Digitoxin intoxication during concomitant use of amiodarone

1998 ◽  
Vol 54 (1) ◽  
pp. 95-96 ◽  
Author(s):  
S. L�er ◽  
H. Scholz ◽  
I. Buschmann ◽  
M. Thoenes ◽  
T. Meinertz
Keyword(s):  
Digitoxin Intoxication

Digitoxin Intoxication in a Woman with Normal Heart

Cardiology ◽  
1950 ◽  
Vol 15 (6) ◽  
pp. 357-364 ◽  
Author(s):  
Åke Liljestrand
Keyword(s):  
Normal Heart ◽  
Digitoxin Intoxication

Successful Treatment of Severe Digitoxin Intoxication with CytoSorb® Hemoadsorption

2020 ◽  
pp. 1-4
Author(s):  
Thomas Georg Karl Breuer ◽  
Daniel Robert Quast ◽  
Stephan Wiciok ◽  
Adnan Labedi ◽  
Gisa Ellrichmann
Keyword(s):  
Renal Failure ◽  
Intensive Therapy ◽  
Plasma Concentrations ◽  
Clinical Signs ◽  
Stable Condition ◽  
Drug Level ◽  
Steroid Glycoside ◽  
Elimination Kinetics ◽  
Fab Fragment ◽  
Digitoxin Intoxication

While several intoxications can be successfully treated with specific antidotes, intoxications with the steroid glycoside digitoxin still represent a major challenge. Besides conventional approaches, CytoSorb® hemoadsorption might be another treatment option. We report on an 81-year-old female patient treated in our intensive care unit (ICU) with severe digitoxin intoxication, acute renal failure, and urinary tract infection (UTI). As physiological digitoxin elimination kinetics are known to appear slow, and also in regard to the renal failure, the decision was made to initiate continuous renal replacement therapy combined with CytoSorb hemoadsorption. The patient was hemodynamically stabilized within the first 4 h of treatment and initially required catecholamines to be stopped within 24 h of treatment. Pre- and post-adsorber drug level measurements showed a rapid elimination of digitoxin. Antibiotic treatment with piperacillin/tazobactam was initiated, and despite CytoSorb hemoadsorption therapy and its known potential to reduce plasma concentrations of several drugs, the UTI was successfully treated. After 3 days of CytoSorb treatment, digitoxin plasma levels were stable and almost normalized, and no clinical signs of intoxication were present. Five days after presentation, the patient was transferred from the ICU in a stable condition. CytoSorb hemoadsorption may be an easily available, efficient, and less cost-intensive therapy option than treatment with the Fab fragment, which is the currently recommended therapy for digitalis intoxications. Therefore, the use of CytoSorb might represent an alternative treatment for life-threatening complications of digitoxin intoxications.

Digitoxin intoxication

Reactions ◽  
1981 ◽  
Vol 32 (1) ◽  
pp. 4-5
Keyword(s):  
Digitoxin Intoxication

scholarly journals Large-scale Digitoxin Intoxication

BMJ ◽  
1970 ◽  
Vol 3 (5725) ◽  
pp. 737-740 ◽  
Author(s):  
A. H. Lely ◽  
C. H. J. Van Enter
Keyword(s):  
Large Scale ◽  
Digitoxin Intoxication

scholarly journals Accidental digitoxin intoxication: an interplay between laboratory and clinical medicine

2012 ◽  
pp. 380-384 ◽  
Author(s):  
Luigi M. Castello ◽  
Sophie Negro ◽  
Francesca Santi ◽  
Isabella Zanotti ◽  
Matteo Vidali ◽  
...  
Keyword(s):  
Clinical Medicine ◽  
Digitoxin Intoxication

Acute Digitoxin Intoxication Treated by Intracardiac Pacemaker: Experience in Sixty-Eight Patients

1977 ◽  
Vol 10 (4) ◽  
pp. 443-456 ◽  
Author(s):  
CHANTAL BISMUTH ◽  
GILBERT MOTTE ◽  
FRANÇOISE CONSO ◽  
MICHEL CHAUVIN ◽  
MICHEL GAULTIER
Keyword(s):  
Digitoxin Intoxication

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child

1994 ◽  
Vol 15 (1) ◽  
pp. 48-49 ◽  
Author(s):  
K. Schmitt ◽  
G. Tulzer ◽  
F. H�ckel ◽  
R. Sommer ◽  
W. Tulzer
Keyword(s):  
Specific Antibodies ◽  
Digitoxin Intoxication

Massive digitoxin intoxication. Treatment by amberlite XAD 4 resin hemoperfusion

1982 ◽  
Vol 19 (9) ◽  
pp. 931-950 ◽  
Author(s):  
D. Mathieu ◽  
B. Gosselin ◽  
M. Nolf ◽  
B. Dupuis ◽  
X. Marchandise ◽  
...  
Keyword(s):  
Digitoxin Intoxication
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