Association of the C–509→T polymorphism, alone or in combination with the T869→C polymorphism, of the transforming growth factor-β1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women

2001 ◽  
Vol 79 (2-3) ◽  
pp. 149-156 ◽  
Author(s):  
Yoshiji Yamada ◽  
Akimitsu Miyauchi ◽  
Yasuyuki Takagi ◽  
Masashi Tanaka ◽  
Masashi Mizuno ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Genetic Susceptibility ◽  
Bone Mineral ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Japanese Women ◽  
Mineral Density

scholarly journals Effects of infliximab on markers of inflammation and bone turnover and associations with bone mineral density in patients with ankylosing spondylitis

2008 ◽  
Vol 68 (2) ◽  
pp. 175-182 ◽  
Author(s):  
S Visvanathan ◽  
D van der Heijde ◽  
A Deodhar ◽  
C Wagner ◽  
D G Baker ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Growth Factor ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Transforming Growth Factor ◽  
Type I ◽  
Mineral Density ◽  
High Baseline ◽  
Markers Of Inflammation

Objectives:To evaluate the relationship between bone mineral density (BMD) and biomarkers of bone turnover and inflammation in patients with ankylosing spondylitis (AS) treated with infliximab.Methods:Patients (n = 279) were randomly assigned (3:8) to receive placebo or 5 mg/kg infliximab every 6 weeks through week 96. At week 24, placebo-treated patients crossed over to infliximab 5 mg/kg. Starting at week 36, patients treated with infliximab received dose escalations to 7.5 mg/kg. Hip and spine BMD were measured (baseline, week 24, week 102) using dual-energy x-ray absorptiometry. Sera were analysed (baseline, week 24, week 102) for levels of bone alkaline phosphatase (BAP), osteocalcin, C-terminal cross-linking telopeptide of type I collagen (CTX), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and transforming growth factor-β.Results:Patients treated with infliximab showed significantly greater median increases in BMD of the spine (2.5%, p<0.001) and hip (0.5%, p = 0.033) at week 24 than those who received placebo (0.5% and 0.2% respectively). Baseline levels of IL-6, VEGF, osteocalcin, BAP and CTX were significantly correlated with increases in spinal BMD at weeks 24 and 102 in the infliximab group. In a multiple regression analysis, high baseline osteocalcin levels and early increases in BAP at week 2 were significantly associated with increases in BMD scores of the spine (week 102) and hip (weeks 24 and 102) in the infliximab group.Conclusions:Patients with AS who received infliximab showed significant increases in BMD scores over 2 years. While many significant correlations were observed between BMD scores of the hip and spine and biomarker levels, high baseline osteocalcin levels and early increases in BAP were consistently associated with increases in BMD scores.

Transforming growth factor beta-1 gene polymorphism and bone mineral density in japanese adolescents

1999 ◽  
Vol 106 (4) ◽  
pp. 477-479 ◽  
Author(s):  
Yoshiji Yamada ◽  
Takayuki Hosoi ◽  
Fukashi Makimoto ◽  
Hiroyuki Tanaka ◽  
Yoshiki Seino ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Gene Polymorphism ◽  
Bone Mineral ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mineral Density ◽  
Japanese Adolescents ◽  
Growth Factor Beta
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