Biochemical properties of the products of cytochrome P450 genes ( PDA ) encoding pisatin demethylase activity in Nectria haematococca

1998 ◽  
Vol 170 (3) ◽  
pp. 147-154 ◽  
Author(s):  
H. L. George ◽  
K. D. Hirschi ◽  
H. D. VanEtten
Keyword(s):  
Cytochrome P450 ◽  
Biochemical Properties ◽  
Nectria Haematococca ◽  
Pisatin Demethylase ◽  
Cytochrome P450 Genes ◽  
Demethylase Activity

scholarly journals Escalation of Pyrethroid Resistance in the Malaria Vector Anopheles funestus Induces a Loss of Efficacy of Piperonyl Butoxide–Based Insecticide-Treated Nets in Mozambique

2019 ◽  
Vol 220 (3) ◽  
pp. 467-475 ◽  
Author(s):  
Jacob M Riveron ◽  
Silvie Huijben ◽  
Williams Tchapga ◽  
Magellan Tchouakui ◽  
Murielle J Wondji ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Resistance Mechanisms ◽  
Piperonyl Butoxide ◽  
Insecticide Treated Nets ◽  
Molecular Analyses ◽  
Cytochrome P450 Genes ◽  
High Degree ◽  
Long Lasting Insecticidal Nets

Abstract Background Insecticide resistance poses a serious threat to insecticide-based interventions in Africa. There is a fear that resistance escalation could jeopardize malaria control efforts. Monitoring of cases of aggravation of resistance intensity and its impact on the efficacy of control tools is crucial to predict consequences of resistance. Methods The resistance levels of an Anopheles funestus population from Palmeira, southern Mozambique, were characterized and their impact on the efficacy of various insecticide-treated nets established. Results A dramatic loss of efficacy of all long-lasting insecticidal nets (LLINs), including piperonyl butoxide (PBO)–based nets (Olyset Plus), was observed. This An. funestus population consistently (2016, 2017, and 2018) exhibited a high degree of pyrethroid resistance. Molecular analyses revealed that this resistance escalation was associated with a massive overexpression of the duplicated cytochrome P450 genes CYP6P9a and CYP6P9b, and also the fixation of the resistance CYP6P9a_R allele in this population in 2016 (100%) in contrast to 2002 (5%). However, the low recovery of susceptibility after PBO synergist assay suggests that other resistance mechanisms could be involved. Conclusions The loss of efficacy of pyrethroid-based LLINs with and without PBO is a concern for the effectiveness of insecticide-based interventions, and action should be taken to prevent the spread of such super-resistance.

scholarly journals Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1and colorectal cancer risk

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Lara Bethke ◽  
Emily Webb ◽  
Gabrielle Sellick ◽  
Matthew Rudd ◽  
Stephen Penegar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cytochrome P450 ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Cytochrome P450 Genes
Sign in / Sign up

Export Citation Format

Share Document