton J. M. de Craen ◽  
Edward L. E. M. Bollen ◽  
Heather M. Murray ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Deep White Matter

scholarly journals Vascular dementia from a viewpoint of cerebral blood flow and oxygen metabolism

2003 ◽  
Vol 3 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Makoto Tanaka ◽  
Susumu Kondo ◽  
Koichi Okamoto ◽  
Shunsaku Hirai
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Vascular Dementia ◽  
Oxygen Metabolism

scholarly journals Silent infarcts in sickle cell disease occur in the border zone region and are associated with low cerebral blood flow

Blood ◽  
2018 ◽  
Vol 132 (16) ◽  
pp. 1714-1723 ◽  
Author(s):  
Andria L. Ford ◽  
Dustin K. Ragan ◽  
Slim Fellah ◽  
Michael M. Binkley ◽  
Melanie E. Fields ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Sickle Cell Disease ◽  
Border Zone ◽  
Cell Disease ◽  
Deep White Matter ◽  
Parietal Lobes ◽  
Key Points ◽  
Density Map

Key Points The SCI density map revealed key SCI locations in the deep white matter of the frontal and parietal lobes. Peak SCI density occurs in the region of nadir cerebral blood flow.

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