TUNA FISH (T-30) - A new proficiency testing material for the determination of As and Hg in seafood

1997 ◽  
Vol 358 (3) ◽  
pp. 441-445 ◽  
Author(s):  
B. Gawlik ◽  
Martine Druges ◽  
Michele Bianchi ◽  
Angelo Bortoli ◽  
Antonius Kettrup ◽  
...  
Keyword(s):  
Proficiency Testing ◽  
Testing Material ◽  
Tuna Fish ◽  
Proficiency Testing Material

Preparation of an infant formula proficiency testing material and assessment of its homogeneity and stability

2015 ◽  
Vol 20 (5) ◽  
pp. 373-380 ◽  
Author(s):  
A. Sorbo ◽  
M. Ciprotti ◽  
A. Colabucci ◽  
C. Zoani ◽  
M. Di Gregorio ◽  
...  
Keyword(s):  
Infant Formula ◽  
Proficiency Testing ◽  
Testing Material ◽  
Proficiency Testing Material

Comparison of Fresh Frozen Serum to Traditional Proficiency Testing Material in a College of American Pathologists Survey for Ferritin, Folate, and Vitamin B12

2005 ◽  
Vol 129 (3) ◽  
pp. 323-327
Author(s):  
Jay L. Bock ◽  
David B. Endres ◽  
Ronald J. Elin ◽  
Edward Wang ◽  
Bruce Rosenzweig ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Proficiency Testing ◽  
Matrix Effects ◽  
Testing Material ◽  
Design Data ◽  
Fresh Frozen ◽  
Survey Results ◽  
Artificial Nature ◽  
Folate And Vitamin B12 ◽  
Proficiency Testing Material

Abstract Context.—Comparison of different analytical methods in proficiency surveys may be affected by the artificial nature of the survey material. Objective.—To compare intermethod differences in proficiency survey results between 2 types of survey material, conventional proficiency testing material (PTM) and fresh frozen human serum (FFS), for 3 markers of anemia: ferritin, folate, and vitamin B12. Design.—Data were gathered from a 2003 survey event in the College of American Pathologists Ligand (“K”) Series, in which the specimens to be tested by each participating laboratory included 1 vial of FFS and 2 vials of PTM with different analyte concentrations. The more than 1600 laboratories subscribing to the survey were not advised as to the nature of the specimens. Main Outcome Measures.—The bias of each method relative to the median of method means for each analyte and each type of survey material, and the interlaboratory coefficient of variation for each method. Results.—For each of the 3 analytes, moderate to large method biases were observed. For ferritin, method biases correlated strongly between comparable PTM and FFS specimens (Spearman r = 0.863, P < .001), whereas virtually no correlation was found for folate (r = −0.224, P = .48), and a marginally significant correlation existed for B12 (r = 0.55, P = .049). Conclusions.—With ferritin, proficiency survey performance of PTM is similar to that of FFS, implying that method biases relate mainly to calibration. With folate and to a lesser extent with B12, PTM and FFS exhibit different method biases, implying that the biases reflect analyte heterogeneity and/or matrix effects.

Commutability of proficiency testing material containing amitriptyline and nortriptyline: A study within the framework of the Dutch Calibration 2.000 project

2019 ◽  
Vol 498 ◽  
pp. 6-10
Author(s):  
Karen Robijns ◽  
Niels W. Boone ◽  
Rob T.P. Jansen ◽  
Aldy W.H.M. Kuypers ◽  
Cees Neef ◽  
...  
Keyword(s):  
Proficiency Testing ◽  
Testing Material ◽  
Proficiency Testing Material

Commutability of proficiency testing material containing tobramycin: a study within the framework of the Dutch Calibration 2.000 project

2017 ◽  
Vol 55 (2) ◽  
Author(s):  
Karen Robijns ◽  
Niels W. Boone ◽  
Rob T.P. Jansen ◽  
Aldy W.H.M. Kuypers ◽  
Cees Neef ◽  
...  
Keyword(s):  
Human Serum ◽  
Proficiency Testing ◽  
External Quality Assessment ◽  
Regression Line ◽  
Measurement Methods ◽  
Testing Material ◽  
External Quality ◽  
Decision Limit ◽  
High Concentrations ◽  
Proficiency Testing Material

AbstractBackground:Results from external quality assessment schemes (EQASs) can provide information about accuracy and comparability of different measurement methods, provided that the material used in these schemes behave identical to patient samples among the different methods, a characteristic also known as commutability. The aim of this study was to assess the commutability of different matrices for the material used in an EQAS for tobramycin.Methods:Proficiency testing material (PTM) and patient samples containing tobramycin were prepared, collected, pooled, and distributed to participating laboratories for analysis. Low, medium, and high tobramycin concentrations in liquid human, liquid bovine and lyophilized bovine serum were tested in this study. The patient serum results of every laboratory were plotted against each of the other laboratories, and the distances of the PTM results to the patient serum regression line were calculated. For comparison, these distances were divided by the average within-laboratory standard deviation (SDResults:With 10 laboratories participating in this study, 45 laboratory couples were formed. For human serum, only one relative residual for high concentrations of tobramycin was found outside the commutability decision limit. For liquid and lyophilized bovine sera, the number of relative residuals outside the decision limit was between 15 and 18 for low, medium, and high tobramycin concentrations.Conclusions:The PTM used for tobramycin is preferably prepared with human serum.

