Further insight into the task-dependent excitability of motor evoked potentials in first dorsal interosseous muscle in humans

2001 ◽  
Vol 140 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Yoshiteru Hasegawa ◽  
Tatsuya Kasai ◽  
Toshio Tsuji ◽  
Susumu Yahagi
Keyword(s):  
Evoked Potentials ◽  
Motor Evoked Potentials ◽  
First Dorsal Interosseous ◽  
First Dorsal Interosseous Muscle ◽  
Insight Into ◽  
Dorsal Interosseous Muscle

Decreased corticospinal excitability after subthreshold 1 Hz rTMS over lateral premotor cortex

Neurology ◽  
2001 ◽  
Vol 57 (3) ◽  
pp. 449-455 ◽  
Author(s):  
Willibald Gerschlager ◽  
Hartwig R. Siebner ◽  
John C. Rothwell
Keyword(s):  
Motor Cortex ◽  
Parietal Cortex ◽  
Motor Evoked Potentials ◽  
Premotor Cortex ◽  
Corticospinal Excitability ◽  
First Dorsal Interosseous ◽  
First Dorsal Interosseous Muscle ◽  
The Right ◽  
Hand Area ◽  
Dorsal Interosseous Muscle

Objective: To study whether trains of subthreshold 1 Hz repetitive transcranial magnetic stimulation (rTMS) over premotor, prefrontal, or parietal cortex can produce changes in excitability of motor cortex that outlast the application of the train.Background: Prolonged 1 Hz rTMS over the motor cortex can suppress the amplitude of motor-evoked potentials (MEP) for several minutes after the end of the train. Because TMS can produce effects not only at the site of stimulation but also at distant sites to which it projects, the authors asked whether prolonged stimulation of sites distant but connected to motor cortex can also lead to lasting changes in MEP.Methods: Eight subjects received 1500 magnetic stimuli given at 1 Hz over the left lateral frontal cortex, the left lateral premotor cortex, the hand area of the left motor cortex, and the left anterior parietal cortex on four separate days. Stimulus intensity was set at 90% active motor threshold. Corticospinal excitability was probed by measuring the amplitude of MEP evoked in the right first dorsal interosseous muscle by single suprathreshold stimuli over the left motor hand area before, during, and after the conditioning trains.Results: rTMS over the left premotor cortex suppressed the amplitude of MEP in the right first dorsal interosseous muscle. The effect was maximized (approximately 50% suppression) after 900 pulses and outlasted the full train of 1500 stimuli for at least 15 minutes. Conditioning rTMS over the other sites did not modify the size of MEP. A control experiment showed that left premotor cortex conditioning had no effect on MEP evoked in the left first dorsal interosseous muscle.Conclusions: Subthreshold 1 Hz rTMS of the left premotor cortex induces a short-lasting inhibition of corticospinal excitability in the hand area of the ipsilateral motor cortex. This may provide a model for studying the functional interaction between premotor and motor cortex in healthy subjects and patients with movement disorders.

scholarly journals Proactive modulation of long-interval intracortical inhibition during response inhibition

2016 ◽  
Vol 116 (2) ◽  
pp. 859-867 ◽  
Author(s):  
Matthew J. Cowie ◽  
Hayley J. MacDonald ◽  
John Cirillo ◽  
Winston D. Byblow
Keyword(s):  
Evoked Potentials ◽  
Response Inhibition ◽  
Primary Motor Cortex ◽  
Motor Evoked Potentials ◽  
Motor Evoked Potential ◽  
Intracortical Inhibition ◽  
Task Context ◽  
Stop Trial ◽  
First Dorsal Interosseous Muscle ◽  
Dorsal Interosseous Muscle

Daily activities often require sudden cancellation of preplanned movement, termed response inhibition. When only a subcomponent of a whole response must be suppressed (required here on Partial trials), the ensuing component is markedly delayed. The neural mechanisms underlying partial response inhibition remain unclear. We hypothesized that Partial trials would be associated with nonselective corticomotor suppression and that GABAB receptor-mediated inhibition within primary motor cortex might be responsible for the nonselective corticomotor suppression contributing to Partial trial response delays. Sixteen right-handed participants performed a bimanual anticipatory response inhibition task while single- and paired-pulse transcranial magnetic stimulation was delivered to elicit motor evoked potentials in the left first dorsal interosseous muscle. Lift times, amplitude of motor evoked potentials, and long-interval intracortical inhibition were examined across the different trial types (Go, Stop-Left, Stop-Right, Stop-Both). Go trials produced a tight distribution of lift times around the target, whereas those during Partial trials (Stop-Left and Stop-Right) were substantially delayed. The modulation of motor evoked potential amplitude during Stop-Right trials reflected anticipation, suppression, and subsequent reinitiation of movement. Importantly, suppression was present across all Stop trial types, indicative of a “default” nonselective inhibitory process. Compared with blocks containing only Go trials, inhibition increased when Stop trials were introduced but did not differ between trial types. The amount of inhibition was positively correlated with lift times during Stop-Right trials. Tonic levels of inhibition appear to be proactively modulated by task context and influence the speed at which unimanual responses occur after a nonselective “brake” is applied.

Restoration of the first dorsal interosseous muscle

2021 ◽  
Author(s):  
C. Jaloux ◽  
A. Mayoly ◽  
C. Philandrianos ◽  
E. Bougie ◽  
R. Legré
Keyword(s):  
First Dorsal Interosseous ◽  
First Dorsal Interosseous Muscle ◽  
Dorsal Interosseous Muscle
Sign in / Sign up

Export Citation Format

Share Document