Grenzen inhalativer Vasodilatatoren (Limitations of inhaled vasodilators)

1996 ◽  
Vol 45 (11) ◽  
pp. 1097-1107 ◽  
Author(s):  
M. Booke ◽  
F. Hinder ◽  
J. Meyer
Keyword(s):  
Inhaled Vasodilators

scholarly journals 286: EVALUATION OF INHALED VASODILATORS IN ACUTE RESPIRATORY DISTRESS SYNDROME DUE TO COVID-19

2021 ◽  
Vol 50 (1) ◽  
pp. 129-129
Author(s):  
Rachel Tendler ◽  
Nicholas Barker ◽  
Colin Swenson ◽  
William Bender ◽  
Michael Baker
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Inhaled Vasodilators

Do inhaled vasodilators in ARDS make a difference?

2020 ◽  
pp. 137-141.e1
Author(s):  
Francois Lamontagne ◽  
Paige Guyatt ◽  
Maureen O. Meade
Keyword(s):  
Inhaled Vasodilators

scholarly journals Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome

2021 ◽  
Vol 30 (161) ◽  
pp. 210059
Author(s):  
Mareike Gierhardt ◽  
Oleg Pak ◽  
Dieter Walmrath ◽  
Werner Seeger ◽  
Friedrich Grimminger ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Diffuse Alveolar Damage ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Lung Protective Ventilation ◽  
Specific Patient ◽  
Pulmonary Vasoconstriction ◽  
Inhaled Vasodilators

Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or local pulmonary inflammation, such as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ARDS is characterised by diffuse alveolar damage that leads to protein-rich pulmonary oedema, local alveolar hypoventilation and atelectasis. Inadequate perfusion of these areas is the main cause of hypoxaemia in ARDS. High perfusion in relation to ventilation (V/Q<1) and shunting (V/Q=0) is not only caused by impaired hypoxic pulmonary vasoconstriction but also redistribution of perfusion from obstructed lung vessels. Rebalancing the pulmonary vascular tone is a therapeutic challenge. Previous clinical trials on inhaled vasodilators (nitric oxide and prostacyclin) to enhance perfusion to high V/Q areas showed beneficial effects on hypoxaemia but not on mortality. However, specific patient populations with pulmonary hypertension may profit from treatment with inhaled vasodilators. Novel treatment targets to decrease perfusion in low V/Q areas include epoxyeicosatrienoic acids and specific leukotriene receptors. Still, lung protective ventilation and prone positioning are the best available standard of care. This review focuses on disturbed perfusion in ARDS and aims to provide basic scientists and clinicians with an overview of the vascular alterations and mechanisms of V/Q mismatch, current therapeutic strategies, and experimental approaches.

Inhaled Vasodilators in ARDS

2010 ◽  
pp. 131-134
Author(s):  
François Lamontagne ◽  
Maureen O. Meade
Keyword(s):  
Inhaled Vasodilators
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