scholarly journals Role of syntaxin in mouse pancreatic beta cells

Diabetologia ◽  
1995 ◽  
Vol 38 (7) ◽  
pp. 860-863 ◽  
Author(s):  
F. Martín ◽  
F. Moya ◽  
L. M. Gutierrez ◽  
J. A. Reig ◽  
B. Soria
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells

scholarly journals Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 104
Author(s):  
Elisa Fernández-Millán ◽  
Carlos Guillén
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Cell Biology ◽  
Pancreatic Beta Cells ◽  
Metabolic Diseases ◽  
Cell Function ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Short Chain Fatty Acids

Type 2 diabetes (T2D) results from impaired beta-cell function and insufficient beta-cell mass compensation in the setting of insulin resistance. Current therapeutic strategies focus their efforts on promoting the maintenance of functional beta-cell mass to ensure appropriate glycemic control. Thus, understanding how beta-cells communicate with metabolic and non-metabolic tissues provides a novel area for investigation and implicates the importance of inter-organ communication in the pathology of metabolic diseases such as T2D. In this review, we provide an overview of secreted factors from diverse organs and tissues that have been shown to impact beta-cell biology. Specifically, we discuss experimental and clinical evidence in support for a role of gut to beta-cell crosstalk, paying particular attention to bacteria-derived factors including short-chain fatty acids, lipopolysaccharide, and factors contained within extracellular vesicles that influence the function and/or the survival of beta cells under normal or diabetogenic conditions.

scholarly journals Role of VEGF-A in Pancreatic Beta Cells

2010 ◽  
Vol 57 (3) ◽  
pp. 185-191 ◽  
Author(s):  
Hirotaka WATADA
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells

scholarly journals Expression of thyrotropin-releasing hormone receptor in immortalized beta-cell lines and rat pancreas

2004 ◽  
Vol 181 (3) ◽  
pp. 401-412 ◽  
Author(s):  
LG Luo ◽  
N Yano
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Cell Lines ◽  
Pancreatic Beta Cells ◽  
Egf Receptor ◽  
Thyrotropin Releasing Hormone ◽  
Receptor Expression ◽  
Receptor Type ◽  
Trh Receptor

Thyrotropin-releasing hormone (TRH), a hypothalamic tripeptide, is expressed in pancreatic islets at peak levels during the late gestation and early neonate period. TRH increases insulin production in cultured beta-cells, suggesting that it might play a role in regulating pancreatic beta-cell function. However, there is limited information on TRH receptor expression in the pancreas. The aim of the present study was to explore the distribution of the TRH receptor in the pancreas and its function in pancreatic beta-cells. TRH receptor type 1 (TRHR1) gene expression was detected by RT-PCR and verified by Northern blotting and immunoblotting in the beta-cell lines, INS-1 and betaTC-6, and the rat pancreatic organ. The absence of TRH receptor type 2 expression in the tissue and cells indicated the tissue specificity of TRH receptor expression in the pancreas. The TRHR1 signals (detected by in situ hybridization) were distributed not only in islets but also in the surrounding areas of the pancreatic ductal and vasal epithelia. The apparent dissociation constant value for the affinity of [(3)H]3-methyl-histidine TRH (MeTRH) is 4.19 in INS-1 and 3.09 nM in betaTC-6. In addition, TRH induced epidermal growth factor (EGF) receptor phosphorylation with a half-maximum concentration of approximately 50 nM, whereas the high affinity analogue of TRH, MeTRH, was 1 nM. This suggested that the affinity of TRH ligands for the TRH receptor influences the activation of EGF receptor phosphorylation in betaTC-6 cells. Our observations suggested that the biological role of TRH in pancreatic beta-cells is via the activation of TRHR1. Further research is required to identify the role of TRHR1 in the pancreas aside from the islets.

Role of Extracellular vesicles in the crosstalk between adipocytes and pancreatic beta-cells

2017 ◽  
Author(s):  
Iacopo Gesmundo ◽  
Eleonora Gargantini ◽  
Enrica Favaro ◽  
Lorenzo Piemonti ◽  
Giovanni Camussi ◽  
...  
Keyword(s):  
Beta Cells ◽  
Extracellular Vesicles ◽  
Pancreatic Beta Cells

Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade

2017 ◽  
Vol 44 ◽  
pp. 11-21 ◽  
Author(s):  
Dornadula Sireesh ◽  
Munuswamy-Ramanujam Ganesh ◽  
Umapathy Dhamodharan ◽  
Murugesan Sakthivadivel ◽  
Srinivasan Sivasubramanian ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Signaling Cascade ◽  
Immune Mediated
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