Uptake and metabolism of [ 14 C]rinderine and [ 14 C]retronecine in leaf-beetles of the genus Platyphora and alkaloid accumulation in the exocrine defensive secretions

Chemoecology ◽  
2003 ◽  
Vol 13 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Jacques M. Pasteels ◽  
Claudine Theuring ◽  
Donald M. Windsor ◽  
Thomas Hartmann
Tetrahedron ◽  
1994 ◽  
Vol 50 (23) ◽  
pp. 6859-6874 ◽  
Author(s):  
Martin Veith ◽  
Michael Lorenz ◽  
Wilhelm Boland ◽  
Helmut Simon ◽  
Konrad Dettner

Chemoecology ◽  
2001 ◽  
Vol 11 (3) ◽  
pp. 113-120 ◽  
Author(s):  
Jacques M. Pasteels ◽  
Arnaud Termonia ◽  
Donald M. Windsor ◽  
Ludger Witte ◽  
Claudine Theuring ◽  
...  

Diabetes ◽  
1993 ◽  
Vol 42 (7) ◽  
pp. 956-965 ◽  
Author(s):  
B. A. Zinker ◽  
D. B. Lacy ◽  
D. Bracy ◽  
J. Jacobs ◽  
D. H. Wasserman

1993 ◽  
Vol 265 (3) ◽  
pp. G547-G554
Author(s):  
C. A. Hinchman ◽  
A. T. Truong ◽  
N. Ballatori

To identify potential mechanisms for hepatic removal of circulating glutathione (GSH) conjugates, uptake and metabolism of S-2,4-dinitrophenylglutathione (DNP-SG) were examined in isolated perfused livers from rat and guinea pig. Guinea pig livers perfused with 5 mumol of DNP-SG in a recirculating system (50 microM initial concn) rapidly cleared the conjugate from the perfusate (half time 3.7 min), whereas clearance was considerably slower in rat liver (half time 35 min). Disappearance of DNP-SG from the perfusate was accompanied by a simultaneous appearance of DNP-SG and its metabolites in bile. Addition of acivicin, an inhibitor of gamma-glutamyltransferase (gamma-GT), to the perfusate resulted in a marked decrease in DNP-SG clearance by guinea pig liver but had no effect in rat liver, suggesting that in the guinea pig this process is largely dependent on sinusoidal gamma-GT activity. However, even in the presence of acivicin, rat and guinea pig livers removed nearly one-half of the administered DNP-SG from the recirculating perfusate over 30 min. High concentrations of DNP-SG were found in bile (up to 3.7 mM), indicating that the liver is capable of transporting the intact conjugate from the circulation. When rat livers were perfused with higher concentrations of DNP-SG (100 and 250 microM), biliary excretion of DNP-SG increased dose dependently, with concentrations in bile reaching 10 mM at the higher dose. This was accompanied by a dose-dependent choleresis.(ABSTRACT TRUNCATED AT 250 WORDS)


2013 ◽  
Vol 100 (3) ◽  
pp. S23
Author(s):  
M. Pavone ◽  
S. Malpani ◽  
M. Dyson ◽  
D. Monsivais ◽  
N. Mittal ◽  
...  

Plants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 489
Author(s):  
Amber Hageman ◽  
Elizabeth Van Volkenburgh

Drought is a major limiter of yield in common bean, decreasing food security for those who rely on it as an important source of protein. While drought can have large impacts on yield by reducing photosynthesis and therefore resources availability, source strength is not a reliable indicator of yield. One reason resource availability does not always translate to yield in common bean is because of a trait inherited from wild ancestors. Wild common bean halts growth and seed filling under drought and awaits better conditions to resume its developmental program. This trait has been carried into domesticated lines, where it can result in strong losses of yield in plants already producing pods and seeds, especially since many domesticated lines were bred to have a determinate growth habit. This limits the plants ability to produce another flush of flowers, even if the first set is aborted. However, some bred lines are able to maintain higher yields under drought through maintaining growth and seed filling rates even under water limitations, unlike their wild predecessors. We believe that maintenance of sink strength underlies this ability, since plants which fill seeds under drought maintain growth of sinks generally, and growth of sinks correlates strongly with yield. Sink strength is determined by a tissue’s ability to acquire resources, which in turn relies on resource uptake and metabolism in that tissue. Lines which achieve higher yields maintain higher resource uptake rates into seeds and overall higher partitioning efficiencies of total biomass to yield. Drought limits metabolism and resource uptake through the signaling molecule abscisic acid (ABA) and its downstream affects. Perhaps lines which maintain higher sink strength and therefore higher yields do so through decreased sensitivity to or production of ABA.


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