Mechanisms of mechanical load-induced atrial natriuretic peptide secretion: role of endothelin, nitric oxide, and angiotensin II

1997 ◽  
Vol 75 (11-12) ◽  
pp. 876-885 ◽  
Author(s):  
Heikki Ruskoaho ◽  
Hanna Leskinen ◽  
Jarkko Magga ◽  
Panu Taskinen ◽  
Pentti Mäntymaa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Mechanical Load ◽  
Peptide Secretion ◽  
Atrial Natriuretic

Role of nitric oxide on atrial natriuretic peptide release induced by angiotensin II in superfused rat atrial tissue

2001 ◽  
Vol 98 (3) ◽  
pp. 105-110 ◽  
Author(s):  
Hayet Soualmia ◽  
Christiane Barthélemy ◽  
Joelle Eurin ◽  
Françoise Masson ◽  
Alain Carayon
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Atrial Tissue ◽  
Peptide Release ◽  
Atrial Natriuretic

Role of NPR-C natriuretic receptor in nitric oxide system activation induced by atrial natriuretic peptide

2006 ◽  
Vol 135 (1-2) ◽  
pp. 63-68 ◽  
Author(s):  
María Ángeles Costa ◽  
Rosana Elesgaray ◽  
Ana María Balaszczuk ◽  
Cristina Arranz
Keyword(s):  
Nitric Oxide ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Oxide System ◽  
System Activation ◽  
Nitric Oxide System ◽  
Atrial Natriuretic

scholarly journals Chronic Endothelium-Dependent Regulation of Arterial Blood Pressure by Atrial Natriuretic Peptide: Role of Nitric Oxide and Endothelin-1

Endocrinology ◽  
2009 ◽  
Vol 150 (5) ◽  
pp. 2382-2387 ◽  
Author(s):  
Karim Sabrane ◽  
Markus-N. Kruse ◽  
Alexandra Gazinski ◽  
Michaela Kuhn
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Methyl Ester ◽  
Atrial Natriuretic Peptide ◽  
Arterial Blood Pressure ◽  
Natriuretic Peptide ◽  
Endothelin 1 ◽  
Arterial Blood ◽  
Atrial Natriuretic

Atrial natriuretic peptide (ANP), via its guanylyl cyclase (GC)-A receptor, plays a key role in the regulation of arterial blood pressure (ABP) and volume. Endothelial-restricted deletion of GC-A in mice [endothelial cell (EC) GC-A knockout (KO)] resulted in hypervolemic hypertension, demonstrating that the endothelium participates in the hypotensive and hypovolemic actions of ANP. Published studies showed that ANP modulates the release of the vasoactive factors nitric oxide (NO) and endothelin-1 (ET-1) from cultured endothelia. Based on these observations, we examined the role of these endothelial factors in ANP-dependent vasodilatation (studied in isolated arteries) and chronic regulation of ABP (measured in awake mice by tail-cuff plethysmography). ANP induced concentration-dependent vasorelaxations of aortic, carotid, and pulmonary arteries. These responses were not different between control and EC GC-A KO mice, and were significantly enhanced after inhibition of NO synthase [by N(G)-nitro-l-arginine-methyl ester]. Intravenous administration of N(G)-nitro-l-arginine-methyl ester to conscious mice significantly increased ABP. The extent of these hypertensive reactions was similar in EC GC-A KO mice and control littermates (increases in systolic blood pressure by ∼25 mm Hg). Conversely, antagonism of ET-1/endothelin-A receptors with BQ-123 reduced ABP significantly and comparably in both genotypes (by ∼11 mm Hg). Finally, the vascular and tissue expression levels of components of the NO system and of immunoreactive ET-1 were not different in control and EC GC-A KO mice. We conclude that the endothelium, but not modulation of endothelial NO or ET-1, participates in the chronic regulation of ABP by ANP.

Role of angiotensin II AT 1 and AT 2 subtype receptors in the regulation of atrial natriuretic peptide expression in salt-restricted rats

2000 ◽  
Vol 95 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Bruna Gigante ◽  
Ornella Piras ◽  
Carmine Savoia ◽  
Paola De Paolis ◽  
Speranza Rubattu ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Peptide Expression ◽  
Atrial Natriuretic

The role of carbon monoxide and nitric oxide in hyperosmolality-induced atrial natriuretic peptide release by hypothalamus in vitro

2004 ◽  
Vol 1016 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Dayane Aparecida Gomes ◽  
Wagner Luiz Reis ◽  
Renato Rizo Ventura ◽  
Alexandre Giusti-Paiva ◽  
Lucila Leico Kagohara Elias ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Peptide Release ◽  
Atrial Natriuretic

Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats

2007 ◽  
Vol 92 (5) ◽  
pp. 903-911 ◽  
Author(s):  
Wagner Luis Reis ◽  
Alexandre Giusti-Paiva ◽  
Renato Rizo Ventura ◽  
Lisandra Oliveira Margatho ◽  
Dayane Aparecida Gomes ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Conscious Rats ◽  
Peptide Release ◽  
Atrial Natriuretic

Role of Angiotensin II in the Renal Response to Atrial Natriuretic Peptide in Normal Subjects

1989 ◽  
Vol 13 ◽  
pp. S55-S58 ◽  
Author(s):  
Hiromi Rakugi ◽  
Toshio Ogihara ◽  
Mitsuaki Nakamaru ◽  
Hiroshi Saito ◽  
Junko Shima ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Normal Subjects ◽  
Renal Response ◽  
Atrial Natriuretic
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