scholarly journals Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus

Diabetologia ◽  
2000 ◽  
Vol 43 (6) ◽  
pp. 750-762 ◽  
Author(s):  
D. Ou ◽  
L. A. Mitchell ◽  
D. L. Metzger ◽  
S. Gillam ◽  
A. J. Tingle
Keyword(s):  
Diabetes Mellitus ◽  
T Cells ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Rubella Virus ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Acid Decarboxylase ◽  
Type I ◽  
Glutamic Acid Decarboxylase 65

scholarly journals Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells

2004 ◽  
Vol 101 (39) ◽  
pp. 14204-14209 ◽  
Author(s):  
S.-K. Kim ◽  
K. V. Tarbell ◽  
M. Sanna ◽  
M. Vadeboncoeur ◽  
T. Warganich ◽  
...  
Keyword(s):  
T Cells ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Type I Diabetes ◽  
Acid Decarboxylase ◽  
Type I ◽  
Glutamic Acid Decarboxylase 65

scholarly journals AUTOANTIBODIES TO GLUTAMIC ACID DECARBOXYLASE AS A PATHOGENETIC MARKER OF TYPE I DIABETES MELLITUS

2014 ◽  
Vol 13 (2-3) ◽  
pp. 257
Author(s):  
N. V. Piven ◽  
L. N. Lukhverchyk ◽  
A. I. Burakovsky ◽  
N. V. Polegenkaya ◽  
M. V. Karpovich
Keyword(s):  
Diabetes Mellitus ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Acid Decarboxylase ◽  
Type I

scholarly journals Vitamin B12 Deficiency in type I Diabetes

2020 ◽  
Vol 1 (2) ◽  
pp. 44-49
Author(s):  
Sana Ashiq ◽  
Shabana
Keyword(s):  
Diabetes Mellitus ◽  
Glutamic Acid ◽  
Vitamin B12 ◽  
Glutamic Acid Decarboxylase ◽  
Type I Diabetes ◽  
Vitamin B12 Deficiency ◽  
Autoimmune Gastritis ◽  
Acid Decarboxylase ◽  
Type I ◽  
B12 Deficiency

Diabetes mellitus is a group of metabolic anomalies due to defect in insulin secretion/action. In type I diabetes, there is complete absence of insulin due to destruction of pancreatic beta cells, whereas type 2 diabetes usually involves insulin resistance. A complex interaction between various environmental, genetic and immunological factors leads to development of diabetes. One major problem for treating T1DM is its difficult prognosis because it leads to many complications, including autoimmune gastritis and celiac diseases. In autoimmune gastritis auto/parietal cell antibodies are formed against the intrinsic factor leading to thegastric atrophy. While in celiac disease, intestinal villi atrophy occurs. Both these conditions have a common clinical outcome which is pernicious anemia. The patients suffering from type I diabetes have approximately threefold increased risk for developing vitamin B12 deficiency as compared to the general population. The major genetic risk factor responsible for this disease is any functional change in HLA class II alleles (HLA DQ, DR and DP). These genes are present on chromosome 6 and are involved in approximately 40% cases of  type I diabetes mellitus. The production of glutamic acid decarboxylase and anti-thyroid peroxidase antibodies have also been reported to be associated with this genotype. The glutamic acid decarboxylase converts glutamic acid to gamma-amino butyric acid producing hydrochloric acid from gastric parietal cells. The antibodies against this antigen can cause achlorhydria that can ultimately lead to vitamin B12 deficiency. Hematologic and neurological disorders, as well as a variety of cardiovascular diseases, are the most commonclinical manifestations of deficiency of vitamin B12.

Increased Circulating Ia-Antigen-Bearing T Cells in Type I Diabetes Mellitus

1982 ◽  
Vol 306 (13) ◽  
pp. 785-788 ◽  
Author(s):  
Richard A. Jackson ◽  
Mary A. Morris ◽  
Barton F. Haynes ◽  
George S. Eisenbarth
Keyword(s):  
Diabetes Mellitus ◽  
T Cells ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Ia Antigen
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