Effect of enteral versus parenteral feeding on hepatic blood flow and steady state propofol pharmacokinetics in ICU patients

1998 ◽  
Vol 24 (8) ◽  
pp. 795-800 ◽  
Author(s):  
N. Van Brandt ◽  
P. Hantson ◽  
Y. Horsmans ◽  
P. Mahieu ◽  
R. K. Verbeeck
Keyword(s):  
Blood Flow ◽  
Steady State ◽  
Hepatic Blood Flow ◽  
Parenteral Feeding ◽  
Icu Patients

Effects of liver blood flow on hepatic uptake kinetics of galactose in anesthetized cats: parallel tube model

1987 ◽  
Vol 65 (6) ◽  
pp. 1193-1199 ◽  
Author(s):  
C. V. Greenway ◽  
F. J. Burczynski
Keyword(s):  
Blood Flow ◽  
Steady State ◽  
Hepatic Blood Flow ◽  
Venous Blood ◽  
Liver Blood Flow ◽  
Control Flow ◽  
Tube Model ◽  
Blood Flows ◽  
Parallel Tube ◽  
Parallel Tube Model

Hepatic galactose uptake in cats anesthetized with pentobarbital was determined during (i) steady-state infusions at several doses, (ii) rapidly increasing infusion rates at different blood flows, and (iii) prolonged infusion of a single dose at different blood flows. The hepatic venous long-circuit technique was used to allow frequent sampling of arterial, portal, and hepatic venous blood without depletion of the animal's blood volume and to allow measurement and alteration of total hepatic blood flow. Uptake was shown to follow Michaelis–Menten kinetics and was consistent with the "parallel tube model." The kinetic parameters Vmax and Kmax could be determined under steady-state and nonsteady-state conditions and were independent of hepatic blood flow over the range 60–150% of control flow. Mean Vmax was 80 μmol/(min∙100 g liver) and mean Km was 215 μM. Vmax declined by 50% when flow was reduced to half normal. It is concluded that the parallel tube model can be used to describe and predict hepatic galactose kinetics in anesthetized cats, although other models may fit the data equally well.

Bedside micro-method for measuring effective hepatic blood flow, with use of first-order galactose clearance pharmacokinetics.

1985 ◽  
Vol 31 (9) ◽  
pp. 1557-1559 ◽  
Author(s):  
E B Rypins ◽  
H Sankary ◽  
M J Wynn
Keyword(s):  
Blood Flow ◽  
Steady State ◽  
Hepatic Blood Flow ◽  
Small Sample ◽  
Galactose Oxidase ◽  
Laboratory Animals ◽  
Constant Infusion ◽  
Metabolic Clearance ◽  
First Order ◽  
Hepatic Diseases

Abstract Data from first-order galactose clearance were used to estimate "effective" hepatic blood flow in normal subjects and in patients with hepatic diseases. Galactose clearance was determined by infusing galactose intravenously at a constant rate and measuring its resulting steady-state concentration in blood. The infusion rate must not exceed the maximum rate of galactose clearance by the liver, the "galactose elimination capacity." With this constraint and within the physiological and pathophysiological limits of hepatic blood flow, a constant infusion at 50 mg/min results in steady-state concentrations ranging from 20 to 200 mg/L. To measure galactose within this range, we modified a YSI Model 23A glucose analyzer and, using an immobilized galactose oxidase (EC 1.1.3.9)/hydrogen peroxide electrode system, accurately measured galactose in water and blood. The galactose metabolic clearance rate was calculated for six normal rats and for a normal and a cirrhotic human subject. The speed of the analysis (40 s), the small sample required (25 microL), and the suitability of fresh whole blood as the sample make the method ideal for measuring hepatic blood flow in small laboratory animals as well as for determining at bedside the effective hepatic blood flow in humans.

Hepatic Blood Flow in Patients with Tumors of the Liver

1963 ◽  
Vol 44 (6) ◽  
pp. 733-739 ◽  
Author(s):  
Kathleen M. Wartnaby ◽  
I.A.D. Bouchier ◽  
C.E. Pope ◽  
Sheila Sherlock
Keyword(s):  
Blood Flow ◽  
Hepatic Blood Flow ◽  
Tumors Of The Liver

External Recording Method for Estimating Hepatic Blood Flow With the Use of Radiogold

1959 ◽  
Vol 36 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Joseph S. Burkle ◽  
Marvin L. Gliedman
Keyword(s):  
Blood Flow ◽  
Hepatic Blood Flow ◽  
Recording Method

The Clearance of 133Xenon from the Liver Intraportal Injection in Man

1965 ◽  
Vol 05 (03) ◽  
pp. 241-245 ◽  
Author(s):  
K.-F. Aronsen ◽  
B. Ericsson ◽  
A. Fajgelj ◽  
S.-E. Lindell
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Blood Flow ◽  
Scintillation Detectors ◽  
Disappearance Rate ◽  
Simultaneous Measurements

Summary 133Xe dissolved in saline was injected into the portal vein in man. Hepatic blood flow was calculated from the disappearance rate of 133Xe recorded with scintillation detectors placed over the liver. The results are discussed and related to simultaneous measurements of the pressure in the portal vein.

Hepatic Blood Flow with Colloidal 198Au in the Diagnosis of Chronic Hepatitis in Children

1975 ◽  
Vol 14 (02) ◽  
pp. 158-162
Author(s):  
Viorica Szantay ◽  
Lidia Marian
Keyword(s):  
Blood Flow ◽  
Chronic Hepatitis ◽  
Hepatic Blood Flow ◽  
Hepatitis A ◽  
Clinical Findings ◽  
Active Chronic Hepatitis ◽  
Normal Children ◽  
Function Tests ◽  
Biochemical Function ◽  
Diagnostic Criterion

SummaryTracer quantities of colloidal 198Au were used to estimate the hepatic blood flow in normal children and in children with active or progressive chronic hepatitis and also to obtain scintigrams of the liver.In active chronic hepatitis a significant decrease in HBF values was observed, suggesting that the method may be used as a diagnostic criterion which is superior to hepatic scintigraphy.In progressive chronic hepatitis HBF values even lower than those in active hepatitis were observed. Together with more characteristic clinical findings and abnormal results of biochemical function tests, they underline the value of the method in estimating the severity and the evolution of the disease.

Clinical Application of Radiofrequency Ablation for Malignant Liver Tumor during Interruption of Hepatic Blood Flow

2000 ◽  
Vol 18 ◽  
pp. 121-125
Author(s):  
Takashi Shibata ◽  
Takahiro Niinobu ◽  
Masashi Kitada ◽  
Takashi Shimano ◽  
Motohisa Takami ◽  
...  
Keyword(s):  
Blood Flow ◽  
Radiofrequency Ablation ◽  
Clinical Application ◽  
Hepatic Blood Flow ◽  
Liver Tumor ◽  
Malignant Liver Tumor ◽  
Malignant Liver
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