Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance

1999 ◽  
Vol 54 (12) ◽  
pp. 943-946 ◽  
Author(s):  
O. Spigset ◽  
S. Hägg ◽  
E. Söderström ◽  
R. Dahlqvist
Keyword(s):  
Cyp1a2 Activity ◽  
Caffeine Clearance

Impact of Smoking, Smoking Cessation, and Genetic Polymorphisms on CYP1A2 Activity and Inducibility

2011 ◽  
Vol 90 (1) ◽  
pp. 117-125 ◽  
Author(s):  
M Dobrinas ◽  
J Cornuz ◽  
B Oneda ◽  
M Kohler Serra ◽  
M Puhl ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Genetic Polymorphisms ◽  
Cyp1a2 Activity

Diurnal Effect on Caffeine Clearance

1992 ◽  
Vol 32 (2) ◽  
pp. 184-187 ◽  
Author(s):  
Masayuki Hashiguchi ◽  
Akio Fujimura ◽  
Kyo-ichi Ohashi ◽  
Akio Ebihara
Keyword(s):  
Diurnal Effect ◽  
Caffeine Clearance

Serum and salivary caffeine clearance in cirrhosis. Any role in selection for surgery and timing for transplantation?

1993 ◽  
Vol 18 (1) ◽  
pp. 135-136 ◽  
Author(s):  
Fabio Farinati ◽  
Lucia Dalri' ◽  
Lorenzo Rossaro ◽  
Mario Plebani ◽  
Lucia Nemetz ◽  
...  
Keyword(s):  
Selection For ◽  
Caffeine Clearance

Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine

1999 ◽  
Vol 9 (6) ◽  
pp. 725???734 ◽  
Author(s):  
J??rgen Schmider ◽  
J??rgen Brockm??ller ◽  
Gerhard Arold ◽  
Steffen Bauer ◽  
Ivar Roots
Keyword(s):  
Cyp1a2 Activity ◽  
Simultaneous Assessment

scholarly journals The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3174 ◽  
Author(s):  
Mirza Bojić ◽  
Martin Kondža ◽  
Hrvoje Rimac ◽  
Goran Benković ◽  
Željan Maleš
Keyword(s):  
Enzyme Activity ◽  
High Performance ◽  
Cytochromes P450 ◽  
Docking Study ◽  
Reversible Inhibitor ◽  
Reversible Inhibitors ◽  
Flavonoid Aglycones ◽  
Cyp1a2 Activity ◽  
Array Detection ◽  
Cyp3a4 Enzyme

Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed. Flavonoids are natural compounds to which humans are exposed through everyday diet. In the previous study, selected flavonoid aglycones showed inhibition of CYP3A4 enzyme. Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes. For this purpose, the O-deethylation reaction of phenacetin was used for monitoring CYP1A2 enzyme activity, coumarin 7-hydroxylation for CYP2A6 enzyme activity, 6-α-hydroxylation of paclitaxel for CYP2C8 enzyme activity, and dextromethorphan O-demethylation for CYP2D6 enzyme activity. The generated metabolites were monitored by high-performance liquid chromatography coupled with diode array detection. Hesperetin, pinocembrin, chrysin, isorhamnetin, and morin inhibited CYP1A2 activity; apigenin, tangeretin, galangin, and isorhamnetin inhibited CYP2A6 activity; and chrysin, chrysin-dimethylether, and galangin inhibited CYP2C8. None of the analyzed flavonoids showed inhibition of CYP2D6. The flavonoids in this study were mainly reversible inhibitors of CYP1A2 and CYP2A6, while the inhibition of CYP2C8 was of mixed type (reversible and irreversible). The most prominent reversible inhibitor of CYP1A2 was chrysin, and this was confirmed by the docking study.

Hepatic metabolism in severe falciparum malaria: caffeine clearance study

1994 ◽  
Vol 88 (1) ◽  
pp. 13-19 ◽  
Author(s):  
P. Wilairatana ◽  
S. Looareesuwan ◽  
S. Vanijanonta ◽  
P. Charoenlarp ◽  
S. Wittayalertpanya
Keyword(s):  
Falciparum Malaria ◽  
Hepatic Metabolism ◽  
Caffeine Clearance ◽  
Severe Falciparum Malaria ◽  
Clearance Study

Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2

2016 ◽  
Vol 100 (6) ◽  
pp. 606-616 ◽  
Author(s):  
J Matthaei ◽  
MV Tzvetkov ◽  
J Strube ◽  
D Sehrt ◽  
C Sachse-Seeboth ◽  
...  
Keyword(s):  
Environmental Effects ◽  
Genetic Effects ◽  
Cyp1a2 Activity ◽  
Caffeine Metabolism
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