Canal-otolith interactions in the squirrel monkey vestibulo-ocular reflex and the influence of fixation distance

1998 ◽  
Vol 118 (1) ◽  
pp. 115-125 ◽  
Author(s):  
Laura Telford ◽  
Scott H. Seidman ◽  
Gary D. Paige
Keyword(s):  
Squirrel Monkey ◽  
Ocular Reflex ◽  
Fixation Distance ◽  
Vestibulo Ocular Reflex

The three-dimensional vestibulo-ocular reflex evoked by high-acceleration rotations in the squirrel monkey

2004 ◽  
Vol 159 (4) ◽  
pp. 433-446 ◽  
Author(s):  
Americo A. Migliaccio ◽  
Michael C. Schubert ◽  
Patpong Jiradejvong ◽  
David M. Lasker ◽  
Richard A. Clendaniel ◽  
...  
Keyword(s):  
Squirrel Monkey ◽  
Three Dimensional ◽  
Ocular Reflex ◽  
High Acceleration ◽  
Vestibulo Ocular Reflex

Multiplicative Computation in the Vestibulo-Ocular Reflex (VOR)

2007 ◽  
Vol 97 (4) ◽  
pp. 2780-2789 ◽  
Author(s):  
Wu Zhou ◽  
Youguo Xu ◽  
Ivra Simpson ◽  
Yidao Cai
Keyword(s):  
Neural Mechanism ◽  
Eye Position ◽  
Neural Pathways ◽  
Basic Operation ◽  
Gain Modulation ◽  
Ocular Reflex ◽  
Sensorimotor Transformations ◽  
Fixation Distance ◽  
Vestibulo Ocular Reflex ◽  
Behaving Monkeys

Multiplicative computation is a basic operation that is crucial for neural information processing, but examples of multiplication by neural pathways that perform well-defined sensorimotor transformations are scarce. Here in behaving monkeys, we identified a multiplication of vestibular and eye position signals in the vestibulo-ocular reflex (VOR). Monkeys were trained to maintain fixation on visual targets at different horizontal locations and received brief unilateral acoustic clicks (1 ms, rarefaction, 85∼110 db NHL) that were delivered into one of their external ear canals. We found that both the click-evoked horizontal eye movement responses and the click-evoked neuronal responses of the abducens neurons exhibited linear dependencies on horizontal conjugate eye position, indicating that the interaction of vestibular and horizontal conjugate eye position was multiplicative. Latency analysis further indicated that the site of the multiplication was within the direct VOR pathways. Based on these results, we propose a novel neural mechanism that implements the VOR gain modulation by fixation distance and gaze eccentricity. In this mechanism, the vestibular signal from a single labyrinth interacts multiplicatively with the position signals of each eye (Principle of Multiplication). These effects, however, interact additively with the other labyrinth (Principle of Addition). Our analysis suggests that the new mechanism can implement the VOR gain modulation by fixation distance and gaze eccentricity within the direct VOR pathways.

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