Effects of K + channel openers on I K(ATP) of human atrial myocytes at physiological temperatures

2001 ◽  
Vol 363 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Brigitte Pelzmann ◽  
Peter Schaffer ◽  
Eva Bernhart ◽  
Petra Lang ◽  
Heinrich Mächler ◽  
...  
Keyword(s):  
K Channel ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes

Acetylcholine-sensitive potassium channels in human atrial myocytes

1990 ◽  
Vol 259 (6) ◽  
pp. H1730-H1735 ◽  
Author(s):  
R. Sato ◽  
I. Hisatome ◽  
J. A. Wasserstrom ◽  
C. E. Arentzen ◽  
D. H. Singer
Keyword(s):  
Single Channel ◽  
K Channel ◽  
Channel Activity ◽  
Atrial Myocytes ◽  
Open Probability ◽  
Human Atrial Myocytes ◽  
Open Time ◽  
Patch Pipette ◽  
Single Channel Activity ◽  
Gamma S

Single channel recording techniques were used to study acetylcholine (ACh)-sensitive K+ channel activity in human atrial myocytes isolated from specimens obtained during corrective cardiac surgery. Under conditions of cell-attached patch, the presence of ACh in the patch pipette activated K+ channels. Single channel activity occurred in periodic bursts. The channels exhibited a slope conductance of 46 +/- 2 pS inwardly (means +/- SD, n = 4). During a burst, both open and closed time histograms were fitted by a single exponential curve, suggesting the existence of one open and one closed state during a burst. Open probability increased directly with ACh concentration without affecting open time. The channel could be activated by GTP and guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) (in the presence and absence of ACh in the pipette, respectively). Slope conductance, the response to GTP and GTP gamma S, and the independence of activation from Ca2+ were similar to those for other species. In contrast, sensitivity to ACh appeared diminished compared with frog atrial myocytes.

scholarly journals A Trek-Like K+ Channel Current Inhibited by Norepinephrine in Rat Atrial Myocytes

2014 ◽  
Vol 106 (2) ◽  
pp. 120a
Author(s):  
Richard C. Bond ◽  
Stephanie C. Choisy ◽  
Simon M. Bryant ◽  
Jules C. Hancox ◽  
Andrew F. James
Keyword(s):  
K Channel ◽  
Atrial Myocytes ◽  
Channel Current

scholarly journals Sarcoplasmic reticulum and L-type Ca2+channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytes

2011 ◽  
Vol 589 (13) ◽  
pp. 3247-3262 ◽  
Author(s):  
Anna Llach ◽  
Cristina E. Molina ◽  
Jacqueline Fernandes ◽  
Josep Padró ◽  
Juan Cinca ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Calcium Handling ◽  
Channel Activity ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes
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