Protective effects of tetramethylpyrazine on dysfunction of the locus coeruleus in rats exposed to single prolonged stress by anti-ER stress mechanism

2021 ◽  
Author(s):  
Yun Hou ◽  
Meifeng Li ◽  
Yinchuan Jin ◽  
Feibo Xu ◽  
Shaohua Liang ◽  
...  
Keyword(s):  
Er Stress ◽  
Locus Coeruleus ◽  
Protective Effects ◽  
Single Prolonged Stress ◽  
Prolonged Stress

scholarly journals Altered locus coeruleus-norepinephrine function following single prolonged stress

2012 ◽  
Vol 37 (6) ◽  
pp. 901-909 ◽  
Author(s):  
Sophie A. George ◽  
Dayan Knox ◽  
Andre L. Curtis ◽  
J. Wayne Aldridge ◽  
Rita J. Valentino ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Single Prolonged Stress ◽  
Prolonged Stress

scholarly journals Locus coeruleus response to single-prolonged stress and early intervention with intranasal neuropeptide Y

2015 ◽  
Vol 135 (5) ◽  
pp. 975-986 ◽  
Author(s):  
Esther L. Sabban ◽  
Marcela Laukova ◽  
Lishay G. Alaluf ◽  
Emelie Olsson ◽  
Lidia I. Serova
Keyword(s):  
Early Intervention ◽  
Neuropeptide Y ◽  
Locus Coeruleus ◽  
Single Prolonged Stress ◽  
Prolonged Stress

scholarly journals Effects of RU486 treatment after single prolonged stress depend on the post-stress interval

2020 ◽  
Vol 108 ◽  
pp. 103541
Author(s):  
Jinlan Ding ◽  
Xinzhao Chen ◽  
Marcia Santos da Silva ◽  
Jolanthe Lingeman ◽  
Fang Han ◽  
...  
Keyword(s):  
Single Prolonged Stress ◽  
Prolonged Stress ◽  
Post Stress

scholarly journals 5-ALA Attenuates the Palmitic Acid-Induced ER Stress and Apoptosis in Bovine Mammary Epithelial Cells

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1183
Author(s):  
Mst Mamuna Sharmin ◽  
Md Aminul Islam ◽  
Itsuki Yamamoto ◽  
Shin Taniguchi ◽  
Shinichi Yonekura
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Palmitic Acid ◽  
Er Stress ◽  
Aminolevulinic Acid ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Protective Effects ◽  
Bovine Mammary Epithelial Cells ◽  
Induced Apoptosis

The conservation of mammary gland physiology by maintaining the maximum number of mammary epithelial cells (MECs) is of the utmost importance for the optimum amount of milk production. In a state of negative energy balance, palmitic acid (PA) reduces the number of bovine MECs. However, there is no effective strategy against PA-induced apoptosis of MECs. In the present study, 5-aminolevulinic acid (5-ALA) was established as a remedial agent against PA-induced apoptosis of MAC-T cells (an established line of bovine MECs). In PA-treated cells, the apoptosis-related genes BCL2 and BAX were down- and upregulated, respectively. The elevated expression of major genes of the unfolded protein response (UPR), such as CHOP, a proapoptotic marker (C/EBP homologous protein), reduced the viability of PA-treated MAC-T cells. In contrast, 5-ALA pretreatment increased and decreased BCL2 and BAX expression, respectively. Moreover, cleaved caspase-3 protein expression was significantly reduced in the 5-ALA-pretreated group in comparison with the PA group. The downregulation of major UPR-related genes, including CHOP, extended the viability of MAC-T cells pretreated with 5-ALA and also reduced the enhanced intensity of the PA-induced expression of phospho-protein kinase R-like ER kinase. Moreover, the enhanced expression of HO-1 (antioxidant gene heme oxygenase) by 5-ALA reduced PA-induced oxidative stress (OxS). HO-1 is not only protective against OxS but also effective against ER stress. Collectively, these findings offer new insights into the protective effects of 5-ALA against PA-induced apoptosis of bovine MECs.

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