A Comparison of Human Chorionic Gonadotropin– Related Components in Fresh Frozen Serum With the Proficiency Testing Material Used by the College of American Pathologists

2005 ◽  
Vol 129 (3) ◽  
pp. 328-330
Author(s):  
George J. Knight ◽  
Glenn E. Palomaki ◽  
George G. Klee ◽  
William E. Schreiber ◽  
Lawrence A. Cole
Keyword(s):  
Proficiency Testing ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Peer Group ◽  
Fold Increase ◽  
Reference Laboratory ◽  
Testing Material ◽  
Test Kit ◽  
Fresh Frozen ◽  
Proficiency Testing Material

Abstract Context.—As part of a College of American Pathologists (CAP) proficiency testing survey, a comparison is made between human chorionic gonadotropin (hCG) results from an actual patient pool and a similarly targeted artificial sample. The goal is to gain insight into the possible source(s) of bias attributable to the proficiency testing material (PTM) with a view toward creating more appropriate survey materials. Objective.—To compare hCG and related variants in a pool of fresh frozen sera (FFS) with that found in PTM. Design.—The 2003 CAP K/KN-A Survey included a FFS specimen along with admixtures of PTM. The FFS (K-02) and 1 PTM admixture (K-01) had similar mean hCG values. Five hCG-related analytes were measured on these 2 samples by a reference laboratory. Participants.—Approximately 1800 clinical laboratories and diagnostic test kit manufacturers participated in the K/ KN-A Survey. Main Outcome Measures.—Method imprecision (coefficient of variation) and method bias (relative difference between peer group mean and all-method median) were computed for the 2 samples. Differences were evaluated with respect to hCG-related analytes levels. Results.—All-method hCG results were 12.9 mIU/mL (12.9 IU/L) for the PTM material and 21.6 mIU/mL (21.6 IU/L) for the FFS material. Method biases for 14 manufacturers were greater for PTM than for FFS (−40% to +35% and −16% to +23%). Twelve of 14 methods had higher coefficients of variation on PTM. Total hCG and free β hCG measurements by the reference laboratory were 14.1 mIU/ mL (14.1 IU/L) for the PTM material and 18.5 mIU/mL (18.5 U/L) for the FFS material (FFS), and 2.4 (PTM) and 0.7 (FFS) mIU/mL (2.4 and 0.7 IU/L), respectively. On a molar basis, free β represented 17% and 4% of the total hCG, respectively. Levels of hyperglycosylated hCG, nicked hCG, and β core fragment were not measurable in either sample. Conclusions.—It is unlikely that the hCG added to the PTM is the source of the increased bias and variability. The main difference is a 3-fold increase in free β found in the PTM, but methods previously found to strongly react with free β were not systematically elevated. The biases between manufacturers found for the FFS specimen are likely attributable to calibration differences.

A Multilaboratory Commutability Evaluation of Proficiency Testing Material for Carbamazepine and Valproic Acid

2015 ◽  
Vol 37 (4) ◽  
pp. 445-450 ◽  
Author(s):  
Karen Robijns ◽  
Niels W. Boone ◽  
Aldy W. H. M. Kuypers ◽  
Rob T. P. Jansen ◽  
Cees Neef ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Proficiency Testing ◽  
Testing Material ◽  
Proficiency Testing Material

Determination of selected heavy metals in tuna fish (Thunnus thynnus)

2013 ◽  
Vol 38 (03) ◽  
Author(s):  
S Mol ◽  
S Karakulak ◽  
S Ulusoy
Keyword(s):  
Heavy Metals ◽  
Thunnus Thynnus ◽  
Tuna Fish

A Rapid Method for Determination of Buprenorphine and Norbuprenorphine in Urine by UPLC-MS/MS

2020 ◽  
Vol 16 ◽  
Author(s):  
Aykut Kul ◽  
Murat Ozdemir ◽  
Selma Ozilhan ◽  
Olcay Sagirli
Keyword(s):  
Forensic Science ◽  
Rapid Method ◽  
Proficiency Testing ◽  
Mass Spectrometer ◽  
Illicit Market ◽  
Analysis Methods ◽  
Accuracy And Precision ◽  
Lower Limits

Background: Buprenorphine is quite common in the illicit market. Buprenorphine-containing drugs abuse is frequently encountered in patients. The analysis methods used to determine the abuse of buprenorphine and norbuprenorphine are important for forensic science. Buprenorphine is metabolized to norbuprenorphine by the liver. Objective: Therefore, the determination of buprenorphine and norbuprenorphine in urine is one of the methods to determine the abuse of buprenorphine. Methods: In this study, we have developed a precise, simple, and rapid ultra-performance liquid chromatographytandem mass spectrometer method for the determination of buprenorphine and norbuprenorphine simultaneously. Results: The developed method was validated in terms of selectivity and linearity, which was in the range of 9–1800 ng/mL for both buprenorphine and norbuprenorphine. The intra-assay and inter-assay accuracy and precision were found within acceptable limits of the EMA guideline. Lower limits of quantitation were 9 ng/mL for both buprenorphine and norbuprenorphine. Conclusion: The developed method was successfully applied for the determination of both analytes in the proficiency testing samples.

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