Prompt treatment of initial acute rejection episodes may improve long-term graft outcome

1998 ◽  
Vol 11 (0) ◽  
pp. S3-S4 ◽  
Author(s):  
S. G. Tullius ◽  
M. Nieminen ◽  
W. O. Bechstein ◽  
S. Jonas ◽  
Y. Qun ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Prompt Treatment ◽  
Graft Outcome

scholarly journals Prompt treatment of initial acute rejection episodes may improve long-term graft outcome

1998 ◽  
Vol 11 (s1) ◽  
pp. S3-S4 ◽  
Author(s):  
S.G. Tullius ◽  
M. Nieminen ◽  
W.O. Bechstein ◽  
S. Jonas ◽  
Y. Qun ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Prompt Treatment ◽  
Graft Outcome

The Influence of Late Acute Rejection Episodes on Long-Term Graft Outcome After Liver Transplantation

2005 ◽  
Vol 37 (4) ◽  
pp. 1716-1717 ◽  
Author(s):  
G. Junge ◽  
S.G. Tullius ◽  
V. Klitzing ◽  
L. Schewior ◽  
J. Pratschke ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Graft Outcome

scholarly journals Long-Term Results of TPMT Activity Monitoring in Azathioprine-Treated Renal Allograft Recipients

2001 ◽  
Vol 12 (1) ◽  
pp. 170-176
Author(s):  
ERIC THERVET ◽  
DANY ANGLICHEAU ◽  
NATHALIE TOLEDANO ◽  
ANNE-MARIE HOULLIER ◽  
LAURE-HÉLÈNE NOEL ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Graft Survival ◽  
Renal Allograft ◽  
Long Term Results ◽  
Tpmt Activity ◽  
Acute Rejection Episode ◽  
Blood Levels ◽  
Graft Outcome ◽  
Activity Induction

Abstract. Thiopurine methyltransferase (TPMT) is implicated in the metabolism of azathioprine. The consequences of differential TPMT activity induction by azathioprine on the long-term results after renal transplantation were investigated. The erythrocyte TPMT activity in 82 patients on days 0, 7, and 30 was prospectively evaluated. Because various patterns of TPMT activity variation were noted, the population was subsequently divided between inductors (n = 47) and noninductors (n = 35). Data regarding patient and graft survival and acute rejection episodes were collected. Renal allograft assessment was performed at 3 mo and 2 yr to evaluate the renal function and the histologic lesions on routine biopsies. Data regarding azathioprine-related toxicity also were collected. In a subgroup of patients (n = 19), azathioprine blood levels were determined at day 7 and day 30. The graft survival censoring death was statistically improved in TPMT inductor patients when compared with non-TPMT inductors (P < 0.05). Among TPMT inductors, an acute rejection episode was observed in 34% of the patients versus 69% among non-TPMT inductors (P = 0.002). At 3 mo, serum creatinine was significantly lower among TPMT inductors when compared with non-TPMT inductors (123.1 ± 7.6 and 161.4 ± 13.9 μmol/L, respectively; P = 0.01). On routine allograft biopsies at 2 yr (n = 61), grade 2 or 3 chronic lesions were present in 19% versus 25%, respectively (P = NS). At days 7 and 30, the azathioprine blood levels were higher among patients who experienced acute rejection (P < 0.02). TPMT activity induction was observed in 57% of renal transplant recipients who received azathioprine. This induction was associated with better graft outcome. The appropriate conversion from azathioprine, which is a pro-drug, into 6-mercaptopurine could explain both better graft outcome and TPMT induction. Assessing the ability of azathioprine metabolism at an individualized level before transplantation may allow a more accurate choice among the different immunosuppressive treatments.

