scholarly journals Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: Insulin secretion in response to physiological concentrations of glucose

Diabetologia ◽  
1998 ◽  
Vol 41 (12) ◽  
pp. 1492-1501 ◽  
Author(s):  
S. Motoyoshi ◽  
T. Shirotani ◽  
E. Araki ◽  
K. Sakai ◽  
K. Kaneko ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pituitary Adenoma ◽  
Cell Line ◽  
Glucose Transporter ◽  
Adenoma Cell ◽  
Att20 Cell

scholarly journals Establishment and Characterization of a Functionally Competent Type 2 Conventional Dendritic Cell Line

2018 ◽  
Vol 9 ◽  
Author(s):  
Matteo Pigni ◽  
Devika Ashok ◽  
Mathias Stevanin ◽  
Hans Acha-Orbea
Keyword(s):  
Dendritic Cell ◽  
Cell Line

A human pituitary adenoma cell line proliferates and maintains some differentiated functions following expression of SV40 large T-antigen

1998 ◽  
Vol 9 (2) ◽  
pp. 169-184 ◽  
Author(s):  
Long Jin ◽  
Elzbieta Kulig ◽  
Xiang Qian ◽  
Bernd W. Scheithauer ◽  
Norman L. Eberhardt ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Line ◽  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Adenoma Cell

scholarly journals Characterization of Insulin Secretion and Resistance in Type 2 Diabetes of Adolescents

2006 ◽  
Vol 91 (2) ◽  
pp. 401-404 ◽  
Author(s):  
Céline Druet ◽  
Nadia Tubiana-Rufi ◽  
Didier Chevenne ◽  
Odile Rigal ◽  
Michel Polak ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion

Characterization of a sialic-acid-rich mucus glycoprotein secreted by a premalignant human colorectal adenoma cell line

1990 ◽  
Vol 46 (6) ◽  
pp. 1059-1065 ◽  
Author(s):  
Anthony P. Corfield ◽  
John R. Clamp ◽  
Angela D. Casey ◽  
Christos Paraskeva
Keyword(s):  
Sialic Acid ◽  
Cell Line ◽  
Colorectal Adenoma ◽  
Adenoma Cell ◽  
Mucus Glycoprotein

RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice

2014 ◽  
Vol 307 (3) ◽  
pp. G330-G337 ◽  
Author(s):  
Ramona Pais ◽  
Tamara Zietek ◽  
Hans Hauner ◽  
Hannelore Daniel ◽  
Thomas Skurk
Keyword(s):  
Insulin Secretion ◽  
Glucose Transporter ◽  
Cell Loss ◽  
Oral Glucose ◽  
Diabetes Therapy ◽  
Incretin Hormone ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingestion. It enhances insulin secretion from pancreatic β-cells and protects from β-cell loss but also promotes satiety and weight loss. In search of chemokines that may reduce GLP-1 secretion we identified RANTES and show that it reduces glucose-stimulated GLP-1 secretion in the human enteroendocrine cell line NCI-H716, blocked by the antagonist Met-RANTES, and in vivo in mice. RANTES exposure to mouse intestinal tissues lowers transport function of the intestinal glucose transporter SGLT1, and administration in mice reduces plasma GLP-1 and GLP-2 levels after an oral glucose load and thereby impairs insulin secretion. These data show that RANTES is involved in altered secretion of glucagon-like peptide hormones most probably acting through SGLT1, and our study identifies the RANTES-receptor CCR1 as a potential target in diabetes therapy.

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