Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease

2020 ◽  
Author(s):  
Zihua Liu ◽  
Qiang Ye ◽  
Fang Wang ◽  
Yanan Guo ◽  
Rong Cui ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Dna Damage ◽  
Parkinson's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Thioredoxin Reductase ◽  
Thioredoxin Reductase 1

scholarly journals Parkinson's Disease, Genetic Factors and Endoplasmic Reticulum Stress: Systemic Review

2021 ◽  
Vol 10 (3) ◽  
pp. 343-357
Author(s):  
Asunur ADALI ◽  
Selinay Başak - ERDEMLİ-KÖSE ◽  
Anıl YİRÜN ◽  
Pınar ERKEKOĞLU
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Genetic Factors ◽  
Systemic Review

S-glutathionylation and endoplasmic reticulum stress in Parkinson's disease

2018 ◽  
Vol 120 ◽  
pp. S160
Author(s):  
Andreia Neves Carvalho ◽  
Carolina Pereira Tavares ◽  
Elsa Rodrigues ◽  
Margarida Castro-Caldas ◽  
Jack van Horssen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress

Endoplasmic reticulum stress, an important factor in the development of Parkinson’s disease

2020 ◽  
Vol 324 ◽  
pp. 20-29 ◽  
Author(s):  
Zheng Mou ◽  
Yu-he Yuan ◽  
Zhao Zhang ◽  
Lian-kun Song ◽  
Nai-Hong Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress

Reciprocal Upshot of Nitric Oxide, Endoplasmic Reticulum Stress, and Ubiquitin Proteasome System in Parkinson’s Disease Pathology

2020 ◽  
pp. 107385842094221
Author(s):  
Shubhangini Tiwari ◽  
Sarika Singh
Keyword(s):  
Nitric Oxide ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Neuronal Degeneration ◽  
Early Stage ◽  
Ubiquitin Proteasome System ◽  
Disease Etiology ◽  
Ubiquitin Proteasome

Parkinson’s disease (PD) pathology involves degeneration of nigrostriatal pathway, postulating symptoms associated with age, environment, and genetic anomalies, including nonlinear disease progression. Hallmark characteristics of PD include dopaminergic neuronal degeneration and death, which may also be exhibited by other neurological diseases, making the diagnosis of the disease intricate at early stage. Such obscure diagnosis of the disease, limited symptomatic improvements with available therapeutics, and their inability to modify the disease status instigate us to appraise the past research and formulate the colligating comprehensive insights. This review is accentuating on the role of nitric oxide, endoplasmic reticulum stress, and their association with the ubiquitin proteasome system (UPS) during PD pathology involving focus on ubiquitin ligases due to their regulatory functions. Meticulous understanding of these major disease-related pathological events and their functional alliance may render novel dimensions for better understanding of disease etiology, related mechanisms, as well as direction toward witnessing of new therapeutic targets for the management of Parkinson’s patients.

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