NFATC1genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients

2017 ◽  
Vol 18 (4) ◽  
pp. 381-392 ◽  
Author(s):  
Qinxia Xu ◽  
Xiaoyan Qiu ◽  
Zheng Jiao ◽  
Ming Zhang ◽  
Jianping Chen ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Acute Rejection ◽  
Graft Function ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Association of Factor V Leiden Mutation with Delayed Graft Function, Acute Rejection Episodes and Long-term Graft Dysfunction in Kidney Transplant Recipients

2002 ◽  
Vol 87 (02) ◽  
pp. 194-198 ◽  
Author(s):  
Torsten Slowinski ◽  
Ingeborg Hauser ◽  
Birgit Vetter ◽  
Lutz Fritsche ◽  
Daniela Bachert ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Kidney Transplant ◽  
Graft Function ◽  
Factor V Leiden ◽  
Factor V ◽  
Transplant Recipients ◽  
Graft Dysfunction ◽  
Kidney Transplant Recipients ◽  
Factor V Leiden Mutation

SummaryWe analysed whether the factor V Leiden mutation – the most common hereditary predisposing factor for venous thrombosis – is associated with early and long-term graft dysfunction after kidney transplantation in 394 Caucasian kidney transplant recipients. The presence of factor V Leiden mutation was identified by allele specific PCR. The prevalence of the factor V Leiden mutation was compared to 32216 unselected neonates. The prevalence of the factor V Leiden mutation (GA genotype) was similar in 394 kidney transplant recipients and 32216 neonates. The frequency of known factors predicting long-term graft function were similar in patients with the GA genotype and with the normal factor V gene (GG genotype). The GA genotype was associated with the occurrence of no primary graft function (risk: 2.87; 95% confidence interval: 1.01-8.26; p < 0.05), the number of dialysis after transplantation in patients with no primary graft function until graft function (7.5 ± 2.06 dialysis in GA patients; 4.2 ± 0.36 dialyses in GG patients; p < 0.05), and the risk for at least one acute rejection episode (risk: 3.83; 95% confidence interval: 1.38-10.59; p < 0.02). The slope of 1/creatinine per year was significantly lower in patients with the GA genotype (GA patients: – 0.0204 ± 0.008 dl/mg per year; GG patients: 0.0104 ± 0.004 dl/mg per year; p < 0.02). The annual enhancement of the daily protein excretion rate was elevated in patients with the GA genotype (GA patients: 38.5 ± 16.6 mg/24 h per year; GG patients: 4.9 ± 4.4 mg/24 h per year; p < 0.02). Our study showed that the factor V Leiden mutation is associated with the occurrence of delayed graft function, acute rejection episodes and chronic graft dysfunction after kidney transplantation.

scholarly journals HYPOLIPIDEMIC THERAPY IN PATIENTS AFTER HEART TRANSPLANTATION: STATINS

2016 ◽  
Vol 18 (2) ◽  
pp. 171-176
Author(s):  
A. О. Shevchenko
Keyword(s):  
Acute Rejection ◽  
Heart Transplantation ◽  
Statin Therapy ◽  
Standard Therapy ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Allograft Vasculopathy ◽  
Hypolipidemic Action ◽  
Long Term Prognosis

Statins should be used as a part of standard therapy in patients after heart transplantation. The effectiveness of statins is associated not only with their hypolipidemic action, but also with their immunomodulatory and antineoplastic properties. Statin therapy initiated early after heart transplantation improves the shortand long-term prognosis and outcomes, leading to a reduction in the incidence of cardiac allograft vasculopathy, acute rejection, and cancer. 

The Effect of Acute Rejection Episodes According to Banff 2009 on Long-Term Outcome of Patients after Kidney Transplantation

2012 ◽  
Vol 94 (10S) ◽  
pp. 1044
Author(s):  
K. Wu ◽  
B. Rudolph ◽  
L. Huber ◽  
D. Schmidt ◽  
L. Liefeldt ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Acute Rejection ◽  
Term Outcome ◽  
Long Term Outcome

Intragraft vasculitis and gene expression analysis: Association with acute rejection and prediction of mortality in long-term heart transplantation

