scholarly journals Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1β-exposed human and rat islet cells

Diabetologia ◽  
2001 ◽  
Vol 44 (3) ◽  
pp. 325-332 ◽  
Author(s):  
M.-C. Chen ◽  
P. Proost ◽  
C. Gysemans ◽  
C. Mathieu ◽  
D. L. Eizirik
Keyword(s):  
Pancreatic Islets ◽  
Islet Cells ◽  
Nod Mice ◽  
Interleukin 1Β ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Tranilast inhibits interleukin-1β-induced monocyte chemoattractant protein-1 expression in rat mesangial cells

2001 ◽  
Vol 427 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Akihiro Chikaraishi ◽  
Junichi Hirahashi ◽  
Osamu Takase ◽  
Takeshi Marumo ◽  
Keiichi Hishikawa ◽  
...  
Keyword(s):  
Mesangial Cells ◽  
Interleukin 1Β ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

scholarly journals Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1β and hCG in human endometrial cells

2004 ◽  
Vol 19 (11) ◽  
pp. 2465-2473 ◽  
Author(s):  
Jihong Kang ◽  
Ali Akoum ◽  
Pierre Chapdelaine ◽  
Philippe Laberge ◽  
Patrice E. Poubelle ◽  
...  
Keyword(s):  
Interleukin 1Β ◽  
Monocyte Chemoattractant Protein 1 ◽  
Endometrial Cells ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

scholarly journals Induction of Monocyte Chemoattractant Protein-1 Expression by Angiotensin II in the Pancreatic Islets and β-Cells

Endocrinology ◽  
2007 ◽  
Vol 148 (5) ◽  
pp. 2198-2208 ◽  
Author(s):  
Galina Chipitsyna ◽  
Qiaoke Gong ◽  
Chance F. Gray ◽  
Yasir Haroon ◽  
Erdinc Kamer ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Receptor Antagonist ◽  
Pancreatic Islets ◽  
Converting Enzyme ◽  
Β Cells ◽  
Β Cell ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Angiotensin II (AngII), the principal hormone of the renin-angiotensin system, is actively generated in the pancreas and has been suggested as a key mediator of inflammation. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays an important role in the recruitment of mononuclear cells into the pancreatic islets. In this study, we investigated the potential molecular basis for the role of AngII in islet inflammation through studying its effect on MCP-1. AngII significantly increased the expression of MCP-1 mRNA and protein in the RINm5F β-cell line and activated MCP-1 promoter. AngII-MCP-1 mRNA induction was inhibited by an AngII type 1 receptor antagonist but was unchanged by an AngII type 2 receptor antagonist. AngII-MCP-1 induction was inhibited by the tyrosine kinase inhibitor genistein, suggesting a MAPK signaling mechanism. AngII activated the phosphorylation of ERK1/2 but not p38 or c-Jun NH2-terminal MAPKs. Inhibition of ERK1/2 activation reduced the AngII-induced MCP-1 synthesis. In nonobese diabetic mice pancreata, the temporal pattern of angiotensin-converting enzyme expression correlated well with progression of insulitis and β-cell destruction. Immunostaining of pancreatic serial sections show colocalization of angiotensin-converting enzyme with MCP-1 in β-cells in the islets. In freshly isolated islets from normoglycemic mice, AngII alone and in combination with IL-1β elicited an inflammatory response by stimulation of MCP-1. Our data suggest a positive autocrine/paracrine action for the local pancreatic AngII-generating system during insulitis and provide the first insight into an AngII-initiated signal transduction pathway that regulates MCP-1 as a possible inflammatory mechanism in the islets.

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