Mycophenolic acid glucuronidation and its inhibition by non-steroidal anti-inflammatory drugs in human liver and kidney

2000 ◽  
Vol 56 (9-10) ◽  
pp. 659-664 ◽  
Author(s):  
M. Vietri ◽  
A. Pietrabissa ◽  
F. Mosca ◽  
G.M. Pacifici
Keyword(s):  
Mycophenolic Acid ◽  
Human Liver ◽  
Liver And Kidney ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

GLUCURONIDATION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: IDENTIFYING THE ENZYMES RESPONSIBLE IN HUMAN LIVER MICROSOMES

2005 ◽  
Vol 33 (7) ◽  
pp. 1027-1035 ◽  
Author(s):  
Gwendolyn E. Kuehl ◽  
Johanna W. Lampe ◽  
John D. Potter ◽  
Jeannette Bigler
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals COMPARING THE TOXIC EFFECTS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (CELECOXIB AND IBUPROFEN) ON HEART, LIVER, AND KIDNEY IN RATS

2018 ◽  
Vol 11 (6) ◽  
pp. 482 ◽  
Author(s):  
Noor D Aziz ◽  
Mazin H. Ouda ◽  
Moayad Mijbil Ubaid
Keyword(s):  
Serum Level ◽  
Toxic Effects ◽  
Total Serum ◽  
Control Group ◽  
Histological Alterations ◽  
Vascular Congestion ◽  
Liver And Kidney ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Ibuprofen Group

Objective: Nonsteroidal anti-inflammatory drugs (NSAIDs) do not reverse the disease progression, but they provide relief from pain and inflammation by inhibiting cyclooxygenase (COX) enzymes mediating the inflammatory pathway. Our aim was to make a meaningful comparison of both selective and non-selective COX-2 inhibitor to evaluate their toxic effects by measuring biochemical and histological alterations of heart, liver, and kidney.Methods: This study was conducted on 18 Sprague-Dawley rats of both sexes for 30 days, rats were divided into three groups (control group, ibuprofen group, and celecoxib group) each group included six rats.Results: The results are revealed that serum level of alanine aminotransferase, aspartate aminotransferase, alkaline phosphates, and total serum bilirubin was significantly increased (p<0.05) in ibuprofen and celecoxib group when compared with control, the highest level in celecoxib group, also serum level of urea was significantly elevated (p<0.05) in ibuprofen group when compared with control and celecoxib groups. Histopathological changes in cardiac tissue represented by vascular congestion and pericardial infiltration which are more prominent in celecoxib group, the changes in liver tissue revealed by vascular congestion and mild portal tract inflammation which is chronic in celecoxib group, while histological alterations in kidney tissue represented by severe vascular congestion with tubular necrosis which is more prominent in ibuprofen group.Conclusion: Both ibuprofen and celecoxib group have toxic effects on heart, liver, and kidney represented by the biochemical and histopathological findings.

scholarly journals GAMBARAN KARAKTERISTIK RESPONDEN RHEUMATOID ARTHRITIS PRE TREATMENT GINGER OIL (Zingiber Officinale Rosc) DAN TERAPI RESISTED ACTIVE MOVEMENT

2020 ◽  
Vol 3 (2) ◽  
pp. 337-343
Author(s):  
Muliyani Muliyani ◽  
◽  
Nazhipah Isnani ◽  
Enny Fauziah
Keyword(s):  
Rheumatoid Arthritis ◽  
Pharmacological Treatment ◽  
Zingiber Officinale ◽  
Active Movement ◽  
Natural Medicine ◽  
Liver And Kidney ◽  
History Of ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Pre Treatment

Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis in adults. Pharmacological treatment is quite effective to overcome it, but in some cases, especially in elderly RA sufferers, pharmacological treatment such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and DMARD (Disease Modifying Antirheumatic Drugs) have an impact on drug side effects, namely gastrointestinal disorders that cause toxic effects on liver and kidney. The developed natural medicine treatment has been supported by several previous studies that provide anti-inflammatory benefits, namely, ginger (Zingiber Officinale Rosc.). Ginger (Zingiber Officinale Rosc.) The method used is descriptive. The purpose of this study was to determine the characteristics of respondents who suffer from rheumathoid arthritic therapy with essential ginger oil and resisted active movement. The results of the study showed that as many as 20 respondents who suffered from rheumatoid arthritis, based on their characteristics, the most were female, namely 16 people (80%, ages 60-75 years, as many as 15 people (75%), the most part of the joints experiencing rheumathoid arthritis. occurred in the knee as many as 9 people (45%), work history, at most not working as many as 8 people (40%), history of injury, there were most injuries as many as 12 people (60%)

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