Influence of subchronic administration of oestradiol, ethinyloestradiol and oestradiol sulphamate on bile flow, bile acid excretion, and liver and biliary glutathione status in rats

1997 ◽  
Vol 71 (7) ◽  
pp. 443-449 ◽  
Author(s):  
Astrid Barth ◽  
Walter Elger ◽  
Birgitt Schneider ◽  
Sigfrid Schwarz
Keyword(s):  
Bile Acid ◽  
Bile Flow ◽  
Acid Excretion ◽  
Bile Acid Excretion ◽  
Glutathione Status

Bile Flow and Composition During Bile Acid Depletion and Administration

1974 ◽  
Vol 52 (2) ◽  
pp. 334-348 ◽  
Author(s):  
Curtis D. Klaassen
Keyword(s):  
Bile Acid ◽  
Bile Salt ◽  
Bile Acids ◽  
Bile Flow ◽  
Enterohepatic Circulation ◽  
Acid Excretion ◽  
Bile Formation ◽  
Bile Acid Excretion ◽  
Rat Bile ◽  
Acid Administration

Relatively similar concentrations of the inorganic ions were detected in rat, rabbit, and dog bile; however, dog bile had a higher concentration of protein, cholesterol, phospholipid phosphorous, and percentage solids than rat bile, and rabbit bile had the lowest concentration. The biliary excretion of bile acids was altered in each species by: (1) interruption of the enterohepatic circulation; (2) rapid administration of an exogenous load of bile acids; and (3) constant infusion of an exogenous load of bile acids. Bile acid and phospholipid phosphorous concentration and percentage solids increased after bile acid administration in all three species; however, species differences in bilirubin concentration were observed and a marked decrease was detected in rabbit and dog bile but it markedly increased in rat bile. When the enterohepatic circulation was interrupted in the dog and rat, the bile acid concentration markedly decreased with only minor changes in bile flow. This not only supports the theory that there is a bile salt independent fraction of bile formation, but also demonstrates that canalicular bile formation can be maintained at relatively normal rates with almost no excretion of bile acids. Marked discrepancy between bile acid excretion and bile flow was observed in the rat after bile acid administration, in that a marked increase in bile acid excretion was observed but little or no increase in flow. When bile flow was plotted against bile acid excretion for the three species, the slope of the line was less during bile acid administration than during depletion, indicating that the bile acids are accompanied by less water during bile acid administration than during depletion. Variation in the bile flow intercept with zero bile acid excretion (thought to represent the bile salt-independent fraction) was relatively large, which is probably due in part to alteration in the production of the bile salt independent fraction when bile acid secretion is altered. It appears that both the choleretic property of bile acids varies during various rates of bile acid excretion and the bile salt-independent fraction is not constant. Therefore, calculation of the bile salt independent fraction as previously performed should be interpreted with extreme caution. Thus, it appears difficult to determine the quantitative importance of bile acid excretion in bile formation.

Enhancing effects of vasoconstrictors on bile flow and bile acid excretion in the isolated perfused rat liver

1996 ◽  
Vol 52 (3) ◽  
pp. 489-495
Author(s):  
Makoto Hoshino ◽  
Akitaka Tanaka ◽  
Tomihiro Hayakawa ◽  
Takayuki Ohiwa ◽  
Kenji Katagiri ◽  
...  
Keyword(s):  
Bile Acid ◽  
Rat Liver ◽  
Bile Flow ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Acid Excretion ◽  
Bile Acid Excretion

scholarly journals Effect of sodium taurolithocholate on bile flow and bile acid excretion

1968 ◽  
Vol 47 (5) ◽  
pp. 1002-1014 ◽  
Author(s):  
Norman B. Javitt ◽  
Sidney Emerman
Keyword(s):  
Bile Acid ◽  
Bile Flow ◽  
Acid Excretion ◽  
Bile Acid Excretion

Regulatory volume decrease stimulates bile flow, bile acid excretion, and exocytosis in isolated perfused rat liver

1992 ◽  
Vol 262 (5) ◽  
pp. G806-G812 ◽  
Author(s):  
R. Bruck ◽  
P. Haddad ◽  
J. Graf ◽  
J. L. Boyer
Keyword(s):  
Bile Acid ◽  
Bile Flow ◽  
Sodium Taurocholate ◽  
Regulatory Volume Decrease ◽  
Acid Excretion ◽  
K Channels ◽  
Hypotonic Stress ◽  
Bile Acid Excretion ◽  
Second Peak ◽  
Volume Decrease

To study the effect of volume regulation on bile secretory function, isolated perfused rat livers (IPRL) were exposed to hypotonic stress (45 mM NaCl) while bile flow and the biliary excretion of bile acids and horseradish peroxidase (HRP) were assessed. Hypotonic stress induced a biphasic increase in bile flow, which rose in the first minute from 1.1 +/- 0.2 to 1.7 +/- 0.1 microliter.min-1.g liver-1 (P less than 0.01), an effect attributed to rapid osmotic equilibration of water, then increased further between 3 and 5 min to 1.6 +/- 0.1 microliter.min-1.g liver-1 (P less than 0.01, followed by a subsequent return to baseline. HRP excretion in bile increased during the second peak of bile flow from 0.9 +/- 0.2 to 1.1 +/- 0.2 ng.min-1.g liver-1, P less than 0.01. Pretreatment with colchicine but not lumicolchicine completely abolished the latter increase in bile flow and HRP excretion as did BaCl2 (1 mM), an inhibitor of both K+ channels and regulatory volume decrease (RVD) in hepatocytes. When sodium taurocholate was infused (1 mumol/min), hypotonic stress induced an even larger increase in the second peak of bile flow (5.1 +/- 0.7 microliters/g liver, P less than 0.01) and higher rates of bile acid excretion than in control perfusions with bile acid (126.2 +/- 21.0 vs. 99.0 +/- 17.1 nmol.min-1.g liver-1, P less than 0.05). These data suggest that both bile flow and bile acid excretion are stimulated during RVD by mechanisms that involve both K+ channels and microtubule-dependent exocytosis at the canalicular (apical) membrane domain.

scholarly journals Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits

1993 ◽  
Vol 34 (10) ◽  
pp. 1675-1685
Author(s):  
JA Poorman ◽  
RA Buck ◽  
SA Smith ◽  
ML Overturf ◽  
DS Loose-Mitchell
Keyword(s):  
Bile Acid ◽  
Acid Excretion ◽  
Bile Acid Excretion

Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice

Nutrition ◽  
2010 ◽  
Vol 26 (3) ◽  
pp. 321-330 ◽  
Author(s):  
Jungae Jeun ◽  
Sukyung Kim ◽  
Sung-Yun Cho ◽  
Hee-jin Jun ◽  
Hyun-Jin Park ◽  
...  
Keyword(s):  
Bile Acid ◽  
Lactobacillus Plantarum ◽  
Acid Excretion ◽  
Bile Acid Excretion

Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water

1999 ◽  
Vol 11 (4) ◽  
pp. 273-276 ◽  
Author(s):  
A. Capurso ◽  
V. Solfrizzi ◽  
F. Panza ◽  
F. Mastroianni ◽  
F. Torres ◽  
...  
Keyword(s):  
Bile Acid ◽  
Serum Cholesterol ◽  
Mineral Water ◽  
Acid Excretion ◽  
Bile Acid Excretion
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