Bone Response to In Vivo Mechanical Loading in Two Breeds of Mice

1998 ◽  
Vol 63 (5) ◽  
pp. 442-449 ◽  
Author(s):  
M. P. Akhter ◽  
D. M. Cullen ◽  
E. A. Pedersen ◽  
D. B. Kimmel ◽  
R. R. Recker
Keyword(s):  
Mechanical Loading ◽  
Bone Response

scholarly journals No effect of verapamil on the local bone response to in vivo mechanical loading

2001 ◽  
Vol 19 (2) ◽  
pp. 328-336 ◽  
Author(s):  
Eva Samnegård ◽  
Diane M. Cullen ◽  
Mohammed P. Akhter ◽  
Donald B. Kimmel
Keyword(s):  
Mechanical Loading ◽  
Local Bone ◽  
Bone Response

Bone Response to In Vivo Mechanical Loading in C3H/HeJ Mice

1999 ◽  
Vol 65 (1) ◽  
pp. 41-46 ◽  
Author(s):  
E. A. Pedersen ◽  
M. P. Akhter ◽  
D. M. Cullen ◽  
D. B. Kimmel ◽  
R. R. Recker
Keyword(s):  
Mechanical Loading ◽  
Bone Response

Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains

2005 ◽  
Vol 99 (5) ◽  
pp. 1951-1957 ◽  
Author(s):  
Chandrasekhar Kesavan ◽  
Subburaman Mohan ◽  
Susanna Oberholtzer ◽  
Jon E. Wergedal ◽  
David J. Baylink
Keyword(s):  
Gene Expression ◽  
Mechanical Loading ◽  
Quantitative Computed Tomography ◽  
Age Groups ◽  
Marker Genes ◽  
Type I ◽  
Mineral Density ◽  
Anabolic Response ◽  
Bone Response ◽  
C3h Mice

Our goal is to evaluate skeletal anabolic response to mechanical loading in different age groups of C57B1/6J (B6) and C3H/HeJ (C3H) mice with variable loads using bone size, bone mineral density (BMD), and gene expression changes as end points. Loads of 6–9 N were applied at 2 Hz for 36 cycles for 12 days on the tibia of 10-wk-old female B6 and C3H mice. Effects of a 9-N load on 10-, 16-, and 36-wk-old C3H mice were also studied. Changes in bone parameters were measured using peripheral quantitative computed tomography, and gene expression was determined by real-time PCR. Total volumetric BMD was increased by 5 and 15%, respectively, with 8- and 9-N loads in the B6, but not the C3H, mice. Increases of 20 and 12% in periosteal circumference were reflected by dramatic 44 and 26% increases in total area in B6 and C3H mice, respectively. The bone response to bending showed no difference in the three age groups of B6 and C3H mice. At 2 days, mechanical loading resulted in significant downregulation in expression of bone resorption (BR), but not bone formation (BF) marker genes. At 4 and 8 days of loading, expression of BF marker genes (type I collagen, alkaline phosphatase, osteocalcin, and bone sialoprotein) was increased two- to threefold and expression of BR marker genes (matrix metalloproteinase-9 and thrombin receptor-activating peptide) was decreased two- to fivefold. Although expression of BF marker genes was upregulated four- to eightfold at 12 days of training, expression of BR marker genes was upregulated seven- to ninefold. Four-point bending caused significantly greater changes in expression of BF and BR marker genes in bones of the B6 than the C3H mice. We conclude that mechanical loading-induced molecular pathways are activated to a greater extent in the B6 than in the C3H mice, resulting in a higher anabolic response in the B6 mice.

Identifying the Early Effects of Mechanical Loading on the Lumbar Spine Using a Novel In Vivo Animal Model

2010 ◽  
Vol 10 (9) ◽  
pp. S75-S76
Author(s):  
Glenn P. Sanders ◽  
Sarah E. Linley ◽  
Elizabeth Brule ◽  
Scott McCallum ◽  
Eric W. Vandeventer ◽  
...  
Keyword(s):  
Animal Model ◽  
Lumbar Spine ◽  
Mechanical Loading ◽  
In Vivo Animal Model ◽  
Early Effects

In Vivo Models of Mechanical Loading

2019 ◽  
pp. 369-390 ◽  
Author(s):  
Behzad Javaheri ◽  
Nathalie Bravenboer ◽  
Astrid D. Bakker ◽  
Albert van der Veen ◽  
Roberto Lopes de Souza ◽  
...  
Keyword(s):  
Mechanical Loading ◽  
In Vivo Models

Structural changes in rat bone subjected to long-term, in vivo mechanical loading

Bone ◽  
1992 ◽  
Vol 13 (6) ◽  
pp. 417-422 ◽  
Author(s):  
C.H. Turner ◽  
T.A. Woltman ◽  
D.A. Belongia
Keyword(s):  
Mechanical Loading ◽  
Structural Changes ◽  
Rat Bone
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