Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: a comparison with the cholinesterase inhibitor E2020

1998 ◽  
Vol 135 (3) ◽  
pp. 242-255 ◽  
Author(s):  
G. Poorheidari ◽  
K. J. Stanhope ◽  
J. A. Pratt
Keyword(s):  
Potassium Channel ◽  
Cholinesterase Inhibitor ◽  
Channel Blockers ◽  
Delayed Matching ◽  
Potassium Channel Blockers ◽  
Position Task ◽  
Matching To Position

Proteinase inhibitor homologues as potassium channel blockers

1994 ◽  
Vol 1 (4) ◽  
pp. 246-250 ◽  
Author(s):  
Jean-Marc Lancelin ◽  
Marie-Françoise Foray ◽  
Marc Poncin ◽  
Michelle Hollecker ◽  
Dominique Marion
Keyword(s):  
Potassium Channel ◽  
Proteinase Inhibitor ◽  
Channel Blockers ◽  
Potassium Channel Blockers

scholarly journals Action Potentials in Rhodnius Oocytes: Repolarization is Sensitive to Potassium Channel Blockers

1986 ◽  
Vol 126 (1) ◽  
pp. 119-132
Author(s):  
M. J. O'DONNELL
Keyword(s):  
Potassium Channel ◽  
Action Potentials ◽  
Potassium Conductance ◽  
Channel Blockers ◽  
Calcium Dependent ◽  
Outward Rectification ◽  
Current Voltage ◽  
Potassium Channel Blockers ◽  
Potassium Conductances ◽  
Voltage Dependent

Depolarization of Rhodnius oocytes evokes action potentials (APs) whose rising phase is calcium-dependent. The ionic basis for the repolarizing (i.e. falling) phase of the AP was examined. Addition of potassium channel blockers (tetraethylammonium, tetrabutylammonium, 4-aminopyridine, atropine) to the bathing saline increased the duration and overshoot of APs. Intracellular injection of tetraethyl ammonium had similar effects. These results suggest that a voltage-dependent potassium conductance normally contributes to repolarization. Repolarization does not require a chloride influx, because substitution of impermeant anions for chloride did not increase AP duration. AP duration and overshoot actually decreased progressively when chloride levels were reduced. Current/voltage curves show inward and outward rectification, properties often associated with potassium conductances. Outward rectification was largely blocked by external tetraethylammonium. Possible functions of the rectifying properties of the oocyte membrane are discussed.

scholarly journals Sustained performance by common marmosets in a delayed matching to position task with variable stimulus presentations

2016 ◽  
Vol 297 ◽  
pp. 277-284 ◽  
Author(s):  
Yumiko Yamazaki ◽  
Masakado Saiki ◽  
Masayuki Inada ◽  
Shigeru Watanabe ◽  
Atsushi Iriki
Keyword(s):  
Variable Stimulus ◽  
Common Marmosets ◽  
Delayed Matching ◽  
Position Task ◽  
Sustained Performance ◽  
Matching To Position
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