Aggressive treatment of the first acute rejection episode using first-line anti-lymphocytic preparation reduces further acute rejection episodes after human kidney transplantation

1998 ◽  
Vol 11 (0) ◽  
pp. S86-S89 ◽  
Author(s):  
J. Theodorakis ◽  
H. Schneeberger ◽  
W. D. Illner ◽  
M. Stangl ◽  
B. Zanker ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Acute Rejection ◽  
Rejection Episode ◽  
Human Kidney ◽  
Acute Rejection Episode ◽  
Aggressive Treatment ◽  
First Line

scholarly journals The association between vitamin D and acute rejection in human kidney transplantation: A systematic review and meta-analysis study

2021 ◽  
pp. 101410
Author(s):  
Mohammad Mirzakhani ◽  
Sheyda Mohammadkhani ◽  
Shirin Hekmatirad ◽  
Soudabeh Aghapour ◽  
Negar Gorjizadeh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Meta Analysis ◽  
Human Kidney ◽  
Analysis Study

Correlations of Serum and Urine Levels of Neopterin, IL-8, IL-6, IL-6R, Basic Fetoprotein and Hepatocytes Growth Factor with Acute Rejection in kidney Transplantation

Pteridines ◽  
1998 ◽  
Vol 9 (1) ◽  
pp. 22-25
Author(s):  
Tsuneharu Miki ◽  
Shiro Takahara ◽  
Akihiko Okuyma
Keyword(s):  
Acute Rejection ◽  
Rejection Episode ◽  
Stable Condition ◽  
Serum Levels ◽  
Acute Rejection Episode ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Urinary Neopterin ◽  
Basic Fetoprotein ◽  
Urine Levels

Summary Levels of serum- and urinary-neopterin and serum-IL-6 and IL-6R of kidney transplant recipients "Were higher in acute rejection episode than in stable condition. IL-8 serum levels had risen prior to clinical diagnosis of acute rejection episode. Serum HGF levels also increased during acute rejection episode to over 1 ng/ml. Serum-neopterin and IL-6R levels were relatively sensitive for the detection of acute rejection episode.

scholarly journals Presence of Donor- and Recipient-derived DNA in Cell-free Urine Samples of Renal Transplantation Recipients: Urinary DNA Chimerism

1999 ◽  
Vol 45 (10) ◽  
pp. 1741-1746 ◽  
Author(s):  
Jun Zhang ◽  
Kwok-Lung Tong ◽  
Philip KT Li ◽  
Albert YW Chan ◽  
Chung-Kwong Yeung ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Renal Transplant ◽  
Acute Rejection ◽  
Quantitative Pcr ◽  
Graft Rejection ◽  
Rejection Episode ◽  
Urine Samples ◽  
Acute Rejection Episode ◽  
Organ Donors ◽  
Male Organ

Abstract Background: Previous studies have indicated that microchimerism is present in body tissues, peripheral blood, and plasma of recipients after organ transplantation. We hypothesize that donor-derived DNA may also be present in cell-free urine of renal transplant recipients and that the concentrations of urine DNA may be correlated with graft rejection. Methods: Thirty-one female patients who had renal transplantation were enrolled in the study. In women with male organ donors, the SRY gene on the Y chromosome was used as a marker for donor-derived DNA. Real-time quantitative PCR for the SRY and β-globin genes was carried out on cell-free urinary DNA from these patients. Serial urine samples from a female renal transplant recipient undergoing an acute rejection episode were also collected and analyzed with the β-globin quantitative PCR system. Results: SRY sequences were detected in the urine of 14 of 17 female patients with male organ donors. None of the 14 patients with female organ donors had detectable SRY sequences in urinary DNA. The median fractional concentration of donor-derived DNA was 8.7% (interquartile range, 1.9–26.4%). During the acute rejection episode, urinary concentrations of the β-globin gene were markedly increased, with the concentrations returning rapidly to normal following antirejection treatment. Conclusions: Our results demonstrate that urinary DNA chimerism is present following renal transplantation. The measurement of urinary DNA using quantitative PCR may be useful for the diagnosis and monitoring of graft rejection.

Epigenetic Analysis Demonstrates that Natural Treg Only Infiltrate the Cardiac Allograft During an Acute Rejection Episode

2012 ◽  
Vol 94 (10S) ◽  
pp. 1166
Author(s):  
K. Boer ◽  
A. M.A. Peeters ◽  
A. P.W.M. Maat ◽  
K. Caliskan ◽  
A. H.M.M. Balk ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Rejection Episode ◽  
Cardiac Allograft ◽  
Acute Rejection Episode ◽  
Epigenetic Analysis

scholarly journals High rate of acute rejections in renal allograft recipients with thrombophilic risk factors.

