Changes in NMDA receptor subunit gene expression in the rat brain following withdrawal from forced long-term ethanol intake

2000 ◽  
Vol 361 (2) ◽  
pp. 206-213 ◽  
Author(s):  
M.B. Darstein ◽  
G.B. Landwehrmeyer ◽  
T.J. Feuerstein
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Rat Brain ◽  
Ethanol Intake ◽  
Receptor Subunit ◽  
Subunit Gene ◽  
Nmda Receptor Subunit

scholarly journals Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0134907 ◽  
Author(s):  
Yangfei Xiang ◽  
Kun-Yong Kim ◽  
Joel Gelernter ◽  
In-Hyun Park ◽  
Huiping Zhang
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Nmda Receptor ◽  
Embryonic Stem Cell ◽  
Cortical Neurons ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Receptor Subunit ◽  
Subunit Gene ◽  
Nmda Receptor Subunit

scholarly journals The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures

2021 ◽  
Author(s):  
Irena Smaga ◽  
Karolina Wydra ◽  
Agata Suder ◽  
Małgorzata Frankowska ◽  
Marek Sanak ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Rat Brain ◽  
Brain Structures ◽  
Extinction Training ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit ◽  
Cocaine Seeking ◽  
Instrumental Task ◽  
Seeking Behavior

AbstractDifferent neuronal alterations within glutamatergic system seem to be crucial for developing of cocaine-seeking behavior. Cocaine exposure provokes a modulation of the NMDA receptor subunit expression in rodents, which probably contributes to cocaine-induced behavioral alterations. The aim of this study was to examine the composition of the NMDA receptor subunits in the brain structures in rats with the history of cocaine self-administration after cocaine abstinence (i) in an enriched environment, (ii) in an isolated condition, (iii) with extinction training, or (iv) without instrumental task, as well as the Grin1 (encoding GluN1) and Grin2A (encoding GluN2A) gene expression were evaluated after 10-day extinction training in rat brain structures. In the present study, we observed changes only following cocaine abstinence with extinction training, when the increased GluN2A subunit levels were seen in the postsynaptic density fraction but not in the whole homogenate of the prelimbic cortex (PLC) and dorsal hippocampus (dHIP) in rats previously self-administered cocaine. At the same time, extinction training did not change the Grin1 and Grin2A gene expression in these structures. In conclusion, NMDA receptor subunit modulation observed following cocaine abstinence with extinction training may represent a potential target in cocaine-seeking behavior.

91. Early-life LPS administrations induce cognitive decline and changes in NMDA receptor subunit gene expression in the rodent brain

2014 ◽  
Vol 40 ◽  
pp. e26-e27
Author(s):  
K.J. Fomalont ◽  
E.A. Veniaminova ◽  
S.V. Kalemenev ◽  
A.N. Trofimov ◽  
A.P. Schwarz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Cognitive Decline ◽  
Early Life ◽  
Receptor Subunit ◽  
Subunit Gene ◽  
Nmda Receptor Subunit ◽  
Rodent Brain

Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice

2014 ◽  
Vol 136 ◽  
pp. 79-85 ◽  
Author(s):  
Ruby A. Holland ◽  
John J. Leonard ◽  
Nicholas A. Kensey ◽  
Paavali A. Hannikainen ◽  
Bart C. De Jonghe
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Receptor Subunit ◽  
Subunit Gene ◽  
Neuronal Activation ◽  
Nmda Receptor Subunit
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