scholarly journals Sulphatide in islets of Langerhans and in organs affected in diabetic late complications: a study in human and animal tissue

Diabetologia ◽  
1994 ◽  
Vol 37 (10) ◽  
pp. 1000-1006 ◽  
Author(s):  
K. Buschard ◽  
K. Josefsen ◽  
S. V. Hansen ◽  
T. Horn ◽  
M. O. Marshall ◽  
...  
Keyword(s):  
Islets Of Langerhans ◽  
Late Complications ◽  
Animal Tissue ◽  
Diabetic Late Complications

scholarly journals Sulphatide in islets of Langerhans and in organs affected in diabetic late complications: a study in human and animal tissue

Diabetologia ◽  
1994 ◽  
Vol 37 (10) ◽  
pp. 1000-1006 ◽  
Author(s):  
K. Buschard ◽  
K. Josefsen ◽  
S. V. Hansen ◽  
T. Horn ◽  
M. O. Marshall ◽  
...  
Keyword(s):  
Islets Of Langerhans ◽  
Late Complications ◽  
Animal Tissue ◽  
Diabetic Late Complications

Liver: A Target of Late Diabetic Complications

2012 ◽  
Vol 120 (04) ◽  
pp. 202-204 ◽  
Author(s):  
S. Herzig
Keyword(s):  
Hepatic Dysfunction ◽  
Vascular Complications ◽  
Transcriptional Regulators ◽  
Causative Factor ◽  
Late Complications ◽  
The Metabolic Syndrome ◽  
Recent Developments ◽  
Diabetic Late Complications

AbstractWhereas many studies have implicated metabolic liver dysfunction as a causative factor for obesity-related type 2 diabetes and the Metabolic Syndrome, its role as a long-term complication of diabetic metabolism is still mostly unexplored.In contrast to the well-described late diabetic micro- and macro-vascular complications in response to hyperglycemic conditions such as nephro- and retinopathy as well as atherosclerosis, only recent studies have highlighted disturbances of liver function as a novel aspect of diabetic late complications that may substantially impact the overall disease outcome and determine mortality rates in diabetic subjects. Here we will discuss recent developments in this area, particularly focusing on transcriptional regulators of hepatic dysfunction as a long-term consequence of established diabetes.

Diabetes-Associated Biobanking: More Topical Than Ever?

2017 ◽  
Vol 125 (09) ◽  
pp. 603-609 ◽  
Author(s):  
Katharina Lydia Kynast ◽  
Nadine Volk ◽  
Thomas Fleming ◽  
Esther Herpel
Keyword(s):  
Basic Research ◽  
Late Complications ◽  
Scientific Data ◽  
University Hospital ◽  
Diabetes Research ◽  
Technology Platforms ◽  
Physiological Relevance ◽  
Metabolic Imbalance ◽  
Diabetic Late Complications ◽  
The University

AbstractThe increasing prevalence of diabetes and its accompanying long-term complications, as well as the associated economic burden, calls for a rapid clinical translation of biomedical research to better valid the physiological relevance of the findings from basic research. To meet this condition, the Collaborative Research Center (CRC) 1118 has established the first nationwide diabetes-specific Biomaterialbank (BMB) that permanently preserves solid and liquid specimen retro- and prospectively at the Institute of Pathology and Department of Endocrinology of the University Hospital Heidelberg. The main purpose of this BMB is to collect, preserve, characterize and provide human diabetic specimen to researchers investigating the role of reactive metabolites (RM) as cause of diabetic late complications. In this review we discuss the urgent need to support translational and clinical research projects by making use of diabetic solid and liquid specimen and provide an insight into the organization and general conditions of biobanking procedures which are pivotal to guaranteeing high-quality human biomaterial. In light of diabetes-tailored biobanking, we describe our newly initiated activities and introduce the diverse technology platforms that can be used for the investigation of promising molecular targets pertinent for diabetes. With this article we demonstrate that the preservation of rare specimen is also particularly relevant in the non-neoplastic field and contributes to basic investigation, promotes comprehensive scientific data and fortifies the sustainability for diabetes research. In addition, the increased understanding of how metabolic imbalance triggers diabetes onset and progression and favors diabetic late symptoms might hold some promise for future innovative diagnostic and/ or therapeutic applications, eventually adding to the improvement of patient care.

scholarly journals Care and education in patients with diabetic late complications

Diabetologia ◽  
1988 ◽  
Vol 31 (10) ◽  
pp. 776-777
Author(s):  
I. M�hlhauser ◽  
V. J�rgens ◽  
M. Berger
Keyword(s):  
Late Complications ◽  
Diabetic Late Complications
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