1998 ◽  
Vol 9 (7) ◽  
pp. 1309-1313 ◽  
Author(s):  
S Heidenreich ◽  
C Dercken ◽  
C August ◽  
H G Koch ◽  
U Nowak-Göttl
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Renal Allograft ◽  
Vascular Complications ◽  
Acute Rejection Episode ◽  
Renal Transplant Recipients ◽  
Vascular Events ◽  
Factor V Leiden Mutation ◽  
Thrombotic Risk

Inherited and acquired thrombophilic disorders predispose patients for thromboembolic and probably other occlusive vascular events that occur when additional risk factors play in concert. Because acute rejections in renal transplant recipients may reflect vascular events, and an impairment of the fibrinolytic system in immunosuppressed patients has been previously described, the implications of genetic or acquired risk factors of thrombophilia for the occurrence of early acute rejections after kidney transplantation were evaluated. The following risk factors of thrombophilia were determined in 97 patients after cadaveric kidney transplantation: factor V Leiden mutation, protein S, protein C, and antithrombin deficiency. In a retrospective analysis, the prevalence of acute rejections, the histologic classification when rejection episodes had been confirmed by biopsy, and other vascular complications were evaluated. In 21 of the 97 patients, an inherited or acquired risk factor of thrombophilia was detected. Prevalence of acute rejections was 71% in the first 6 mo after transplantation in patients with a thrombophilic disorder and significantly higher compared with patients without thrombophilia (41%; P = 0.017). The distribution of classic risk factors associated with acute rejections, such as number of human leukocyte antigen mismatches or percentage of panel-reactive antibodies, was similar in patients with and without thrombophilia. In the eight patients with thrombophilia and histologically proven acute rejection, four patients had an acute vascular rejection, and in two patients a vascular involvement was suspected. Furthermore, prevalence of cerebral or coronary vascular disease, or venous thromboembolic complications, was significantly higher in patients with a thrombophilic clotting defect (67%) compared with patients with normal hemostasis parameters (28%; P < 0.002). It is concluded that renal allograft recipients with thrombophilia are at risk of developing an acute rejection or other vascular event. Although the determination of thrombotic risk factors was performed at least 3 mo after an acute rejection episode, it can be presumed that acute rejection episodes are associated with subsequent coagulatory abnormalities with further consequences for transplant survival. Thus, pretransplant evaluation of genetic and acquired risk factors of thrombophilia is recommended.

scholarly journals The Association Between Vitamin D and Acute Rejection in Human Kidney Transplantation: A Systematic Review and Meta-analysis Study

2021 ◽  
Author(s):  
Mohammad Mirzakhani ◽  
Sheyda Mohammadkhani ◽  
Shirin Hekmatirad ◽  
Soudabeh Aghapour ◽  
Negar Gorjizadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Web Of Science ◽  
Meta Analysis ◽  
Human Kidney ◽  
Before And After ◽  
And Gender ◽  
Role Of It

Abstract Background: Vitamin D (VitD) deficiency is associated with several diseases such as multiple sclerosis, rheumatoid arthritis, respiratory infection, and so forth. In the field of transplantation (kidney transplantation), some studies reported that patients with VitD deficiency are of increased chance of acute rejection, but other studies did not show such a chance. On the other hand, since VitD is a modulatory factor and can reduce the inflammatory response, understanding the exact role of it in transplantation may contribute to tolerance condition in these patients.Methods: The electronic databases, including PubMed, Scopus, Embase, ProQuest, Web of Science, and Google Scholar, were searched for eligible studies. In general, 14 studies with a total of 4,770 patients were included in this meta-analysis. Regarding the methodological heterogeneity, we selected a random-effects combination model. Moreover, OR was chosen as an effect size for this study.Results: After the combination of 14 studies, we showed that patients in the VitD-deficient group had an 82% increased chance of acute rejection compared with patients in the VitD-sufficient group, and this effect was significant (OR 1.82; 95% confidence interval [CI] [1.29, 2.56]; I2 = 52.3%). This result was significant, and, regarding the narrow CI, it can be a conclusive result. Study quality and gender variables were the main sources of inconsistent results in the primary studies. Moreover, using meta-regression, we showed that VitD deficiency (independent from the estimated glomerular filtration rate (eGFR) of patients) increased the chance of acute rejection.Conclusion: The normal VitD status of patients a few days before and after transplantation can reduce the risk of acute rejection, as it has definite modulatory effects on immune cells.

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