Critical role of P-selectin-dependent rolling in tumor necrosis factor-α-induced leukocyte adhesion and extravascular recruitment in vivo

2000 ◽  
Vol 362 (2) ◽  
pp. 190-196 ◽  
Author(s):  
Peter Månsson ◽  
Xiao Wei Zhang ◽  
Bengt Jeppsson ◽  
Olof Johnell ◽  
Henrik Thorlacius
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Leukocyte Adhesion ◽  
Critical Role ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Critical role of tumor necrosis factor-α in the early process of wound healing in skin

2017 ◽  
Vol 21 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Masae Ritsu ◽  
Kazuyoshi Kawakami ◽  
Emi Kanno ◽  
Hiromasa Tanno ◽  
Keiko Ishii ◽  
...  
Keyword(s):  
Wound Healing ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Critical Role ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor necrosis factor α (TNF-α) receptor-II is required for TNF-α–induced leukocyte-endothelial interaction in vivo

Blood ◽  
2006 ◽  
Vol 109 (5) ◽  
pp. 1938-1944 ◽  
Author(s):  
Unni M. Chandrasekharan ◽  
Maria Siemionow ◽  
Murat Unsal ◽  
Lin Yang ◽  
Earl Poptic ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Leukocyte Adhesion ◽  
Leukocyte Rolling ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor ◽  
Leukocyte Adhesion Molecules

Abstract Tumor necrosis factor-α (TNF-α) binds to 2 distinct cell-surface receptors: TNF-α receptor-I (TNFR-I: p55) and TNF-α receptor-II (TNFR-II: p75). TNF-α induces leukocyte adhesion molecules on endothelial cells (ECs), which mediate 3 defined steps of the inflammatory response; namely, leukocyte rolling, firm adhesion, and transmigration. In this study, we have investigated the role of p75 in TNF-α–induced leukocyte adhesion molecules using cultured ECs derived from wild-type (WT), p75-null (p75−/−), or p55-null (p55−/−) mice. We observed that p75 was essential for TNF-α–induced E-selectin, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1) expression. We also investigated the putative role of p75 in inflammation in vivo using an intravital microscopic approach with a mouse cremaster muscle model. TNF-α–stimulated leukocyte rolling, firm adhesion to ECs, and transmigration were dramatically reduced in p75−/− mice. Transplanted WT cremaster in p75−/− mice showed a robust leukocyte rolling and firm adhesion upon TNF-α activation, suggesting that the impairment in EC-leukocyte interaction in p75−/− mice is due to EC dysfunction. These results demonstrate, for the first time, that endothelial p75 is essential for TNF-α–induced leukocyte–endothelial-cell interaction. Our findings may contribute to the identification of novel p75-targeted therapeutic approaches for inflammatory diseases.

scholarly journals A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α

Glia ◽  
2017 ◽  
Vol 66 (3) ◽  
pp. 562-575 ◽  
Author(s):  
Sharifah Alawieyah Syed Mortadza ◽  
Joan A. Sim ◽  
Veronika E. Neubrand ◽  
Lin-Hua Jiang
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Microglial Activation ◽  
Tumor Necrosis Factor Α ◽  
Critical Role ◽  
Trpm2 Channel ◽  
Factor Α ◽  
Necrosis Factor
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