The incorporation of 5-fluorouracil into rat liver tumor and normal tissues after administration by the hepatic artery during temporary portal vein clamping

1990 ◽  
Vol 190 (1) ◽  
pp. 183-192 ◽  
Author(s):  
I. A. El Hag ◽  
B. Jakobsson ◽  
P. -E. Jönsson ◽  
U. Stenram
Keyword(s):  
Portal Vein ◽  
Hepatic Artery ◽  
Rat Liver ◽  
Liver Tumor ◽  
Normal Tissues ◽  
Portal Vein Clamping

Hepatic artery and portal vein vascularization of normal and cirrhotic rat liver

Hepatology ◽  
1994 ◽  
Vol 19 (5) ◽  
pp. 1189-1197 ◽  
Author(s):  
Ibrahim Kassissia ◽  
Antoine Brault ◽  
P.-Michel Huet
Keyword(s):  
Portal Vein ◽  
Hepatic Artery ◽  
Rat Liver

scholarly journals Adult Embryonal Sarcoma of the Liver: Management of a Massive Liver Tumor

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Daniela Treitl ◽  
Alexandra Roudenko ◽  
Siba El Hussein ◽  
Magda Rizer ◽  
Philip Bao
Keyword(s):  
Abdominal Pain ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Liver Tumor ◽  
Pringle Maneuver ◽  
Parenchymal Transection ◽  
Left Hepatectomy ◽  
Early Satiety ◽  
Bland Embolization ◽  
Embryonal Sarcoma

Undifferentiated embryonal sarcomas of the liver are extremely rare cases in adults. We report the case of a 30-year-old male who presented with early satiety and abdominal pain due to a massive tumor originating from the left liver and occupying the entire epigastrium. The patient underwent bland embolization in an attempt to decrease the size of the tumor. He then underwent a formal left hepatectomy with resection of liver segments 2, 3, and 4. Extrahepatic inflow control of the portal vein and hepatic artery was performed prior to parenchymal transection. No Pringle maneuver was required. Pathology analysis showed a 45 cm tumor consistent with an undifferentiated embryonal sarcoma and negative microscopic margins. The epidemiology, treatment, and prognosis of this unusual cancer presentation are reviewed.

Exact Detection of Arterial and Portal Branches of the Terminal Afferent Vessels in the Rat Liver By Means of Corrosion Casts and Edx

1999 ◽  
Vol 5 (S2) ◽  
pp. 1204-1205
Author(s):  
Udo M. Spornitz ◽  
Irena Bartuskova ◽  
Gianni Morson
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Blood Supply ◽  
Rat Liver ◽  
Blood Stream ◽  
Morphological Features ◽  
Corrosion Casts ◽  
Scanning Electron

The physiological necessity of the dual afferent blood supply of the liver and the morphological features of the macrocirculation are well understood. The microcirculation, however, still poses a number of unsolved questions. In particular the nature of the terminal junctions of the arterial and portal blood stream with the sinusoids has so far not been satisfactorily elucidated (1-2). Scanning electron microscopy alone or in combination with corrosion casts cannot solve the problem, because it remains difficult to tell the different vessels apart. Under favorable circumstances the terminal portal vein is the easiest to be distinguished with corrosion casts. This is due to the fact that its relatively wide branches surround the classical liver lobules along the major parts of their circumference. The diameter of the terminal hepatic artery is in its initial segments not as wide as the initial segments of the terminal portal vein.

Selective radioprotection of hepatocytes by systemic and portal vein infusions of amifostine in a rat liver tumor model

2001 ◽  
Vol 50 (2) ◽  
pp. 473-478 ◽  
Author(s):  
Zvi Symon ◽  
Micha Levi ◽  
William D Ensminger ◽  
David E Smith ◽  
Theodore S Lawrence
Keyword(s):  
Portal Vein ◽  
Rat Liver ◽  
Liver Tumor ◽  
Tumor Model

scholarly journals Presinusoidal and proximal intrasinusoidal confluence of hepatic artery and portal vein in rat liver: Functional evidence by orthograde and retrograde bivascular perfusion

Hepatology ◽  
1994 ◽  
Vol 19 (5) ◽  
pp. 1198-1207 ◽  
Author(s):  
Yuji Watanabe ◽  
Gerhard P. Püschel ◽  
Andreas Gardemann ◽  
Kurt Jungermann
Keyword(s):  
Portal Vein ◽  
Hepatic Artery ◽  
Rat Liver

Intrahepatic blood flow distribution in the perfused rat liver: effect of hepatic artery perfusion

1996 ◽  
Vol 271 (4) ◽  
pp. G561-G567 ◽  
Author(s):  
F. J. Burczynski ◽  
B. A. Luxon ◽  
R. A. Weisiger
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Artery ◽  
Rat Liver ◽  
Transit Time ◽  
Flow Distribution ◽  
Low Flow ◽  
Perfused Rat Liver ◽  
Time Dispersion ◽  
Artery Perfusion

Variations in blood flow to different sinusoids within the liver can prevent uniform uptake of solutes from plasma and contribute to cellular ischemia in low-flow states. However, the degree of variability and the role of hepatic artery perfusion in maintaining uniform flow are poorly defined. We used an indicator dilution technique to compare the distribution of sinusoidal transit times in isolated rat livers perfused through the portal vein alone with livers perfused using both portal vein and hepatic artery. Physiological flow rates were used in each case (1.2 +/- 0.3 ml.min-1.g liver-1), but the second group received 32% of flow through the hepatic artery. Intralobular flow heterogeneity was further assessed by gamma counting of small (approximately 100 mg) pieces of the liver after bolus injection of approximately 5 mCi of a highly extracted compound ([125I])triiodothyronine) into the portal vein. Hepatic artery perfusion had no significant effect on mean sinusoidal transit time or intrahepatic distribution volume for 51Cr-labeled red blood cells or 125I-albumin. Analysis of the outflow profiles indicated that hepatic artery perfusion did not affect transit time dispersion. However, heterogeneity of flow to individual portions of the liver, measured as the coefficient of variation, increased from 19 to 30%. These results indicate relatively uniform perfusion of the sinusoids in the portally perfused rat liver and that additional perfusion of the hepatic artery does not further improve hemodynamics. These results have significance for the design and interpretation of transport studies with the use of the perfused rat liver model.

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