Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature

2021 ◽  
Author(s):  
Hannah Thomson ◽  
Izelle Labuschagne ◽  
Lisa-Marie Greenwood ◽  
Emily Robinson ◽  
Hannah Sehl ◽  
...  
Keyword(s):  
Systematic Review ◽  
Functional Connectivity ◽  
Resting State ◽  
Review Of The Literature ◽  
Resting State Functional Connectivity

scholarly journals Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review

2018 ◽  
Vol 43 (5) ◽  
pp. 298-316 ◽  
Author(s):  
Sabrina K. Syan ◽  
Mara Smith ◽  
Benicio N. Frey ◽  
Raheem Remtulla ◽  
Flavio Kapczinski ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Clinical Remission ◽  
Resting State Functional Connectivity

scholarly journals The Effect of Transcranial Direct Current Stimulation in Changing Resting-State Functional Connectivity in Patients With Neurological Disorders: A Systematic Review

2020 ◽  
Vol 12 ◽  
pp. 117957352097683
Author(s):  
Melody MY Chan ◽  
Yvonne MY Han
Keyword(s):  
Systematic Review ◽  
Functional Connectivity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Resting State ◽  
Neurological Disorders ◽  
Analytical Methods ◽  
Brain Regions ◽  
Resting State Functional Connectivity ◽  
Stimulation Intensity

Background: People with neurological disorders are found to have abnormal resting-state functional connectivity (rsFC), which is associated with the persistent functional impairment found in these patients. Recently, transcranial direct current stimulation (tDCS) has been shown to improve rsFC, although the results are inconsistent. Objective: We hope to explore whether tDCS induces rsFC changes among patients with neurological disorders, whether rsFC is clinically relevant and how different tDCS parameters affect rsFC outcome among these individuals. Methods: A systematic review was conducted according to PRISMA guidelines (systematic review registration number: CRD42020168654). Randomized controlled trials that studied the tDCS effects on rsFC between the experimental and sham-controlled groups using either electrophysiological or neuroimaging methods were included. Results: Active tDCS can induce changes in both localized (ie, brain regions under the transcranial electrodes) and diffused (ie, brain regions not directly influenced by the transcranial electrodes) rsFC. Interestingly, fMRI studies showed that the default mode network was enhanced regardless of patients’ diagnoses, the stimulation paradigms used or the rsFC analytical methods employed. Second, stimulation intensity, but not total stimulation time, appeared to positively influence the effect of tDCS on rsFC. Limitations and conclusion: Due to the inherent heterogeneity in rsFC analytical methods and tDCS protocols, meta-analysis was not conducted. We recommend that future studies may investigate the effect of tDCS on rsFC for repeated cathodal stimulation. For clinicians, we suggest anodal stimulation at a higher stimulation intensity within the safety limit may maximize tDCS effects in modulating aberrant functional connectivity of patients with neurological disorders.

scholarly journals Resting State Functional Connectivity of Brain With Electroconvulsive Therapy in Depression: Meta-Analysis to Understand Its Mechanisms

2021 ◽  
Vol 14 ◽  
Author(s):  
Preeti Sinha ◽  
Himanshu Joshi ◽  
Dhruva Ithal
Keyword(s):  
Systematic Review ◽  
Functional Connectivity ◽  
Electroconvulsive Therapy ◽  
Resting State ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Cingulate Cortex ◽  
Activation Likelihood Estimation ◽  
Resting State Functional Connectivity ◽  
The Right

Introduction: Electroconvulsive therapy (ECT) is a commonly used brain stimulation treatment for treatment-resistant or severe depression. This study was planned to find the effects of ECT on brain connectivity by conducting a systematic review and coordinate-based meta-analysis of the studies performing resting state fMRI (rsfMRI) in patients with depression receiving ECT.Methods: We systematically searched the databases published up to July 31, 2020, for studies in patients having depression that compared resting-state functional connectivity (rsFC) before and after a course of pulse wave ECT. Meta-analysis was performed using the activation likelihood estimation method after extracting details about coordinates, voxel size, and method for correction of multiple comparisons corresponding to the significant clusters and the respective rsFC analysis measure with its method of extraction.Results: Among 41 articles selected for full-text review, 31 articles were included in the systematic review. Among them, 13 articles were included in the meta-analysis, and a total of 73 foci of 21 experiments were examined using activation likelihood estimation in 10 sets. Using the cluster-level interference method, one voxel-wise analysis with the measure of amplitude of low frequency fluctuations and one seed-voxel analysis with the right hippocampus showed a significant reduction (p < 0.0001) in the left cingulate gyrus (dorsal anterior cingulate cortex) and a significant increase (p < 0.0001) in the right hippocampus with the right parahippocampal gyrus, respectively. Another analysis with the studies implementing network-wise (posterior default mode network: dorsomedial prefrontal cortex) resting state functional connectivity showed a significant increase (p < 0.001) in bilateral posterior cingulate cortex. There was considerable variability as well as a few key deficits in the preprocessing and analysis of the neuroimages and the reporting of results in the included studies. Due to lesser studies, we could not do further analysis to address the neuroimaging variability and subject-related differences.Conclusion: The brain regions noted in this meta-analysis are reasonably specific and distinguished, and they had significant changes in resting state functional connectivity after a course of ECT for depression. More studies with better neuroimaging standards should be conducted in the future to confirm these results in different subgroups of depression and with varied aspects of ECT.

Dysregulated resting state functional connectivity and obesity: a systematic review

2021 ◽  
Author(s):  
Sabrina K. Syan ◽  
Carly McIntyre-Wood ◽  
Luciano Minuzzi ◽  
Geoffrey Hall ◽  
Randi E. McCabe ◽  
...  
Keyword(s):  
Systematic Review ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity

Resting-state functional connectivity in the idiopathic generalized epilepsies: A systematic review and meta-analysis of EEG and MEG studies

2021 ◽  
Vol 124 ◽  
pp. 108336
Author(s):  
Anita L. Dharan ◽  
Stephen C. Bowden ◽  
Alan Lai ◽  
Andre D.H. Peterson ◽  
Mike W.-L. Cheung ◽  
...  
Keyword(s):  
Systematic Review ◽  
Functional Connectivity ◽  
Resting State ◽  
Meta Analysis ◽  
Resting State Functional Connectivity
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