Administration of a Glucocorticoid With Depot Effect Counteracts the Stimulating Effect of Growth Hormone on Cancellous and Cortical Bone of the Vertebral Body in Rats

1998 ◽  
Vol 63 (1) ◽  
pp. 14-21 ◽  
Author(s):  
G. Ørtoft ◽  
H. Oxlund ◽  
T. T. Andreassen
Keyword(s):  
Growth Hormone ◽  
Cortical Bone ◽  
Vertebral Body ◽  
Depot Effect

The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats

2009 ◽  
Vol 11 (8) ◽  
pp. 1094-1102 ◽  
Author(s):  
Troels T. Andreassen ◽  
Flemming Melsen ◽  
Hans Oxlund
Keyword(s):  
Growth Hormone ◽  
Cortical Bone ◽  
Vertebral Body ◽  
Aged Rats

Depth of vertebral screw insertion using a cortical bone trajectory technique in lumbar spinal fusion: radiological significance of a long cortical bone trajectory

2021 ◽  
pp. 1-6
Author(s):  
Keitaro Matsukawa ◽  
Yoshihide Yanai ◽  
Kanehiro Fujiyoshi ◽  
Takashi Kato ◽  
Yoshiyuki Yato
Keyword(s):  
Cortical Bone ◽  
Vertebral Body ◽  
Screw Loosening ◽  
Lumbar Spinal Fusion ◽  
Insertion Depth ◽  
Cortical Bone Trajectory ◽  
Screw Insertion ◽  
Bone Fusion ◽  
Screw Length ◽  
Lumbar Spinal

OBJECTIVE Contrary to original cortical bone trajectory (CBT), “long CBT” directed more anteriorly in the vertebral body has recently been recommended because of improved screw fixation and load sharing within the vertebra. However, to the authors’ knowledge there has been no report on the clinical significance of the screw length and screw insertion depth used with the long CBT technique. The aim of the present study was to investigate the influence of the screw insertion depth in the vertebra on lumbar spinal fusion using the CBT technique. METHODS A total of 101 consecutive patients with L4 degenerative spondylolisthesis who underwent single-level posterior lumbar interbody fusion at L4–5 using the CBT technique were included (mean follow-up 32.9 months). Screw loosening and bone fusion were radiologically assessed to clarify the factors contributing to these outcomes. Investigated factors were as follows: 1) age, 2) sex, 3) body mass index, 4) bone mineral density, 5) intervertebral mobility, 6) screw diameter, 7) screw length, 8) depth of the screw in the vertebral body (%depth), 9) facetectomy, 10) crosslink connector, and 11) cage material. RESULTS The incidence of screw loosening was 3.1% and bone fusion was achieved in 91.7% of patients. There was no significant factor affecting screw loosening. The %depth in the group with bone fusion [fusion (+)] was significantly higher than that in the group without bone fusion [fusion (−)] (50.3% ± 8.2% vs 37.0% ± 9.5%, respectively; p = 0.001), and multivariate logistic regression analysis revealed that %depth was a significant independent predictor of bone fusion. Receiver operating characteristic curve analysis identified %depth > 39.2% as a predictor of bone fusion (sensitivity 90.9%, specificity 75.0%). CONCLUSIONS This study is, to the authors’ knowledge, the first to investigate the significance of the screw insertion depth using the CBT technique. The cutoff value of the screw insertion depth in the vertebral body for achieving bone fusion was 39.2%.

Cortical bone ingrowth in growth hormone-loaded grooved implants with calcium phosphate coatings in goat femurs

Biomaterials ◽  
1998 ◽  
Vol 19 (1-3) ◽  
pp. 263-270 ◽  
Author(s):  
E.J. Blom ◽  
J.G.C. Verheij ◽  
J.M.A. de Blieck-Hogervorst ◽  
L. Di Silvio ◽  
C.P.A.T. Klein
Keyword(s):  
Growth Hormone ◽  
Calcium Phosphate ◽  
Cortical Bone ◽  
Bone Ingrowth ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings

Growth hormone is not able to counteract osteopenia of rat cortical bone induced by Glucocorticoid with protracted effect

Bone ◽  
1995 ◽  
Vol 17 (6) ◽  
pp. 543-548 ◽  
Author(s):  
G. Ørtoft ◽  
A. Brüel ◽  
T.T. Andreassen ◽  
H. Oxlund
Keyword(s):  
Growth Hormone ◽  
Cortical Bone

scholarly journals Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency?

2009 ◽  
Vol 296 (1) ◽  
pp. E147-E156 ◽  
Author(s):  
A. E. Stevenson ◽  
B. A. J. Evans ◽  
E. F. Gevers ◽  
C. Elford ◽  
R. W. J. McLeod ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cortical Bone ◽  
Gh Deficiency ◽  
Monosodium Glutamate ◽  
Residual Activity ◽  
Hormone Deficiency ◽  
Rodent Models ◽  
Femoral Strength ◽  
Igf I ◽  
Geometric Variables

Growth hormone (GH)-deficiency is usually associated with elevated adiposity, hyperleptinemia, and increased fracture risk. Since leptin is thought to enhance cortical bone formation, we have investigated the contribution of elevated adiposity and hyperleptinemia on femoral strength in rodent models of GH deficiency. Quantification of the transpubertal development of femoral strength in the moderately GH-deficient/hyperleptinemic Tgr rat and the profoundly GH-deficient/hypoleptinemic dw/dw rat revealed that the mechanical properties of cortical bone in these two models were similarly compromised, a 25–30% reduction in failure load being entirely due to impairment of geometric variables. In contrast, murine models of partial (GH antagonist transgenic) and complete (GH receptor-null) loss of GH signaling and elevated adiposity showed an impairment of femoral cortical strength proportionate to the reduction of GH signaling. To determine whether impaired femoral strength is exacerbated by obesity/hyperleptinemia, femoral strength was assessed in dw/dw rats following two developmental manipulations that elevate abdominal adiposity and circulating leptin, neonatal monosodium glutamate (MSG) treatment, and maintenance on an elevated fat diet. The additional impairment of femoral strength following MSG treatment is likely to have resulted from a reduction in residual activity of the hypothalamo-pituitary-GH-IGF-I axis, but consumption of elevated dietary fat, which did not reduce circulating IGF-I, failed to exacerbate the compromised femoral strength in dw/dw rats. Taken together, our data indicate that the obesity and hyperleptinemia usually associated with GH deficiency do not exert a significant influence over the strength of cortical bone.

No effect of growth hormone on recovery of load-protected bone Cortical bone mass and strength studied in rabbits

1988 ◽  
Vol 59 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Peter Laftman ◽  
Teddy Holmström ◽  
Anna-Lilsa Kairento ◽  
Olle S. Nilsson ◽  
Fridflnnur Sigurdsson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Bone Mass ◽  
Cortical Bone ◽  
Cortical Bone Mass
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