2018 ◽  
Vol 32 (10) ◽  
pp. e13373
Author(s):  
Hui Tzu Lin-Wang ◽  
Reginaldo Cipullo ◽  
João Italo Dias França ◽  
Marco Aurelio Finger ◽  
Joao Manoel Rossi Neto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Rejection ◽  
Heart Transplantation ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Prediction Of Mortality

MO921PROGNOSTIC OUTCOMES OF TRANSPLANTED KIDNEY USING SOLUBLE  CD30 AND Β2- MICROGLOBULIN

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Ahmed Abo omar ◽  
Gamal Saadi
Keyword(s):  
Acute Rejection ◽  
Graft Survival ◽  
Patient Group ◽  
The Other ◽  
Kidney Graft ◽  
Post Transplantation ◽  
Β2 Microglobulin ◽  
Transplanted Kidney ◽  
Successful Transplantation

Abstract Background and Aims Transplantation is the first successful modality of renal replacement therapy (RRT) for irreversible chronic kidney disease (CKD; stage 5). Identifying additional factors associated with poor long-term prognosis after transplantation may provide clues regarding the pathophysiological mechanisms involved in allograft failure and identify high-risk patients who may benefit from additional monitoring or interventions. Successful kidney transplantation results in a substantial decrease in β2M levels, but a delayed decrease or increasing levels after transplantation may serve as a marker of acute rejection or inflammation. Several reports show that elevated sCD30 levels, pre and post transplantation are associated with a poor prognosis for long term kidney graft survival. These studies found higher CD30 levels in allograft recipients and a good predictor of impending acute rejection. The aim of the work is to study the prognostic outcomes of transplanted kidney using CD30 and β2-Microglobulin Method prospective study was conducted in nephrology unit –internal medicine department at Tanta and Kasr El Ainy university ,over 1 year.20 patients subjected to primary Tx.participated in this study.Cd30 and β2M.at day -1,2weeks and 3 months,with clinical follow up after 1 year to detect graft survival Results At day -1,level of cd30 was higher in rejection group than the other patient group.2 weeks post transplantation ,level of cd30 was higher in rejection group than the other patient group and at 3 monthes post transplantation level of cd30 was higher in rejection group than the other patient group,and these differences are statistically highly significant.(p values :0.003 ,0.005 and 0.002 respectively) Successful transplantation leads to significant decrease in serum cd30 at 2 weeks post tx.(P1 &lt;0.005) and at 3 monthes post tx. (P1&lt;0.001) although in rejection group, significant decrease in cd30 was at 2 weeks post tx.only(P1&lt;0.005) and at 3 monthes serum cd30 began to rise again with( P1 0.157). At day -1,level of β2microglobulin was higher in rejection group than the other patient groupwith statistically significant difference (p. 0.01).2 weeks post transplantation ,level of β2microglobulin was higher in rejection group than the other patient groupbut statistically not significant(p. 0.18 ) and at 3 monthes post transplantation level of β2microglobulin was higher in rejection group than the other patient group but statistically non significant(p. 0.18 ). Successful transplantation leads to significant decrease in serum β2microglobulin at 2 weeks post tx.(P1 &lt;0.002) and at 3 monthes post tx. (P1&lt;0.001) although in rejection group ,significant decrease in β2microglobulin was at 3 monthes post tx.only(P1&lt;0.005) and at 2 weeks no significant decrease(p1 0.15) Conclusion pre transplantation high Cd30 and β2M is associated with poor outcome.failure of decrease of cd30 and β2M post Tx. also associated with poor outcome or infection. Successful transplantation leads to significant decrease in serum cd30 and β2M. which can be used as predictors of graft survival with better sensitivity and specificity than serum creatinin.

Kidney Weight and Recipient Body Weight Ratio Predict Long-Term Graft Outcome.

2014 ◽  
Vol 98 ◽  
pp. 612-613
Author(s):  
A. Akdur ◽  
M. Kirnap ◽  
E. Kolsarici ◽  
S. Yildirim ◽  
G. Moray ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Ratio ◽  
Body Weight Ratio ◽  
Kidney Weight ◽  
Graft Outcome
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