The role of growth hormone and insulin-like growth factors in the immune system

1998 ◽  
Vol 54 (10) ◽  
pp. 1083-1094 ◽  
Author(s):  
S. C. van Buul-Offers ◽  
R. Kooijman
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Immune System ◽  
Insulin Like Growth Factors

The Potential Role of Insulin-Like Growth Factors in Skeletal Muscle Regeneration

1996 ◽  
Vol 21 (4) ◽  
pp. 236-250 ◽  
Author(s):  
Jamie MacGregor ◽  
Wade S. Parkhouse
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Growth Factors ◽  
Muscle Regeneration ◽  
Potential Role ◽  
Tissue Growth ◽  
Skeletal Muscle Regeneration ◽  
Tissue Type ◽  
Insulin Like Growth Factors

The role of the insulin-like growth factors I and II (IGF-I and IGF-II), previously known as the somatomedins, in general growth and development of various tissues has been known for many years. Thought of exclusively as endocrine factors produced by the liver, and under the control of growth hormone, the somatomedins were known as the intermediaries by which growth hormone exerted its cellular effects during tissue growth and maturation. Eventually it was discovered that virtually every tissue type is capable of autocrine production of the IGFs, and their involvement in skeletal muscle tissue repair and regeneration became apparent. Recent advances in technology have allowed the characterisation of many of the different growth factors believed to play a role in muscle regeneration, and experimental manipulations of cells in culture have provided insight into the effects of the various growth factors on the myoblast. This paper explores the potential role of the IGFs in skeletal muscle regeneration. A critical role of IGF-II in terminal differentiation of proliferating muscle precurser cells following injury is proposed. Key words: growth factors, myogenesis, skeletal muscle regeneration

The role of growth hormone/insulin-like growth factors in adipocyte differentiation

Metabolism ◽  
1995 ◽  
Vol 44 ◽  
pp. 45-49 ◽  
Author(s):  
Martin Wabitsch ◽  
Hans Hauner ◽  
Eberhard Heinze ◽  
Walter M. Teller
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Adipocyte Differentiation ◽  
Insulin Like Growth Factors

scholarly journals The relationship between the pituitary somatotrophic function and the immune system, its role in the development of neoplasia

2013 ◽  
Vol 59 (1) ◽  
pp. 30-34
Author(s):  
S A Dogadin ◽  
M A Dudina ◽  
A A Savchenko
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Immune System ◽  
Immune Cells ◽  
Functional Activity ◽  
Immune Disorders ◽  
Neoplastic Processes ◽  
The Relationship ◽  
Survivorship Rate

The present review is focused on the relationship between growth hormone (GH) production and the state of the immune system. The influence of growth factors on the population and subpopulation composition of CD-expressing lymphocytes, functional activity of immune cells, and apoptosis is discussed. The detailed description of the role of disturbances in the pituitary somatotrophic function and the concomitant immune disorders is presented with special reference to the development of neoplastic processes. Changes in the immune system of the patients with chronic hypersecretion of growth factors are described. Tight interactions between the immune and endocrine systems appear to greatly contribute to tumour pathogenesis and have direct effect on the survivorship rate among the patients with acromegaly.

The role of growth hormone, insulin-like growth factors (IGFs), and IGF-binding proteins in experimental diabetic kidney disease

Metabolism ◽  
1995 ◽  
Vol 44 ◽  
pp. 67-71 ◽  
Author(s):  
Allan Flyvbjerg ◽  
Daniel Landau ◽  
Horacio Domene ◽  
Lute Hernandez ◽  
Henning Grønbæk ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Binding Proteins ◽  
Igf Binding Proteins ◽  
Diabetic Kidney ◽  
Igf Binding ◽  
Insulin Like Growth Factors
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