Delayed toxicity in acute ethanol-methanol copoisoning in a chronic alcohol abuser: usefulness of continuous 4-methylpyrazole (fomepizole) infusion

2000 ◽  
Vol 26 (6) ◽  
pp. 827-828 ◽  
Author(s):  
E. Hazouard ◽  
M. Ferrandière ◽  
G. Paintaud ◽  
D. Perrotin
Keyword(s):  
Chronic Alcohol ◽  
Alcohol Abuser ◽  
Chronic Alcohol Abuser ◽  
Acute Ethanol ◽  
Delayed Toxicity

Fulminant Pasteurella multocida lung abscess in a chronic alcohol abuser: diagnosis using intracavital lavage

2000 ◽  
Vol 26 (9) ◽  
pp. 1404-1405 ◽  
Author(s):  
E. Hazouard ◽  
M. Ferrandière ◽  
L. Brunereau ◽  
D. Garot ◽  
E. Lanotte
Keyword(s):  
Pasteurella Multocida ◽  
Lung Abscess ◽  
Chronic Alcohol ◽  
Alcohol Abuser ◽  
Chronic Alcohol Abuser

scholarly journals Improving cerebral oxygenation, cognition and autonomic nervous system control of a chronic alcohol abuser through a three-month running program

2017 ◽  
Vol 6 ◽  
pp. 83-89 ◽  
Author(s):  
Daniel Aranha Cabral ◽  
Kell Grandjean da Costa ◽  
Alexandre Hideki Okano ◽  
Hassan Mohamed Elsangedy ◽  
Vanessa Paula Rachetti ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Cerebral Oxygenation ◽  
System Control ◽  
Chronic Alcohol ◽  
Autonomic Nervous ◽  
Alcohol Abuser ◽  
Chronic Alcohol Abuser

scholarly journals Acute and chronic ethanol consumption differentially impact pathways limiting hepatic protein synthesis

2008 ◽  
Vol 295 (1) ◽  
pp. E3-E9 ◽  
Author(s):  
Anne M. Karinch ◽  
Jonathan H. Martin ◽  
Thomas C. Vary
Keyword(s):  
Protein Synthesis ◽  
Alcohol Intoxication ◽  
Ethanol Consumption ◽  
Chronic Alcohol ◽  
Ethanol Intoxication ◽  
Initiation Factors ◽  
Eif2α Phosphorylation ◽  
Acute Ethanol ◽  
Acute Ethanol Intoxication ◽  
Hepatic Protein Synthesis

This review identifies the various pathways responsible for modulating hepatic protein synthesis following acute and chronic alcohol intoxication and describes the mechanism(s) responsible for these changes. Alcohol intoxication induces a defect in global protein synthetic rates that is localized to impaired translation of mRNA at the level of peptide-chain initiation. Translation initiation is regulated at two steps: formation of the 43S preinitiation complex [controlled by eukaryotic initiation factors 2 (eIF2) and 2B (eIF2B)] and the binding of mRNA to the 40S ribosome (controlled by the eIF4F complex). To date, alcohol-induced alterations in eIF2 and eIF2B content and activity are best investigated. Ethanol decreases eIF2B activity when ingested either acutely or chronically. The reduced eIF2B activity most likely is a consequence of twofold increased phosphorylation of the α-subunit of eIF2 on Ser51 following acute intoxication. The increase in eIF2α phosphorylation after chronic alcohol consumption is the same as that induced by acute ethanol intoxication, and protein synthesis is not further reduced by long-term alcohol ingestion despite additional reduced expression of initiation factors and elongation factors. eIF2α phosphorylation alone appears sufficient to maximally inhibit hepatic protein synthesis. Indeed, pretreatment with Salubrinal, an inhibitor of eIF2α(P) phosphatase, before ethanol treatment does not further inhibit protein synthesis or increase eIF2α phosphorylation, suggesting that acute ethanol intoxication causes maximal eIF2α phosphorylation elevation and hepatic protein synthesis inhibition. Ethanol-induced inhibition of hepatic protein synthesis is not rapidly reversed by cessation of ethanol consumption. In conclusion, sustained eIF2α phosphorylation is a hallmark of excessive alcohol intake leading to inhibition of protein synthesis. Enhanced phosphorylation of eIF2α represents a unique response of liver to alcohol intoxication, because the ethanol-induced elevation of eIF2α(P) is not observed in skeletal muscle or heart.

scholarly journals Morphometric Methods for Examining the Liver in the Diagnosis of Acute and Chronic Alcohol Intoxication

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Porodenko VA
Keyword(s):  
Connective Tissue ◽  
Blood Circulation ◽  
Alcohol Intoxication ◽  
Morphometric Study ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication ◽  
Pathological Conditions ◽  
Morphometric Methods ◽  
Acute Ethanol ◽  
Acute Ethanol Intoxication

The article presents the results of a morphometric study of the liver of persons who died from acute ethanol intoxication and chronic alcohol intoxication in persons with alcohol-induced liver pathology. The aim of the work was to carry out morphometry of the main vascular and parenchymal structural components of the liver, reflecting its morphological and functional state. Data were obtained on a decrease in the area of the vascular bed, cyto- and karyometric parameters, which reflect an increase in dystrophic processes in hepatocytes and inflammatory-proliferative processes in the connective tissue and indicate the tension of capillary-connective tissue structures, impaired blood circulation, bile and lymph outflow in the liver in chronic alcohol intoxication, especially with hepatitis and cirrhosis. The obtained morphometric data can be used as a comparison in studying the pathomorphological features of the liver in other pathological conditions.

Effects of Green Tea Extract on Acute Ethanol-induced Hepatotoxicity in Rats

2010 ◽  
Vol 39 (3) ◽  
pp. 343-349 ◽  
Author(s):  
Dong-Chun Jin ◽  
Seung-Wook Jeong ◽  
Pyoung-Sim Park
Keyword(s):  
Green Tea ◽  
Green Tea Extract ◽  
Acute Ethanol ◽  
Tea Extract
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