Ionotropic glutamate receptor-mediated responses in the rat primary somatosensory cortex evoked by noxious and innocuous cutaneous stimulation in vivo

2000 ◽  
Vol 131 (3) ◽  
pp. 282-292 ◽  
Author(s):  
M. Pollard
Keyword(s):  
Somatosensory Cortex ◽  
Glutamate Receptor ◽  
Primary Somatosensory Cortex ◽  
Ionotropic Glutamate Receptor ◽  
Cutaneous Stimulation

scholarly journals Cutaneous stimulation of the digits and lips evokes responses with different adaptation patterns in primary somatosensory cortex

NeuroImage ◽  
2010 ◽  
Vol 52 (4) ◽  
pp. 1477-1486 ◽  
Author(s):  
Mihai Popescu ◽  
Steven Barlow ◽  
Elena-Anda Popescu ◽  
Meredith E. Estep ◽  
Lalit Venkatesan ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Primary Somatosensory Cortex ◽  
Cutaneous Stimulation ◽  
Stimulation Of

scholarly journals High-order thalamic inputs to primary somatosensory cortex are stronger and longer lasting than cortical inputs

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Wanying Zhang ◽  
Randy M Bruno
Keyword(s):  
Somatosensory Cortex ◽  
Primary Motor Cortex ◽  
Pyramidal Neurons ◽  
Sensory Stimulation ◽  
Primary Somatosensory Cortex ◽  
Specific Substrate ◽  
Medial Nucleus ◽  
Posterior Medial Nucleus ◽  
Cortical Inputs

Layer (L) 2/3 pyramidal neurons in the primary somatosensory cortex (S1) are sparsely active, spontaneously and during sensory stimulation. Long-range inputs from higher areas may gate L2/3 activity. We investigated their in vivo impact by expressing channelrhodopsin in three main sources of feedback to rat S1: primary motor cortex, secondary somatosensory cortex, and secondary somatosensory thalamic nucleus (the posterior medial nucleus, POm). Inputs from cortical areas were relatively weak. POm, however, more robustly depolarized L2/3 cells and, when paired with peripheral stimulation, evoked action potentials. POm triggered not only a stronger fast-onset depolarization but also a delayed all-or-none persistent depolarization, lasting up to 1 s and exhibiting alpha/beta-range oscillations. Inactivating POm somata abolished persistent but not initial depolarization, indicating a recurrent circuit mechanism. We conclude that secondary thalamus can enhance L2/3 responsiveness over long periods. Such timescales could provide a potential modality-specific substrate for attention, working memory, and plasticity.

In vivo patch clamp analysis of synaptic responses evoked in primary somatosensory cortex in inflamed rats

2007 ◽  
Vol 58 ◽  
pp. S158
Author(s):  
Kohei Koga ◽  
Hiroaki Shiokawa ◽  
Masaharu Mizuno ◽  
Atsushi Doi ◽  
Hiroko Takase-Mizuguchi ◽  
...  
Keyword(s):  
Patch Clamp ◽  
Somatosensory Cortex ◽  
Primary Somatosensory Cortex ◽  
Synaptic Responses

In vivo two-photon calcium imaging of neuronal activities in primary somatosensory cortex in inflammatory chronic pain

2009 ◽  
Vol 65 ◽  
pp. S179
Author(s):  
Kei Eto ◽  
Hiroaki Wake ◽  
Hitoshi Ishibashi ◽  
Mami Noda ◽  
Junichi Nabekura
Keyword(s):  
Chronic Pain ◽  
Somatosensory Cortex ◽  
Calcium Imaging ◽  
Primary Somatosensory Cortex ◽  
Two Photon

scholarly journals Menthyl esterification allows chiral resolution for synthesis of artificial glutamate analogs

2020 ◽  
Author(s):  
Kenji Morokuma ◽  
Shuntaro Tsukamoto ◽  
Kei Miyako ◽  
Ryuichi Sakai ◽  
Raku Irie ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Glutamate Receptor ◽  
Chiral Resolution ◽  
Ionotropic Glutamate Receptor ◽  
X Ray ◽  
X Ray Crystallography ◽  
Configurational Analysis ◽  
In Vivo Assay ◽  
Enantiospecific Synthesis

Herein we report enantiospecific synthesis of two artificial glutamate analogs designed based on IKM–159, an antagonist selective to AMPA-type ionotropic glutamate receptor. The synthesis features chiral resolution of the carboxylic acid intermediate by esterification with L–menthol, followed by configurational analysis by NMR, conformational calculation, and X–ray crystallography. Mice in vivo assay showed that (2R)–MC–27 with six-membered oxacycle is neuroactive, whereas the (2S)–counterpart is inactive. It was also found that the TKM–38 with eight-membered azacycle is neuronally inactive to suggest the possibility that the analog with a smaller five-membered azacycle may act as a potent agent.

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