scholarly journals Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction in adult offspring

Diabetologia ◽  
1999 ◽  
Vol 42 (1) ◽  
pp. 81-89 ◽  
Author(s):  
K. Holemans ◽  
R. T. Gerber ◽  
K. Meurrens ◽  
F. De Clerck ◽  
L. Poston ◽  
...  
Keyword(s):  
Streptozotocin Diabetes ◽  
Adult Offspring ◽  
Cardiovascular Dysfunction ◽  
Pregnant Rat

scholarly journals Noninvasive Biomarkers for Cardiovascular Dysfunction Programmed in Male Offspring of Adverse Pregnancy

Hypertension ◽  
2021 ◽  
Author(s):  
Rama Lakshman ◽  
Ana-Mishel Spiroski ◽  
Lauren B. McIver ◽  
Michael P. Murphy ◽  
Dino A. Giussani
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Blood Pressure Variability ◽  
Low Frequency ◽  
Human Condition ◽  
Adult Offspring ◽  
Cardiovascular Dysfunction ◽  
Noninvasive Biomarkers

Work in preclinical animal models has established that pregnancy complicated by chronic fetal hypoxia and oxidative stress programmes cardiovascular dysfunction in adult offspring. Translating this to the human condition comes with challenges, including the early diagnosis of affected individuals to improve clinical outcomes. We hypothesize that components of programmed cardiovascular dysfunction in offspring can be identified in vivo via analysis of blood pressure variability and heart rate variability and that maternal treatment with the mitochondria-targeted antioxidant MitoQ is protective. Pregnant rats were exposed to normoxia or hypoxia (13% O 2 ) ±MitoQ (500 μM in water), from 6 to 20 days gestation. Offspring were maintained in normoxia postnatally. At 16 weeks of age, 1 male per litter was instrumented with vascular catheters and a femoral blood flow probe under isoflurane anesthesia. After recovery, arterial blood pressure and femoral flow were recorded in conscious, free-moving rats and analyzed. Offspring of hypoxic pregnancy had (1) increased very-low-frequency blood pressure variability (A) and heart rate variability (B), indices consistent with impaired endothelial function and (2) increased heart rate variability low/high-frequency ratio (C) and low-frequency blood pressure variability (D), indices of cardiac and vascular sympathetic hyperreactivity, respectively. MitoQ ameliorated A and B but not C and D. We show that asymptomatic cardiovascular dysfunction in adult offspring programmed by hypoxic pregnancy can be diagnosed in vivo by blood pressure variability and heart rate variability, suggesting that these noninvasive biomarkers could be translated to the clinical setting. MitoQ protected against programmed endothelial dysfunction but not sympathetic hyperreactivity, highlighting the divergent programming mechanisms involved.

scholarly journals Maternal taurine supplementation in the late pregnant rat stimulates postnatal growth and induces obesity and insulin resistance in adult offspring

2007 ◽  
Vol 579 (3) ◽  
pp. 823-833 ◽  
Author(s):  
Karin Hultman ◽  
Camilla Alexanderson ◽  
Louise Mannerås ◽  
Mats Sandberg ◽  
Agneta Holmäng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Postnatal Growth ◽  
Adult Offspring ◽  
Taurine Supplementation ◽  
Pregnant Rat

scholarly journals Maternal Semistarvation and Streptozotocin-Diabetes in Rats Have Different Effects on the In Vivo Glucose Uptake by Peripheral Tissues in Their Female Adult Offspring

1997 ◽  
Vol 127 (7) ◽  
pp. 1371-1376 ◽  
Author(s):  
Kathleen Holemans ◽  
Rita Van Bree ◽  
Johan Verhaeghe ◽  
Kris Meurrens ◽  
F. André Van Assche
Keyword(s):  
Glucose Uptake ◽  
Streptozotocin Diabetes ◽  
Adult Offspring ◽  
Female Adult ◽  
Peripheral Tissues

scholarly journals 51 MATERNAL SATURATED FAT INTAKE IN PREGNANT RATS PROGRAMMES RENAL AND CARDIOVASCULAR DYSFUNCTION IN HER ADULT OFFSPRING

2012 ◽  
Vol 30 ◽  
pp. e16
Author(s):  
Sarah L. Henry ◽  
Ryan J. Wood-Bradley ◽  
Roger G. Evans ◽  
Luise A. Cullen-McEwen ◽  
John F. Bertram ◽  
...  
Keyword(s):  
Saturated Fat ◽  
Adult Offspring ◽  
Fat Intake ◽  
Cardiovascular Dysfunction ◽  
Pregnant Rats ◽  
Saturated Fat Intake
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