Assessment of functional residual capacity using nitrogen washout and plethysmographic techniques in infants with and without bronchopulmonary dysplasia

1998 ◽  
Vol 24 (5) ◽  
pp. 469-475 ◽  
Author(s):  
R. R. Wauer ◽  
T. Maurer ◽  
T. Nowotny ◽  
G. Schmalisch
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Functional Residual Capacity ◽  
Nitrogen Washout ◽  
Residual Capacity

scholarly journals In vitro and in vivo functional residual capacity comparisons between multiple-breath nitrogen washout devices

2017 ◽  
Vol 3 (4) ◽  
pp. 00011-2017 ◽  
Author(s):  
Katrina O. Tonga ◽  
Paul D. Robinson ◽  
Claude S. Farah ◽  
Greg G. King ◽  
Cindy Thamrin
Keyword(s):  
Functional Residual Capacity ◽  
Measurement Accuracy ◽  
Lung Model ◽  
Nitrogen Washout ◽  
Device Validation ◽  
Residual Capacity

Functional residual capacity (FRC) accuracy is essential for deriving multiple-breath nitrogen washout (MBNW) indices, and is the basis for device validation. Few studies have compared existing MBNW devices. We evaluated in vitro and in vivo FRC using two commercial MBNW devices, the Exhalyzer D (EM) and the EasyOne Pro LAB (ndd), and an in-house device (Woolcock in-house device, WIMR).FRC measurements were performed using a novel syringe-based lung model and in adults (20 healthy and nine with asthma), followed by plethysmography (FRCpleth). The data were analysed using device-specific software. Following the results seen with ndd, we also compared its standard clinical software (ndd v.2.00) with a recent upgrade (ndd v.2.01).WIMR and EM fulfilled formal in vitro FRC validation recommendations (>95% of FRC within 5% of known volume). Ndd v.2.00 underestimated in vitro FRC by >20%. Reanalysis using ndd v.2.01 reduced this to 11%, with 36% of measurements ≤5%. In vivo differences from FRCpleth (mean±sd) were 4.4±13.1%, 3.3±11.8%, −20.6±11% (p<0.0001) and −10.5±10.9% (p=0.005) using WIMR, EM, ndd v.2.00 and ndd v.2.01, respectively.Direct device comparison highlighted important differences in measurement accuracy. FRC discrepancies between devices were larger in vivo, compared to in vitro results; however, the pattern of difference was similar. These results represent progress in ongoing standardisation efforts.

Validation of a nitrogen washout system to measure functional residual capacity in premature infants with hyaline membrane disease

1995 ◽  
Vol 20 (6) ◽  
pp. 403-409 ◽  
Author(s):  
Jason Miller ◽  
Amy B. Law ◽  
Robert A. Parker ◽  
Håkan W. Sundell ◽  
Daniel P. Lindstrom ◽  
...  
Keyword(s):  
Premature Infants ◽  
Functional Residual Capacity ◽  
Hyaline Membrane Disease ◽  
Nitrogen Washout ◽  
Hyaline Membrane ◽  
Residual Capacity

Alveolar-arterial O2 differences during artificial respiration in man

1959 ◽  
Vol 14 (5) ◽  
pp. 694-700 ◽  
Author(s):  
M. Jack Frumin ◽  
Norman A. Bergman ◽  
Duncan A. Holaday ◽  
Herbert Rackow ◽  
Ernest Salanitre
Keyword(s):  
Functional Residual Capacity ◽  
Artificial Respiration ◽  
Arterial Oxygen ◽  
Expiratory Resistance ◽  
Nitrogen Washout ◽  
Residual Capacity ◽  
Arterial Tension

Alveolar-arterial oxygen differences were determined in anesthetized, paralyzed man. Approximately 20% of the determinations showed a Pa-a O2 of greater than 20 mm Hg. The arterial tension rose an average of 10 mm Hg when the expiratory pressure was increased from -5 to +5 mm Hg. The insertion of a 3-mm orifice expiratory resistance increased the arterial O2 tension an average of 7 mm Hg. The causes for these variations in arterial O2 tension and saturation are discussed. The functional residual capacity at +5 and -5 mm Hg expiratory pressure were determined by the nitrogen washout technique. The theoretically expected changes in alveolar O2 tension due to differences in the functional residual capacity accounted for only a third or less of the experimentally observed changes in arterial saturations and tensions. Submitted on February 6, 1959

Physical effects of heliox versus oxygen on measurements of functional residual capacity by the nitrogen washout technique in small lung volumes: A model study

2001 ◽  
Vol 31 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Roland Hentschel ◽  
Andreas Suska ◽  
Andreas Volbracht ◽  
Erik Harms ◽  
Hellmut Haberland ◽  
...  
Keyword(s):  
Functional Residual Capacity ◽  
Lung Volumes ◽  
Nitrogen Washout ◽  
Model Study ◽  
Residual Capacity ◽  
Physical Effects
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