Comparison between concentrations of racemic mefloquine, its separate enantiomers and the carboxylic acid metabolite in whole blood serum and plasma

1996 ◽  
Vol 51 (2) ◽  
pp. 171-173 ◽  
Author(s):  
U. Hellgren ◽  
J. Jastrebova ◽  
M. Jerling ◽  
B. Krysén ◽  
Y. Bergqvist
Keyword(s):  
Carboxylic Acid ◽  
Blood Serum ◽  
Whole Blood ◽  
Acid Metabolite

Comparison of Whole Blood and Serum Levels of Mefloquine and Its Carboxylic Acid Metabolite

1997 ◽  
Vol 57 (4) ◽  
pp. 399-402 ◽  
Author(s):  
G. Daniel Todd ◽  
Adriaan P. C. C. Hopperus Buma ◽  
Michael D. Green ◽  
Christiaan A. J. J. Jaspers ◽  
Hans O. Lobel
Keyword(s):  
Carboxylic Acid ◽  
Whole Blood ◽  
Serum Levels ◽  
Acid Metabolite

Antiheparin Activity of Human Serum and Platelet Factor 4

1973 ◽  
Vol 30 (01) ◽  
pp. 093-105 ◽  
Author(s):  
C.H.J Sear ◽  
L Poller ◽  
F.R.C Path
Keyword(s):  
Molecular Weight ◽  
Ionic Strength ◽  
Blood Serum ◽  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Gel Filtration ◽  
Normal Serum ◽  
Platelet Factor ◽  
Mean Values ◽  
Antiheparin Activity

SummaryThe antiheparin activity of normal serum has been studied by comparing the antiheparin activities of sera obtained from normal whole blood, platelet-rich plasma and platelet-’free’ plasma with a purified platelet extract during differential isoelectric precipitation and by gel filtration chromatography.The mean values for the activity of PRP-serum and PFP-serum were 106% (S.D. 11) and 10% (S.D. 3) of untreated whole blood respectively. The activity of whole blood serum, PRP serum and whole blood serum plus platelet extract precipitated under identical physical conditions, i.e. pH 7.0, I =0.008, indicating that the activities of the three samples are probably associated with PF4. PF4 precipitated from human platelet extract at pH 4.0, but this is probably due to the difference in the two biochemical environments investigated, i.e. serum and platelet extract.The gel filtration experiments revealed striking similarities between the major antiheparin activities of serum and platelet extract. At physiological pH and ionic strength both activities were associated with high molecular weight material, but at physiological pH and elevated ionic strength both activities behaved as much smaller entities of molecular weight between 25,000 and 30,000 daltons and it seems very likely that both activities are associated with the same molecule, i.e. PF4.

Confirmation of a Carboxylic Acid Metabolite of Polychlorotrifluoroethylene and a Method for Its GC-ECD Analysis in Biological Matrices

1992 ◽  
Vol 16 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Robert J. Greene ◽  
Wayne T. Brashear ◽  
Ken L. Auten ◽  
Deirdre A. Mahle
Keyword(s):  
Carboxylic Acid ◽  
Biological Matrices ◽  
Acid Metabolite

scholarly journals Simultaneous Measurement of 3-Chlorotyrosine and 3,5-Dichlorotyrosine in Whole Blood, Serum and Plasma by Isotope Dilution HPLC–MS-MS

2016 ◽  
Vol 40 (4) ◽  
pp. 264-271 ◽  
Author(s):  
Brian S. Crow ◽  
Jennifer Quiñones-González ◽  
Brooke G. Pantazides ◽  
Jonas W. Perez ◽  
W. Rucks Winkeljohn ◽  
...  
Keyword(s):  
Blood Serum ◽  
Isotope Dilution ◽  
Simultaneous Measurement ◽  
Whole Blood

Excretion of a Toxic Dose of Thallium

1990 ◽  
Vol 36 (8) ◽  
pp. 1506-1509 ◽  
Author(s):  
H A Chandler ◽  
G P R Archbold ◽  
J M Gibson ◽  
P O'Callaghan ◽  
J N Marks ◽  
...  
Keyword(s):  
Blood Serum ◽  
Whole Blood ◽  
Assisted Ventilation ◽  
Toxic Dose ◽  
Serum And Urine

Abstract We report a successfully treated case of severe thallium intoxication that required 95 days of assisted ventilation and 224 days of hospitalization. Monitoring of the patient for 500 days by measuring thallium in whole blood, serum, and urine is documented, and the role of the laboratory and utility of the measurements are considered.

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