Amlodipine lowers blood pressure without increasing sympathetic activity or activating the renin-angiotensin system in patients with essential hypertension

1997 ◽  
Vol 53 (3-4) ◽  
pp. 197-201 ◽  
Author(s):  
M. Sasaguri ◽  
N. Matsumoto ◽  
K. Noda ◽  
M. Koga ◽  
A. Kinoshita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Sympathetic Activity ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Effects of Nitrendipine on Blood Pressure, Renin-Angiotensin System, and Kidney Function in Essential Hypertension

1988 ◽  
Vol 12 ◽  
pp. S142-S145 ◽  
Author(s):  
Nicola Glorioso ◽  
Paolo Manunta ◽  
Chiara Troffsa ◽  
Antonio Pazzola ◽  
Aldo Soro ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Kidney Function ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Genetic variants of the renin–angiotensin system and ambulatory blood pressure in essential hypertension

1997 ◽  
Vol 15 (5) ◽  
pp. 503-508 ◽  
Author(s):  
Joachim Beige ◽  
Oliver Zilch ◽  
Henriette Hohenbleicher ◽  
Jens Ringel ◽  
Regina Kunz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Ambulatory Blood Pressure ◽  
Genetic Variants ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Terlipressin Versus  Norepinephrine to Correct Refractory Arterial Hypotension after General Anesthesia in Patients Chronically Treated with Renin-Angiotensin System Inhibitors

2003 ◽  
Vol 98 (6) ◽  
pp. 1338-1344 ◽  
Author(s):  
Gilles Boccara ◽  
Alexandre Ouattara ◽  
Gilles Godet ◽  
Eric Dufresne ◽  
Michèle Bertrand ◽  
...  
Keyword(s):  
Blood Pressure ◽  
General Anesthesia ◽  
Arterial Blood Pressure ◽  
Renin Angiotensin System ◽  
Arterial Hypotension ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Arterial Blood ◽  
Long Term Treatment ◽  
Systolic Arterial Blood Pressure

Background Terlipressin, a precursor that is metabolized to lysine-vasopressin, has been proposed as a drug for treatment of intraoperative arterial hypotension refractory to ephedrine in patients who have received long-term treatment with renin-angiotensin system inhibitors. The authors compared the effectiveness of terlipressin and norepinephrine to correct hypotension in these patients. Methods Among 42 patients scheduled for elective carotid endarterectomy, 20 had arterial hypotension following general anesthesia that was refractory to ephedrine. These patients were the basis of the study. After randomization, they received either 1 mg intravenous terlipressin (n = 10) or norepinephrine infusion (n = 10). Beat-by-beat recordings of systolic arterial blood pressure and heart rate were stored on a computer. The intraoperative maximum and minimum values of blood pressure and heart rate, and the time spent with systolic arterial blood pressure below 90 mmHg and above 160 mmHg, were used as indices of hemodynamic stability. Data are expressed as median (95% confidence interval). Results Terlipressin and norepinephrine corrected arterial hypotension in all cases. However, time spent with systolic arterial blood pressure below 90 mmHg was less in the terlipressin group (0 s [0-120 s] vs. 510 s [120-1011 s]; P < 0.001). Nonresponse to treatment (defined as three boluses of terlipressin or three changes in norepinephrine infusion) occurred in zero and eight cases (P < 0.05), respectively. Conclusions In patients who received long-term treatment with renin-angiotensin system inhibitors, intraoperative refractory arterial hypotension was corrected with both terlipressin and norepinephrine. However, terlipressin was more rapidly effective for maintaining normal systolic arterial blood pressure during general anesthesia.

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