Determination of total iron in ground waters and multivitamin tablets using a solid-phase reactor with tiron immobilised on amberlite ion-exchange resin in a flow injection system

1998 ◽  
Vol 362 (3) ◽  
pp. 319-323 ◽  
Author(s):  
J. F. van Staden ◽  
L. G. Kluever
Keyword(s):  
Ion Exchange ◽  
Flow Injection ◽  
Exchange Resin ◽  
Solid Phase ◽  
Ion Exchange Resin ◽  
Total Iron ◽  
Injection System ◽  
Solid Phase Reactor ◽  
Flow Injection System

scholarly journals DETERMINATION OF NITRAZEPAM IN PHARMACEUTICAL PREPARATIONS USING SOLID-PHASE REACTOR - REVERSE FLOW INJECTION ANALYSIS

2018 ◽  
Vol 11 (7) ◽  
pp. 487
Author(s):  
Mariam Jamal ◽  
Hind Hadi
Keyword(s):  
Flow Injection ◽  
Solid Phase ◽  
Reverse Flow ◽  
Injection System ◽  
Physical Parameters ◽  
Relative Standard ◽  
Solid Phase Reactor ◽  
Oxidation Reactor ◽  
Reverse Flow Injection

Objective: A simple and fast reverse flow injection system including a solid-phase reactor containing PbO2 with spectrophotometric detection was suggested for the determination of nitrazepam (NIT) in pharmaceutical tablets.Methods: The method was based on oxidation of the reagent (phloroglucinol) with PbO2 immobilized in a polymeric matrix which was then coupled with reduced NIT in aqueous medium. The pink-colored product was measured at 530 nm.Results: The calibration graph was linear over the range of 50–400 μg/mL with a relative standard deviation of <2% (n=29) and a sample throughput of 48 samples per hour. The variables of the solid-phase reactor such as composition, particle size, and length of the reactor were studied. The chemical and physical parameters, which affect the reverse flow method, were also studied.Conclusion: The oxidation reactor engaged with a flow system was successfully applied for the determination of NIT with good sensitivity and precision.

Liposome-based flow-injection immunoassay for determining theophylline in serum

1993 ◽  
Vol 39 (3) ◽  
pp. 386-391 ◽  
Author(s):  
L Locascio-Brown ◽  
A L Plant ◽  
R Chesler ◽  
M Kroll ◽  
M Ruddel ◽  
...  
Keyword(s):  
Flow Injection ◽  
Solid Phase ◽  
Injection System ◽  
Antibody Activity ◽  
Excellent Correlation ◽  
Serum Theophylline ◽  
Solid Phase Reactor ◽  
Sequential Samples ◽  
Flow Injection System ◽  
Comparison Of The Results

Abstract We developed a method for quantitatively determining theophylline in serum, using a heterogeneous immunoassay called flow-injection immunoanalysis. The reaction involves competition between serum theophylline and theophylline-labeled liposomes. Separation occurs on a solid-phase reactor column containing immobilized antibody to theophylline incorporated in a flow-injection system. Subsequent lysis of the bound liposomes provides sensitive detection of the analyte. Effective regeneration of the immobilized antibody activity allows the reactor to be reused for hundreds of sequential samples. Comparison of the results of the flow-injection immunoassay method with results obtained with a commercially available fluorescence polarization method showed an excellent correlation.

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