Genetic influence on immune responses to an N. brasiliensis infection: Surface expression and occupancy of IgE receptors and histamine releasability of mast cells

1997 ◽  
Vol 46 (0) ◽  
pp. 17-18 ◽  
Author(s):  
X.-J. Chen ◽  
L. Enerbäck
Keyword(s):  
Mast Cells ◽  
Immune Responses ◽  
Surface Expression ◽  
Genetic Influence ◽  
Ige Receptors ◽  
Histamine Releasability

scholarly journals Ubiquitous Overexpression of Chromatin Remodeling Factor SRG3 Exacerbates Atopic Dermatitis in NC/Nga Mice by Enhancing Th2 Immune Responses

2021 ◽  
Vol 22 (4) ◽  
pp. 1553
Author(s):  
Sung Won Lee ◽  
Hyun Jung Park ◽  
Jungmin Jeon ◽  
Yun Hoo Park ◽  
Tae-Cheol Kim ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cells ◽  
Immune Responses ◽  
Chromatin Remodeling ◽  
Skin Diseases ◽  
Immunoglobulin E ◽  
Critical Role ◽  
Interleukin 4 ◽  
Inflammatory Skin Diseases ◽  
Immune Disorder

The SWItch (SWI)3-related gene (SRG3) product, a SWI/Sucrose Non-Fermenting (SNF) chromatin remodeling subunit, plays a critical role in regulating immune responses. We have previously shown that ubiquitous SRG3 overexpression attenuates the progression of Th1/Th17-mediated experimental autoimmune encephalomyelitis. However, it is unclear whether SRG3 overexpression can affect the pathogenesis of inflammatory skin diseases such as atopic dermatitis (AD), a Th2-type immune disorder. Thus, to elucidate the effects of SRG3 overexpression in AD development, we bred NC/Nga (NC) mice with transgenic mice where SRG3 expression is driven by the β-actin promoter (SRG3β-actin mice). We found that SRG3β-actin NC mice exhibit increased AD development (e.g., a higher clinical score, immunoglobulin E (IgE) hyperproduction, and an increased number of infiltrated mast cells and basophils in skin lesions) compared with wild-type NC mice. Moreover, the severity of AD pathogenesis in SRG3β-actin NC mice correlated with expansion of interleukin 4 (IL4)-producing basophils and mast cells, and M2 macrophages. Furthermore, this accelerated AD development is strongly associated with Treg cell suppression. Collectively, our results have identified that modulation of SRG3 function can be applied as one of the options to control AD pathogenesis.

Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses

2011 ◽  
Vol 35 (1) ◽  
pp. 125-134 ◽  
Author(s):  
Sahar Da’as ◽  
Evelyn M. Teh ◽  
J. Tristan Dobson ◽  
Gheyath K. Nasrallah ◽  
Eileen R. McBride ◽  
...  
Keyword(s):  
Mast Cells ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

IgE Receptors from Rat Intestinal Mucosal and Peritoneal Mast Cells Show Mast Cell Subtype-Specific Differences

1989 ◽  
Vol 88 (1-2) ◽  
pp. 200-202
Author(s):  
M. Swieter ◽  
B.M.C. Chan ◽  
T.D.G. Lee ◽  
C.J. Rimmer ◽  
A. Froese ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cell Subtype ◽  
Ige Receptors ◽  
Peritoneal Mast Cells

83. Histamine release from rat mast cells by antibodies against IgE-receptors

1978 ◽  
Vol 61 (3) ◽  
pp. 153 ◽  
Author(s):  
T ISHIZAKA ◽  
K ISHIZAKA ◽  
D CONRAD ◽  
A FROESE
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Ige Receptors ◽  
Rat Mast Cells

scholarly journals Selective Early Production of CCL20, or Macrophage Inflammatory Protein 3α, by Human Mast Cells in Response to Pseudomonas aeruginosa

2003 ◽  
Vol 71 (1) ◽  
pp. 365-373 ◽  
Author(s):  
Tong-Jun Lin ◽  
Lauren H. Maher ◽  
Kaede Gomi ◽  
Jeffrey D. McCurdy ◽  
Rafael Garduno ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Mast Cells ◽  
Immune Responses ◽  
Immunoglobulin E ◽  
Calcium Ionophore ◽  
Human Mast Cell ◽  
Gm Csf ◽  
Human Mast Cells ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

ABSTRACT Mast cells are important as sentinel cells in host defense against bacterial infection. Much of their effectiveness depends upon recruiting other immune cells; however, little is known about the mechanisms of this response. CCL20, also known as macrophage inflammatory protein-3α (MIP-3α), Exodus, and LARC, is a chemokine known to be a potent chemoattractant for immature dendritic cells and T cells. In this study, we examined the human mast cell production of both CCL20 and granulocyte-macrophage colony-stimulating factor (GM-CSF), a critical cytokine for innate immune responses in the lung, in response to Pseudomonas aeruginosa. Reverse transcription-PCR and Western blot analysis demonstrated that the human mast cells (HMC-1) express CCL20 mRNA and are able to produce a significant amount (32.4 ng/ml) of CCL20 protein following stimulation by calcium ionophore and phorbol myristate acetate. Importantly, P. aeruginosa potently stimulated CCL20 production in human cord blood-derived mast cells (CBMC), with production peaking at 6 h after stimulation. This time course of expression was distinct from that of GM-CSF, which peaked after 24 to 48 h. Significant CCL20 production did not occur following immunoglobulin E-mediated activation of CBMC under conditions which induced a substantial GM-CSF response. Interestingly, the CCL20 response of mast cells to P. aeruginosa was relatively resistant to inhibition by the corticosteroid dexamethasone, interleukin-10, or cyclosporine, while GM-CSF production was potently inhibited. However, P. aeruginosa-induced CCL20 production was blocked by the protein kinase C (PKC) inhibitor Ro 31-8220 and a PKC pseudosubstrate. These results support a role for human mast cells in the initiation of immune responses to P. aeruginosa infection.

Sign in / Sign up

Export Citation Format

Share Document