Determination of biogenic halogenated methyl-phenyl ethers (halogenated anisoles) in the picogram m -3 range in air

1996 ◽  
Vol 354 (3) ◽  
pp. 333-343
Author(s):  
Ursula F�hrer ◽  
Angela Dei�ler ◽  
K. Ballschmiter
Keyword(s):  
Phenyl Ethers ◽  
Methyl Phenyl

Determination of Free Phenol in Polyoxyethylene Phenyl Ethers

1955 ◽  
Vol 27 (11) ◽  
pp. 1836-1838 ◽  
Author(s):  
C. F. Smullin ◽  
F. P. Wetterau
Keyword(s):  
Free Phenol ◽  
Phenyl Ethers

Determination of electron inelastic mean free paths for poly[methyl(phenyl)silylene] films

Polymer ◽  
2009 ◽  
Vol 50 (11) ◽  
pp. 2445-2450 ◽  
Author(s):  
J. Zemek ◽  
J. Houdkova ◽  
P. Jiricek ◽  
A. Jablonski ◽  
V. Jurka ◽  
...  
Keyword(s):  
Methyl Phenyl

Methylation of Phenolic Hydroxyl Group and Demethylation of Anisoles

2009 ◽  
Vol 2009 (4) ◽  
pp. 229-230 ◽  
Author(s):  
Nobuhiro Sato ◽  
Hiroyuki Endo
Keyword(s):  
Microwave Heating ◽  
Room Temperature ◽  
Reverse Reaction ◽  
Phenolic Hydroxyl ◽  
Hydroxyl Group ◽  
Hydroxyl Groups ◽  
Phenolic Hydroxyl Groups ◽  
Phenyl Ethers ◽  
Methyl Phenyl

A mild methylation of phenolic hydroxyl groups with iodomethane was enabled in the presence of sodium bis(trimethylsilyl)amide at room temperature. The reverse reaction, namely demethylation of methyl phenyl ethers, was easily achieved by microwave heating with neat iodotrimethylsilane.

scholarly journals Oxygen-Free Regioselective Biocatalytic Demethylation of Methyl-phenyl Ethers via Methyltransfer Employing Veratrol-O-demethylase

ACS Catalysis ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 10375-10380
Author(s):  
Christopher Grimm ◽  
Mattia Lazzarotto ◽  
Simona Pompei ◽  
Johanna Schichler ◽  
Nina Richter ◽  
...  
Keyword(s):  
Phenyl Ethers ◽  
Methyl Phenyl

scholarly journals Development and Validation of RP-Chiral HPLC Method for Determination of (R)-Enantiomer Excess Content in Efavirenz

2020 ◽  
Vol 32 (9) ◽  
pp. 2208-2212
Author(s):  
CH. RAMESH ◽  
DHARMASOTH RAMA DEVI DEVI ◽  
M.N.B. SRINIVAS ◽  
S. RADHA KRISHNA ◽  
NAGARAJU RAJANA ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Hplc Method ◽  
Chiral Hplc ◽  
Reverse Phase ◽  
Limit Of Quantification ◽  
Column Temperature ◽  
Enantiomer Excess ◽  
Development And Validation ◽  
Methyl Phenyl

simple, specific, linear, accurate and precise reverse phase chiral HPLC method was developed for the separation of efavirenz enantiomers by using the Lux Amylose-2 column containing amylose tris(5-chloro-2-methyl phenyl carbamate) as a stationary phase. The mobile phase consists of 0.1 % formic acid in water and acetonitrile (55:45, v/v). The flow rate was kept at 1.0 mL/min and the detection wavelength used 252 nm and the column temperature was set at 25 ºC. The limit of detection was 0.01 mg/mL and the limit of quantification was 0.04 mg/mL. The linearity calibration curve of (R)-enantiomer was shown well from the range of 0.04 mg/mL to 0.4 mg/mL. The values of the correlation coefficient were 0.999 and 0.999 for (R)-enantiomer and (S)-efavirenz, respectively. The percentage recoveries of (R)-enantiomer from efavirenz drug substance were ranged from 93.5% to 107.5%. The results demonstrated that developed RP-chiral HPLC method was simple, precise, robust and applicable for the estimation of (R)-enantiomer in efavirenz API. This method was validated in as per ICH Q2 (R1) and USP validation of compendial methods <1225>.

Sign in / Sign up

Export Citation Format

Share Document