Disruption of trace conditioning of the nictitating membrane response in rabbits by central cholinergic blockade

1997 ◽  
Vol 131 (2) ◽  
pp. 161-166 ◽  
Author(s):  
Tsugio Kaneko ◽  
R. F. Thompson
Keyword(s):  
Trace Conditioning ◽  
Nictitating Membrane ◽  
Cholinergic Blockade ◽  
Nictitating Membrane Response

scholarly journals Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Bernard G. Schreurs ◽  
Desheng Wang ◽  
Carrie A. Smith-Bell ◽  
Lauren B. Burhans ◽  
Roger Bell ◽  
...  
Keyword(s):  
Dietary Cholesterol ◽  
Trace Conditioning ◽  
Cholesterol Concentration ◽  
Long Term Memory ◽  
Cholesterol Diet ◽  
Nictitating Membrane ◽  
Term Memory ◽  
Cholesterol Levels ◽  
Nictitating Membrane Response

A rabbit model of Alzheimer’s disease based on feeding a cholesterol diet for eight weeks shows sixteen hallmarks of the disease, including learning and memory changes. Although we have shown 2% cholesterol and copper in water can retard learning, other studies show feeding dietary cholesterol before learning can improve acquisition whereas feeding cholesterol after learning can degrade long-term memory. We explored this issue by manipulating cholesterol concentration and duration following classical trace conditioning of the rabbit’s nictitating membrane response and assessed conditioned responding after eight weeks on cholesterol. First, rabbits given trace classical conditioning followed by 0.5%, 1%, or 2% cholesterol for eight weeks showed body weight and serum cholesterol levels that were a function of dietary cholesterol. Although all concentrations of cholesterol showed some sign of retarding long-term memory, the level of memory retardation was correlated with serum cholesterol levels. Second, rabbits given trace conditioning followed by different durations of a 2% cholesterol diet combined with different durations of a 0% control diet for 8 weeks showed duration and timing of a 2% cholesterol diet were important in affecting recall. The data support the idea that dietary cholesterol may retard long-term memory.

Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response.

1986 ◽  
Vol 100 (5) ◽  
pp. 729-744 ◽  
Author(s):  
Paul R Solomon ◽  
Ellen R. Vander Schaaf ◽  
Richard F. Thompson ◽  
Donald J. Weisz
Keyword(s):  
Trace Conditioning ◽  
Nictitating Membrane ◽  
Nictitating Membrane Response ◽  
Classically Conditioned

Trace conditioning of the nictitating membrane response in decorticate rabbits

1984 ◽  
Vol 11 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Christopher H. Yeo ◽  
Mervyn J. Hardiman ◽  
John W. Moore ◽  
I.Steele Russell
Keyword(s):  
Trace Conditioning ◽  
Nictitating Membrane ◽  
Nictitating Membrane Response
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